2021 - 2024 The elucidation of complicated genetic backgrounds and pathogenicity in patients with inherited primary arrhythmia syndromes caused by unknown etiology
2023 - 2024 持田記念医学薬学振興財団研究助成
2020 - 2023 The genetic analysis and underlying function of the endoplasmic reticulum membrane protein targeting inherited arrhythmogenic syndromes
2020 - 2023 SNTA1変異による早期再分極症候群発症メカニズムの解明に関する研究
2018 - 2020 Research project for SCN5A dominant-negative mechanism
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Papers (53):
Asami Kashiwa, Hideki Itoh, Takeru Makiyama, Yuko Wada, Junichi Ozawa, Koichi Kato, Megumi Fukuyama, Tadashi Nakajima, Seiko Ohno, Minoru Horie. Clinical characterization of type 1 long QT syndrome caused by C-terminus Kv7.1 variants. Heart Rhythm. 2024
Masao Yoshinaga, Yumiko Ninomiya, Yuji Tanaka, Megumi Fukuyama, Koichi Kato, Seiko Ohno, Minoru Horie, Hiromitsu Ogata. Holter Electrocardiographic Approach to Predicting Outcomes of Pediatric Patients With Long QT Syndrome. Circulation journal : official journal of the Japanese Circulation Society. 2023
Yusuke Okuyama, Tomoya Ozawa, Takuma Nishikawa, Yusuke Fujii, Koichi Kato, Yoshihisa Sugimoto, Yoshihisa Nakagawa, Takashi Ashihara. Association with the nonparoxysmal atrial fibrillation duration and outcome of ExTRa Mapping-guided rotor ablation. Journal of arrhythmia. 2023. 39. 4. 531-538
Megumi Fukuyama, Minoru Horie, Koichi Kato, Hisaaki Aoki, Shuhei Fujita, Yoko Yoshida, Hisanori Sakazaki, Takako Toda, Michihiko Ueno, Gaku Izumi, et al. Calmodulinopathy in Japanese Children - Their Cardiac Phenotypes Are Severe and Show Early Onset in Fetal Life and Infancy. Circulation journal : official journal of the Japanese Circulation Society. 2023
Jingshan Gao, Takeru Makiyama, Yuta Yamamoto, Takuya Kobayashi, Hisaaki Aoki, Thomas L Maurissen, Yimin Wuriyanghai, Asami Kashiwa, Tomohiko Imamura, Takanori Aizawa, et al. Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation. Arrhythmia and electrophysiology. 2023. 16. 3. e011387
今村知彦, 牧山武, 小澤淳一, 相澤卓範, 柏麻美, 糀谷泰彦, 加藤浩一, 青木寿明, 鈴木博, 園田桂子, et al. Clinical Aspects of Brugada Syndrome in Children: The Impact of Gender and Age on the Prognosis. 日本循環器学会学術集会(Web). 2022. 86th
今村知彦, 牧山武, 小澤淳一, 相澤卓範, 柏麻美, 山本雄大, 糀谷泰彦, 加藤浩一, 青木寿明, 大野聖子, et al. Clinical Characteristics of Pediatric Brugada Syndrome in Japanese Registry. 日本循環器学会学術集会(Web). 2021. 85th
The dominant-negative effect of Nav 1.5 variants through channel dimerization does not play a crucial role in determining a phenotype severity
(2024)
The dominant-negative effect of Loss of function Nav 1.5 variants is not a critical determinant of phenotype severity
(ESC Congress 2023 2023)
Compound heterozygous SCN5A variants caused severe bradyarrhythmia via complex channel-channel interaction.
(Japanese Circulation Society Annual Meeting 2023)
Correction of cryptic donor site splicing by antisense oligo nucleotides in a case of Brugada syndrome.
(Japanese Circulation Society Annual Meeting 2023)
Correction of SCN5A splicing error of Brugada syndrome patient by antisense oligo nucleotides
(Asia Pacific Heart Rhythm Society 2022 2022)