Rchr
J-GLOBAL ID：201801008710224853
Update date: Nov. 16, 2024
Nakano Masataka
Nakano Masataka
Affiliation and department：
Job title：
Post-Doctoral Research Associate
Research field (1)：
Molecular biology
Research keywords (5)：
クロマチンリモデリング
, RNA修飾
, microRNA
, 転写後調節
, 薬物代謝
Research theme for competitive and other funds (15)：
- 2022 - 2024 A-to-I RNA編集酵素を阻害する抗がんDNAアプタマー開発研究
- 2023 - 2024 In cellular study of newly identified aptamers inhibitors of METTL3-METTL14 complex for cancer
- 2022 - 2023 クロマチンリモデラーを標的とした新規前立腺がん治療
- 2020 - 2023 RNA修飾による薬物代謝酵素発現制御
- 2021 - 2022 Characterization of DNA aptamer inhibiting ADAR1 for novel cancer therapy by using HS-AFM and SICM
- 2020 - 2022 ヒト初代近位尿細管上皮細胞を用いた動態制御因子の誘導及びDIKI評価系の開発
- 2022 - クロマチンリモデリングによる恒常的アンドロスタン受容体機能制御機構の解明
- 2020 - 2021 Elucidation of dynamic structural property of ADAR1 in a process of A-to-I RNA editing for development of ADAR1 inhibitors for cancer therapy
- 2019 - 2021 喫煙に応答する異物代謝・解毒酵素のエピトランスクリプトーム制御の解明
- 2020 - 2021 クロマチンリモデリング因子による核内受容体pregnane X receptor 機能制御
- 2018 - 2020 薬物動態制御因子PXRおよびCARの発現に与えるRNA編集の影響
- 2018 - 2019 Visualization of dynamics of cytochrome P450 in the metabolic process
- 2018 - 2019 microRNAのエピトランスクリプトーム解析によるヒト薬物代謝能変動の解明
- 2016 - 2018 薬物代謝関連遺伝子の発現における転写後調節の役割
- エピトランスクリプトミクスによる薬物動態制御機構の解明
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Papers (47)：
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Soshi Shinohara, Seijo Uchijima, Keiya Hirosawa, Mai Nagaoka, Masataka Nakano, Miki Nakajima, Tatsuki Fukami. Arylacetamide deacetylase regulates hepatic iron homeostasis to protect against carbon tetrachloride-induced ferroptosis. Archives of toxicology. 2024. 98. 12. 4059-4075
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Rei Sato, Tatsuki Fukami, Kazuya Shimomura, Yongjie Zhang, Masataka Nakano, Miki Nakajima. Characterization of human alcohol dehydrogenase 4 and aldehyde dehydrogenase 2 as enzymes involved in the formation of 5-carboxylpirfenidone, a major metabolite of pirfenidone. Drug metabolism and disposition: the biological fate of chemicals. 2024
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Madhu Biyani, Kirti Sharma, Maeda Shoei, Hinako Akashi, Masataka Nakano, Miki Nakajima, Manish Biyani. A novel aptamer-antibody sandwich electrochemical sensor for detecting ADAR1 in complex biological samples. Biosensors and Bioelectronics: X. 2024. 19. 100491-100491
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Shiori Hashiba, Masataka Nakano, Itsuki Yokoseki, Etsushi Takahashi, Masayuki Kondo, Yoichi Jimbo, Naoki Ishiguro, Hiroshi Arakawa, Tatsuki Fukami, Miki Nakajima. Cytochrome P450 and UDP-glucuronosyltransferase expressions, activities, and induction abilities in 3D-cultured human renal proximal tubule epithelial cells. Drug metabolism and disposition: the biological fate of chemicals. 2024. 52. 9. 949-956
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Shimon Nakashima, Tatsuki Fukami, Takashi Kudo, Masataka Nakano, Akiko Matsui, Naoki Ishiguro, Miki Nakajima. Iminium ion metabolites are formed from nintedanib by human CYP3A4. Drug metabolism and pharmacokinetics. 2024. 57. 101025-101025
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MISC (2)：
Lectures and oral presentations (132)：
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シャトルタンパク質NOLC1は核内受容体PXRのリガンド依存的な核移行を促進する
(日本薬学会北陸支部第136回例会 2024)
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ヒト肝におけるシトクロムP450のポリコーム複合体PRC1/2による発現制御
(日本薬学会北陸支部第136回例会 2024)
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Impact of G-quadruplex on carboxylesterase 2-dependent drug and lipid metabolism.
(26th North American ISSX and 39th JSSX Meeting)
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Impact of DNA G-quadruplex formation on CYP3A4 gene transcription.
(26th North American ISSX and 39th JSSX Meeting)
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Mechanism by which AADAC regulates hepatic lipid level in vivo.
(26th North American ISSX and 39th JSSX Meeting)
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Education (3)：
- 2014 - 2017 Kanazawa University Graduate School of Medical Science
- 2012 - 2014 Kanazawa University Graduate School of Medical Science
- 2008 - 2012 Kanazawa University
Professional career (1)：
Work history (3)：
- 2024/11 - 現在 Purdue University Department of Medicinal Chemistry and Molecular Pharmacology Post-Doctoral Research Associate
- 2018/04 - 2024/06 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy
- 2022/04 - 2023/03 Purdue University
Awards (6)：
Association Membership(s) (3)：
日本分子生物学会
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
