Rchr
J-GLOBAL ID：201801008763486493   Update date: Jan. 26, 2025

Ohshima Yasuhiro

オオシマ ヤスヒロ | Ohshima Yasuhiro
Affiliation and department：
National Institutes for Quantum and Radiological Science and Technology

About National Institutes for Quantum and Radiological Science and Technology


Research field  (4)： Pharmaceuticals - health and biochemistry ,  Tumor diagnostics and therapeutics ,  Tumor diagnostics and therapeutics ,  Radiology
Research theme for competitive and other funds  (13)：
  • 2022 - 2025 Establishment of a method for controlling the intensity of radiation cytotoxicity by controlling purine receptor activity
  • 2021 - 2024 New diagnostic and therapeutic strategy for organ fibrosis: Radionuclide ablation of active fibroblasts
  • 2020 - 2024 The new strategy for radioresistance in cancer associated with p53 mutation using targeted alpha therapy
  • 2021 - 2024 Investigation of the function of a deubiquitinase, Otub1 on the targeted alpha-radionuclide therapy
  • 2016 - 2019 がん幹細胞及びがん細胞を標的とするα線放出核種を用いた膵がんの新規治療法開発
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Papers (43)：
  • Hiroyuki Suzuki, Saki Yamashita, Shoko Tanaka, Kento Kannaka, Ichiro Sasaki, Yasuhiro Ohshima, Shigeki Watanabe, Kazuhiro Ooe, Tadashi Watabe, Noriko S. Ishioka, et al. An 211At-labeled alpha-melanocyte stimulating hormone peptide analog for targeted alpha therapy of metastatic melanoma. European Journal of Nuclear Medicine and Molecular Imaging. 2025
  • Shigeki Watanabe, Yuto Kondo, Ichiro Sasaki, Yasuhiro Ohshima, Hiroyuki Kimura, Noriko S. Ishioka. Copper-mediated astatination of 211At-labelled prostate-specific membrane antigen probes in the presence of basic salts. Tetrahedron. 2024. 133920-133920
  • Yasuhiro Ohshima, Ichiro Sasaki, Shigeki Watanabe, Tetsuya Sakashita, Tatsuya Higashi, Noriko S. Ishioka. Organic cation transporter 3 mediates the non-norepinephrine transporter driven uptake of meta-[211At]astato-benzylguanidine. Nuclear Medicine and Biology. 2022. 112-113. 44-51
  • Yuto Kondo, Hiroyuki Kimura, Ichiro Sasaki, Shigeki Watanabe, Yasuhiro Ohshima, Yusuke Yagi, Yasunao Hattori, Manami Koda, Hidekazu Kawashima, Hiroyuki Yasui, et al. Copper-mediated radioiodination and radiobromination via aryl boronic precursor and its application to 125I/77Br-labeled prostate-specific membrane antigen imaging probes. Bioorganic & Medicinal Chemistry. 2022. 69. 116915-116915
  • Ayaka Kanai, Hirofumi Hanaoka, Aiko Yamaguchi, Isa Mahendra, Citra Palangka, Yasuhiro Ohshima, Tetsuya Higuchi, Yoshito Tsushima. Enhancing the accumulation level of 3-[18F]fluoro-L-α-methyltyrosine in tumors by preloading probenecid. Nuclear Medicine and Biology. 2022. 104-105. 47-52
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MISC (9)：
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Patents (1)：
  • 放射性フッ素標識化合物
Lectures and oral presentations  (4)：
  • ドイツヴュルツブルク大学病院核医学講座への留学を終えて
    (令和2年度東京RBC新春放談会 2021)
  • Development of meta-[211At]astatobenzylguanidine -basic study with pheochromocytoma model-
    (2018)
  • α線放出211Atを利用した悪性褐色細胞腫治療薬 メタアスタトベンジルグアニジン(MABG)の開発
    (第13回日本分子イメージング学会 2018)
  • 悪性褐色細胞腫に対するα核種標識meta-[211At]-astato-benzylguanidine (211At-MABG)の開発と基礎的検討
    (第35回臨床画像診断懇話会 2016)
Education (1)：
  • 2007 - 2010 Tokyo University of Science Graduate School of Pharmaceutical Sciences Pharmaceutical Life Sciences (Doctoral course)
Work history (5)：
  • 2020/07 - 現在 National Institutes for Quantum and Radiological Science and Technology
  • 2018/12 - 2020/11 University Hospital Wuerzburg Department of Nuclear Medicine
  • 2016/04 - 2020/06 National Institutes for Quantum and Radiological Science and Technology Quantum Beam Science Research Directorate Senior Researcher
  • 2013/04 - 2016/03 Japan Atomic Energy Agency Quantum Beam Science Directorate Researcher
  • 2010/04 - 2013/03 Japan Atomic Energy Agency Quantum Beam Science Directorate Postdoctoral fellowship
Awards (3)：
  • 2017/07 - 量子科学技術研究開発機構 研究開発功績賞特賞
  • 2012/06 - 第14回放射線プロセスシンポジウム実行委員会 最優秀賞
  • 2010/11 - (一社)日本原子力学会関東・甲越支部 奨励賞
Association Membership(s) (2)：
JAPANESE SOCIETY OF NUCLEAR MEDICINE ,  THE JAPANESE CANCER ASSOCIATION
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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