Sakamoto Akihiko

Affiliation and department：

Research field (3)： Pharmaceuticals - health and biochemistry , Cell biology , Molecular biology

Research keywords (5)：細胞毒性 , 生理機能 , gene expression , acrolein , polyamine

Research theme for competitive and other funds (3)：

2021 - 2024 ヒストン修飾酵素の翻訳調節を介したポリアミンによる遺伝子発現制御機構の解明
2019 - 2021 Identification of translational regulators of histone acetyltransferases
2018 - 2021 TRPA1チャネルを介したアクロレインによる炎症機構の解析

Papers (27)：

Teruyuki Kobayashi, Akihiko Sakamoto, Tamao Hisano, Keiko Kashiwagi, Kazuei Igarashi, Koichi Takao, Takeshi Uemura, Takemitsu Furuchi, Yoshiaki Sugita, Toshiyuki Moriya, et al. Caldomycin, a new guanidopolyamine produced by a novel agmatine homocoupling enzyme involved in homospermidine biosynthesis. Scientific reports. 2024. 14. 1. 7566-7566
Akihiko Sakamoto, Yusuke Terui, Kazuei Igarashi, Keiko Kashiwagi. Transient Receptor Potential Ankyrin 1 (TRPA1) Channel Mediates Acrolein Cytotoxicity in Human Lung Cancer Cells. International journal of molecular sciences. 2023. 24. 14
Teruyuki Kobayashi, Akihiko Sakamoto, Keiko Kashiwagi, Kazuei Igarashi, Koichi Takao, Takeshi Uemura, Toshiyuki Moriya, Tairo Oshima, Yusuke Terui. Putrescine Biosynthesis from Agmatine by Arginase (TtARG) in Thermus thermophilus. Journal of biochemistry. 2023
Takeshi Uemura, Masashi Uchida, Mizuho Nakamura, Momo Shimekake, Akihiko Sakamoto, Yusuke Terui, Kyohei Higashi, Itsuko Ishii, Keiko Kashiwagi, Kazuei Igarashi. A search for acrolein scavengers among food components. Amino Acids. 2023. 55. 4. 509-518
Madoka Yoshida, Takeshi Uemura, Mutsumi Mizoi, Masaaki Waragai, Akihiko Sakamoto, Yusuke Terui, Keiko Kashiwagi, Kazuei Igarashi. Urinary Amino Acid-Conjugated Acrolein and Taurine as New Biomarkers for Detection of Dementia. Journal of Alzheimer's disease : JAD. 2023

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MISC (55)：

坂本明彦, 照井祐介, 植村武史, 植村武史, 五十嵐一衛, 五十嵐一衛, 柏木敬子. Polyamines stimulate the synthesis of circadian clock gene at the level of translation. 日本薬学会年会要旨集(Web). 2021. 141st
植村武史, 植村武史, 中村瑞穂, 中村瑞穂, 坂本明彦, 照井祐介, 柏木敬子, 五十嵐一衛, 五十嵐一衛. Identification of potential preventors for brain stroke from foods. 日本薬学会年会要旨集(Web). 2021. 141st
坂本明彦. Enhancement of the synthesis of histone acetyltransferases by polyamines at the level of translation. 月刊細胞. 2020. 52. 9
岩崎倖千, 坂本明彦, 照井祐介, 五十嵐一衛, 五十嵐一衛, 柏木敬子. Mechanism of polyamine stimulation of Bmal1 synthesis. 日本ポリアミン学会年会プログラム及び抄録集. 2020. 11th
坂本明彦, 照井祐介, 植村武史, 植村武史, 五十嵐一栄, 五十嵐一栄, 柏木敬子. ポリアミンはヒストンアセチル化を促進して遺伝子発現を制御する. 日本生化学会大会(Web). 2020. 93rd

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Lectures and oral presentations (24)：

Molecular mechanisms of cell and tissue toxicity caused by acrolein.
(6th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives. 2022)
Regulation of gene expression through translational stimulation of histone modifying enzymes by polyamines.
(6th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives. 2022)
Polyamines enhance synthesis of the circadian regulator Bmal1 at translational level.
(Gordon Research Conference on Polyamines 2019)
Inhibition of cell growth and viability by excess polyamines through translational repression of specific proteins encoded by members of polyamine modulon in Escherichia coli.
(Gordon Research Conference on Polyamines 2019)
Role of polyamines on cell growth under high temperature environment.
(5th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives. 2018)

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Education (3)：

2011 - 2014 千葉科学大学大学院薬学研究科博士課程
2009 - 2011 千葉科学大学大学院薬学研究科修士課程
2005 - 2009 Chiba Institute of Science Faculty of Pharmacy Department of Pharmacy

Work history (2)：

2024/02 - 2024/04 Hoshi University
2014/04 - 2024/01 Chiba Institute of Science Faculty of Pharmacy Department of Pharmacy

Awards (2)：

Association Membership(s) (4)：

日本ポリアミン学会 , 日本薬学会 , 日本生化学会 , 総合危機管理学会

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