Research field (1)：
Pharmaceuticals - health and biochemistry
Research theme for competitive and other funds (12)：
2021 - 2025 Molecular mechanism underlying organelle trafficking regulated by stractually diverse proton pump vacolar ATPase
2021 - 2024 Ion transport network in oral pathogenic bacteria
2019 - 2022 Common principle of secretory lysosome transport and universal mechanism of organelle trafficking
2018 - 2021 A novel approach to drug development targeting to proton pumping ATPase
2016 - 2018 Exploitation of proton pumping ATPase inhibitors in oral cavity pathogenic bacteria
2015 - 2018 Mechanism for ionic environment formation and organelle trafficking by proton-pumping V-ATPase
2012 - 2014 Mechanism of inhibition of ATP synthase by phytopolyphenols
2013 - 2014 一分子観察によるイソフォーム特異的プロトン輸送ATPase阻害薬の探索
2012 - 2013 ポリフェノール類によるATP合成酵素阻害機構の解明
2009 - 2010 Exploitation of tissue specific proton pump inhibitors
2008 - 2010 Proton Pumping ATPase and Roles of Acidic pH
2006 - 2007 天然資源に含まれる自然免疫制御物質の探索とその制御機構の解析
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Papers (27)：
Takehiro Nishimura, Kosuke Shiga, Mizuki Sekiya, Akihiro Sugawara, Takayuki Yonezawa, Haruhisa Kikuchi. Synthesis of a Library of Terpenoid Alkaloid-like Compounds Containing Medium-sized Rings via Reconstruction of the Humulene Skeleton. Chemistry (Weinheim an der Bergstrasse, Germany). 2024. e202402082
Naomi Matsumoto, Mizuki Sekiya, Ge-Hong Sun-Wada, Yoh Wada, Mayumi Nakanishi-Matsui. The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts. Scientific reports. 2022. 12. 1. 8455-8455
Naomi Matsumoto, Mizuki Sekiya, Yasuyuki Fujimoto, Satoshi Haga, Ge-Hong Sun-Wada, Yoh Wada, Mayumi Nakanishi-Matsui. Functional complementation of V-ATPase a subunit isoforms in osteoclasts. Journal of biochemistry. 2021. 169. 4. 459-466
阪本泰光, 日高興士, 石原司, 中村彰宏, 鈴木義之, 關谷瑞樹, 六本木沙織, 小笠原渉, 田中信忠. Development of inhibitors with a novel mechanism of action targeting S46 DPPs in nonfermenting pathogens. 放射光. 2022. 35. 2. 88-96
