Research field (5)：
Bioorganic chemistry
, Structural/physical organic chemistry
, Pharmaceuticals - chemistry and drug development
, Biochemistry
, Chemical biology
Research keywords (4)：
Bioinorganic chemistry
, imaging
, Iron (Fe) ion
, Chemical Biology
Research theme for competitive and other funds (16)：
2022 - 2026 Chemical-tool-driven research on heme dynamics
2022 - 2024 Development and application of practical ferromics technology
2019 - 2023 Development of novel boron carrier utilizing amino acid transporters specific for glutamine addiction of cancer cells
2020 - 2022 Development of fundamental technology for electron microscopic imaging of short-lived chemical species
2020 - 2022 Development of ferromics probes for molecular and spacial analysis
2018 - 2021 Elucidation and control of iron homeostasis based on iron-sensing technology using N-oxide chemistry
2018 - 2020 細胞骨格を足場とする酸化ストレスナノイメージング法の開発
2017 - 2019 Basic study for chemical biology of heme
2016 - 2019 Development of tumor-selective drug based on synthetic lethal strategy by overcoming oxidative stress tolerance of cancer
2015 - 2017 Development of novel organobismuth molecules as photosensitizers for theranostics of tumor
2013 - 2017 Development of versatile N-oxide-based fluorescent probes to study pathological dysfunction of iron metabolism
2012 - 2015 The study of drug development targeting the stress response in the tumor microenvironment for the treatment of refractory cancer
2011 - 2012 Coordination chemistry to clinical applications-development of MRI probes based on redox chemistry of metal complexes
2010 - 2010 ペプチド型希土類錯体を用いたタンパク質結合性多機能亜鉛蛍光プローブの開発
2008 - 2009 蛍光性希土類錯体を用いた新しいタンパク質認識システムの開発
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Papers (77)：
Aomi Muramatsu, Shinsuke Nakamura, Tasuku Hirayama, Hideko Nagasawa, Akihiro Ohira, Takashi Kitaoka, Hideaki Hara, Masamitsu Shimazawa. Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation. Journal of Pharmacological Sciences. 2024. 155. 2. 44-51
Aomi Muramatsu, Shinsuke Nakamura, Tasuku Hirayama, Hideko Nagasawa, Akihiro Ohira, Takashi Kitaoka, Hideaki Hara, Masamitsu Shimazawa. Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation. Journal of Pharmacological Sciences. 2024. 155. 2. 44-51
Danyang Mi, Izumi Yanatori, Hao Zheng, Yingyi Kong, Tasuku Hirayama, Shinya Toyokuni. Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria. Free radical research. 2024. 1-40
Takumi Kariya, Hayato Hasegawa, Taro Udagawa, Yusaku Inada, Kyoko Nishiyama, Mieko Tsuji, Tasuku Hirayama, Tatsuo Suzutani, Naoki Kato, Shingo Nagano, et al. Elucidation of the stereocontrol mechanisms of the chemical and biosynthetic intramolecular Diels-Alder cycloaddition for the formation of bioactive decalins. RSC advances. 2023. 13. 40. 27828-27838
Mieko Tsuji, Haruno Taira, Taro Udagawa, Tatsuya Aoki, Tasuku Hirayama, Hideko Nagasawa. Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress. Chemical Communications. 2023
2013 - Chemical Society of Japan CSJ Presentation Award 2013
2009 - Japan San Francisco Bay Area Researchers' association Japan San Francisco Bay Area seminar poser award
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Association Membership(s) (7)：
THE JAPANESE CANCER ASSOCIATION
, THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER
, SOCIETY FOR FREE RADICAL RESEARCH JAPAN
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, THE CHEMICAL SOCIETY OF JAPAN
, The Japanese Bioiron Society
, JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
