Akihide Kamiya

カミヤアキヒデ | Akihide Kamiya

Affiliation and department：

Research field (2)： Cell biology , Gastroenterology

Research keywords (3)：発生・分化 , 幹細胞 , 肝臓

Research theme for competitive and other funds (21)：

2022 - 2025 Preparation of a model animal for progressive familial intrahepatic cholestasis using mice with human bile acids
2021 - 2024 Construction of high-throughput drug discovery screening system using bile duct organoids and fluid devices
2021 - 2024 肝星細胞の脱活性化に基づく線維肝の修復機構の解明と再生治療戦略
2020 - 2022 Development of treatment for liver diseases using sex difference of liver functions
2019 - 2022 Fatty acid metabolic system that controls thepathophysiology of steatohepatitis

2017 - 2021 Exosome Therapy for Liver Cirrhosis Using a Novel Regeneration Factor

2016 - 2018 Notch Signaling regulates the development of hepatocelular carcinoma.

2016 - 2018 Establishment of human pluripotent stem cell-derived bile ductal disease analysis system using microfluidic device

2015 - 2018 Analyses of molecular mechanisms underlying differentiation and proliferation of hepatic stem/progenitor cells for development of novel cell transplantation models

2014 - 2018 Elucidation of hepatitis virus infection / replication mechanism using genome-modified human pluripotent stem cells

2015 - 2017 Development of an On-chip Simulator of Hepatic Lobule

2013 - 2017 Pathophysiological Interplay between Liver Fibrosis, Regeneration and Hepatocarcinogenesis from the Viewpoint of Stem/progenitor Cell Differentiation

2013 - 2015 Analyses of intrinsic and extrinsic miRNA regulating proliferation of human iPS cell-derived hepatoblats.

2012 - 2015 Studies on molecular mechanisms regulating fate decision of hepatic stem cells and efficacy of hepatic stem cell transplantation

2012 - 2014 多能性幹細胞由来肝幹・前駆細胞を用いた胆管疾患解析系の構築

2011 - 2014 Establishment of human liver chimeric mice with normal immune system for hepatitis viral infection

2009 - 2010 Analyses of cell-cell interaction regulating proliferation and differentiation of hepatic stem cells during early-liver development

2008 - 2009 Research on molecular mechanism of hepatic stem cell proliferation and development of mouse models for stem cell transplantation

2007 - 2008 Mechanism regulating proliferation and differentiation of liver stem cells

2005 - 2006 肝臓の初期発生および成熟段階における液性因子・細胞外マトリクスの関与

2005 - 2006 Molecular basis of asymmetric division and lineage commitment in hematopoietic stem cells

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Papers (81)：

Takashi Irie, Taito Matsuda, Yoshinori Hayashi, Kanae Matsuda-Ito, Akihide Kamiya, Takahiro Masuda, Marco Prinz, Noriko Isobe, Jun-Ichi Kira, Kinichi Nakashima. Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 42. e2307972120
Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Hidenori Nonaka, Masashi Toyoda, Akihide Kamiya, Tohru Kiyono, Tohru Kimura, Mureo Kasahara, et al. Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells. Progress in molecular biology and translational science. 2023. 199. 155-178
Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Masashi Toyoda, Tohru Kimura, Masahiko Kuroda, Atsuko Nakazawa, Mureo Kasahara, Hidenori Nonaka, et al. Drug metabolic activity is a critical cell-intrinsic determinant for selection of hepatocytes during long-term culture. Stem Cell Research & Therapy. 2022. 13. 1
Akihide Kamiya, Kinuyo Ida. Liver Injury and Cell Survival in Non-Alcoholic Steatohepatitis Regulated by Sex-Based Difference through B Cell Lymphoma 6. Cells. 2022. 11. 23
遠藤整, 志田侑華里, 大和田賢, 稲垣豊, 住吉秀明, 紙谷聡英, 江藤智生, 立道昌幸. THAラット学習行動を制御する代謝物の同定と役割の解明. 日本衛生学雑誌. 2022. 77. Suppl. S178-S178

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MISC (57)：

原貴信, 浜田隆志, 中村アンナ, 曽山明彦, 宮本大輔, 日高匡章, 紙谷聡英, 中山功一, 金高賢悟, 江口晋. Countermeasures against post-liver transplant biliary complications using regenerative medicine approach. 日本再生医療学会総会(Web). 2022. 21st
濱田隆志, 中村アンナ, 曽山明彦, 堺裕輔, 三好敬之, 山口峻, 原貴信, 松島肇, 田中貴之, 足立智彦, et al. 細胞のみで構成される管腔構造体を用いたバイオ人工胆管の作製と移植. 人工臓器. 2020. 49. 2. S-188
Yasuhiro Nakano, Akihide Kamiya, Hideaki Sumiyoshi, Kota Tsuruya, Tatehiro Kagawa, Yutaka Inagaki. REGRESSION OF LIVER FIBROSIS INDUCED BY A NOVEL DEACTIVATION FACTOR OF FIBROGENIC HEPATIC STELLATE CELLS. HEPATOLOGY. 2019. 70. 894A-894A
Takashi Hamada, Anna Nakamura, Akihiko Soyama, Takayuki Miyoshi, Masaaki Hidaka, Koji Natsuda, Mitsuhisa Takatsuki, Akihide Kamiya, Koichi Nakayama, Susumu Eguchi. BILE DUCT RECONSTRUCTION USING SCAFFOLD-FREE TUBULAR CONSTRUCTS OF ALLOGENEIC PIG FIBROBLAST. TRANSPLANT INTERNATIONAL. 2019. 32. 84-84
濱田隆志, 中村アンナ, 曽山明彦, 堺裕輔, 三好敬之, 山口峻, 日高匡章, 夏田孔史, 釘山統太, 大野慎一郎, et al. 再生医療の現状と将来展望細胞のみで構成される管腔構造体を用いたバイオ人工胆管の作製. 移植. 2019. 54. 総会臨時. 142-142

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