Wada Shun'ichi

Affiliation and department：

Research field (2)： Environmental and pharmaceutical development resources , Pharmaceuticals - chemistry and drug development

Research keywords (3)： DDS , 核酸医薬 , 膜透過性ペプチド

Research theme for competitive and other funds (8)：

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Papers (82)：

Junsuke Hayashi, Yosuke Ochi, Kota Senpuku, Shun-Ichi Wada, Fumito Wada, Mariko Harada-Shiba, Hidehito Urata. Rational design of prodrug-type apoB-targeted siRNA for nuclease resistance improvement without compromising gene silencing potency. Bioorganic & medicinal chemistry. 2024. 104. 117693-117693
Norihito Sugimoto, Junsuke Hayashi, Ryohei Funaki, Shun-Ichi Wada, Fumito Wada, Mariko Harada-Shiba, Hidehito Urata. Prodrug-Type Phosphotriester Oligonucleotides with Linear Disulfide Promoieties Responsive to Reducing Environment. Chembiochem : a European journal of chemical biology. 2023. e202300526
Shun-Ichi Wada, Akira Shibaike, Junsuke Hayashi, Hidehito Urata. Influence of Aib-Containing Amphipathic Helical Chain Length in MAP(Aib)-cRGD as Carrier for siRNA Delivery. Chemistry & biodiversity. 2022. 19. 2. e202100728
Tatsuya Funai, Chizuko Tagawa, Osamu Nakagawa, Shun-ichi Wada, Akira Ono, Hidehito Urata. Enzymatic formation of consecutive thymine-HgII-thymine base pairs by DNA polymerases. Chemical Communications. 2020. 56. 80. 12025-12028
Funai T, Aotani M, Kiriu R, Nakamura J, Miyazaki Y, Nakagawa O, Wada SI, Torigoe H, Ono A, Urata H. Silver(I) ion-mediated cytosine-containing base pairs: Metal ion specificity for duplex stabilization and susceptibility toward DNA polymerases. Chembiochem : a European journal of chemical biology. 2020. 21. 4. 517-522

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MISC (5)：

Books (4)：

Lectures and oral presentations (38)：

還元環境に応答するリンカーを有した 5-aminolevulinic acid-環状RGDコンジュゲート体の合成
(日本薬学会第144年会 2024)
EFFECT OF LYSINE REPLACEMENT WITH ARGININE IN AMPHIPATHIC HELICAL PEPTIDE ON siRNA DELIVERY INTO CELLS
(2023)
ApoB標的アンチセンス核酸gap領域へのリン酸トリエステル修飾の導入と活性への影響
(日本核酸医薬学会第8回年会 2023)
ヌクレアーゼ抵抗性改善を目指した部分修飾ApoB標的プロドラッグ型siRNAの設計
(日本薬学会第143年会 2023)
MAP(Aib)のArg置換によるsiRNA細胞内デリバリーへの影響
(日本薬学会第143年会 2023)

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Professional career (1)：

Work history (2)：

Association Membership(s) (3)：

The Japanese Peptide Society , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本薬学会医薬化学部会

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