Tsuchimoto Daisuke

Affiliation and department：

Research field (4)： Immunology , Neuroscience - general , Genetics , Experimental pathology

Research keywords (3)： NEIL3 , ITPA , damaged nucleotides

Research theme for competitive and other funds (8)：

2021 - 2024 イノシン三リン酸分解酵素欠損の分子病態解明
2018 - 2020 Elucidation of molecular pathogenesis of ITPA deficiency and development of its treatment
2017 - 2019 Investigation of brain damage caused by reactive oxygen species and its defense mechanisms
2010 - 2014 Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stress
2011 - 2012 ATPの酸化体によるシグナル伝達

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Papers (59)：

Carol E Schrader, Travis Williams, Klaus Pechhold, Erin K Linehan, Daisuke Tsuchimoto, Yusaku Nakabeppu. APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1. Journal of immunology (Baltimore, Md. : 1950). 2023. 210. 11. 1804-1814
Md Akram Hossain, Yunfeng Lin, Garrett Driscoll, Jia Li, Anne McMahon, Joshua Matos, Haichao Zhao, Daisuke Tsuchimoto, Yusaku Nakabeppu, Jianjun Zhao, et al. APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells. Frontiers in Cell and Developmental Biology. 2021. 9
藤井敬之, 宮地佑希野, 山崎亮, 土本大介, 迫田礼子, 福元尚子, 松下拓也, 中別府雄作, 吉良潤一, 磯部紀子. 間接蛍光抗体法による多発性硬化症患者血清中の抗オリゴデンドロサイト抗体の検討. 神経免疫学. 2021. 26. 1. 122-122
Sugako Oka, Julio Leon, Kunihiko Sakumi, Nona Abolhassani, Zijing Sheng, Daisuke Tsuchimoto, Frank M LaFerla, Yusaku Nakabeppu. MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis. Scientific reports. 2021. 11. 1. 5819-5819
Yi Hu, Chun Yang, Tania Amorim, Mohsin Maqbool, Jenny Lin, Chen Li, Chuanfeng Fang, Li Xue, Ariel Kwart, Hua Fang, et al. Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury. Cancer research. 2021. 81. 3. 713-723

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MISC (102)：

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Patents (1)：

Lectures and oral presentations (43)：

Neural stem cell-specific Itpa knockout causes depolarization, epileptic seizure and early death in mice
(第43回日本神経科学大会 2020)
Neural stem cell specific ITPA deficiency causes depolarization of neurons, resulting in epileptic seizure and early death in mice
(日本分子生物学会年会 2019)
ITPA欠損によるヒトてんかん性脳症のモデルとしての神経幹細胞特異的Itpaノックアウトマウス
(平成30年度「先端モデル動物支援プラットフォーム成果発表会」 2019)
ITPA欠損によるヒトてんかん性脳症のモデルとしての神経幹細胞特異的Itpaノックアウトマウス
(第41回日本日本分子生物学会年会 2018)
Neural stem cell-specific Itpa knockout mouse as a model of human epileptic encephalopathy caused by ITPA deficiency
(The Joint Symposium of the 13th International Symposium of the Institute Network for Biomedical Sciences and the 28th Hot Spring Harbor International Symposium 2018 2018)

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Committee career (2)：

Awards (1)：

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