Juntendo University
Division of Glycobiologics, School of Medicine
Assistant Professor (part time)
Research keywords (5)：
Glycan metabolism
, Glycobiology
, Protein quality control and degradation
, Viral infection
, Cancer
Research theme for competitive and other funds (4)：
2021 - 2025 肺癌における糖鎖分子を標的としたEGFR-TKI耐性克服の試み
2021 - 2024 The importance of NGLY1 on the chemoresistance of triple negative breast cancer
2018 - 2020 Revealing a role of cytoplasmic de-glycosylation in the erythropoiesis
2016 - 2018 Revealing the physiological function of de-N-glycosylating enzymes in mice
Papers (28)：
Akinobu Honda, Katsuhiko Kamada, Junichi Seino, Hiroto Hirayama, Haruhiko Fujihira, Masashi Ueki, Toshiyuki Shiraki, Raymond N Burton-Smith, Kazuyoshi Murata, Nozomi Ishii, et al. Structural characterization of zebrafish Ngly2, an ovary-enriched acid PNGase required for egg free glycan production. The Journal of biological chemistry. 2025. 110906-110906
Stuart Emmerson, Haruhiko Fujihira, Takehiro Suzuki, Naoshi Dohmae, Peter Greimel, Yoshio Hirabayashi, Tadashi Suzuki. Comparative proteomics of HepG2 cells reveals NGLY1 as an important regulator of ferroptosis resistance and iron uptake. PLoS One. 2025. 20. 8. e0328166
Haruhiko Fujihira, Hiroto Hirayama, Tadashi Suzuki. NGLY1 deficiency - clinical features and therapeutic strategy. Journal of Human Genetics. 2025
Hiroto Hirayama, Haruhiko Fujihira, Tadashi Suzuki. Development of new NGLY1 assay systems - toward developing an early screening method for NGLY1 deficiency. Glycobiology. 2024. 34. 11. cwae067
Folding and Quality Control of Glycoproteins
Elsevier 2020
Lectures and oral presentations (7)：
The Role of NGLY1 in Iron Homeostasis and Ferroptosis (*Organize a symposium "Importance of glycosylation on organism homeostasis")
(The 48th Annual Meeting of the Molecular Biology Society of Japan 2025)
Introduction (*Organize a symposium "Common and specie-characteristic glycans in diverse biological species")
(The 47th Annual Meeting of the Molecular Biology Society of Japan 2024)
Relationship between NGLY1 and Disease/Phenomena other than NGLY1 deficiency (*Organize a symposium "Multi-biological phenomena tell the importance of glycosylation ~from the development to diseases~")
(The 46th Annual Meeting of the Molecular Biology Society of Japan 2023)
Unknown relationship between NGLY1 and lipid metabolism (*Organize a Symposium "Multi-phenomena caused by dysregulation of glyco-related molecules/organelles")
(The 45th Annual Meeting of the Molecular Biology Society of Japan 2022)
Broad importance of Ngly1 revealed by mouse model analyses
(The 93rd Annual Meeting of the Japanese Biochemical Society 2020)
2024/09 - The Japanese Society of Carbohydrate Research Carbohydrate Research JSCR43 Poster Award A relationship between NGLY1 and ebolavirus replication
2023/09 - The Japanese Society for Carbohydrate Research Incentive Award
