Rchr
J-GLOBAL ID：201801009450217960
Update date: Oct. 14, 2024
Fujihira Haruhiko
フジヒラ ハルヒコ | Fujihira Haruhiko
Affiliation and department：
Other affiliations (1)：
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Juntendo University
Division of Glycobiologics, School of Medicine
Assistant Professor (part time)
Research keywords (5)：
Glycan metabolism
, Glycosylation
, Protein quality control and degradation
, Viral infection
, Cancer
Research theme for competitive and other funds (4)：
- 2021 - 2024 The importance of NGLY1 on the chemoresistance of triple negative breast cancer
- 2021 - 2024 肺癌における糖鎖分子を標的としたEGFR-TKI耐性克服の試み
- 2018 - 2020 Revealing a role of cytoplasmic de-glycosylation in the erythropoiesis
- 2016 - 2018 Revealing the physiological function of de-N-glycosylating enzymes in mice
Papers (24)：
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Hiroto Hirayama, Haruhiko Fujihira, Tadashi Suzuki. Development of new NGLY1 assay systems - toward developing an early screening method for NGLY1 deficiency. Glycobiology. 2024. 34. 11
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Haruhiko Fujihira, Keiko Sato, Yuji Nishiuchi, Takefumi Murase, Yuka Matsuda, Yukiko Yoshida, Takayuki Kamei, Tadashi Suzuki. ELISA-based highly sensitive assay system for the detection of endogenous NGLY1 activity. Biochemical and biophysical research communications. 2024. 710. 149826-149826
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Haruhiko Fujihira. Mouse Models Reveal the Physiological Functions of Cytosolic Peptide:N-Glycanase, NGLY1. Trends in Glycoscience and Glycotechnology. 2024. 36. 211. E51-E54
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Tadashi Suzuki, Haruhiko Fujihira. NGLY1: A fascinating, multifunctional molecule. Biochimica et biophysica acta. General subjects. 2024. 1868. 2. 130379-130379
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Chengcheng Huang, Junichi Seino, Akinobu Honda, Haruhiko Fujihira, Di Wu, Kyohei Okahara, Shinobu Kitazume, Shuichi Nakaya, Ken Kitajima, Chihiro Sato, et al. Rat hepatocytes secrete free oligosaccharides. The Journal of biological chemistry. 2024. 300. 3. 105712-105712
ｍore...
MISC (9)：
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Fujihira Haruhiko. Development of a glycoRNA Detection Tool and Biological Roles of glycoRNA. Trends in Glycoscience and Glycotechnology. 2023. 35. 207. J89-J89
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Fujihira Haruhiko. The Contribution of NGLY1 and O-GlcNAcylation to Drosophila Gut Homeostasis. Trends in Glycoscience and Glycotechnology. 2022. 34. 201. J97-J97
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藤平 陽彦, 根岸 由紀[正原], 入村 達郎, 鈴木 匡. ますます広がるNGLY1の世界-細胞質の脱糖鎖酵素の多機能性- マウスモデルの分析により明らかになったNgly1の広範な領域での重要性(Broad importance of Ngly1 revealed by mouse model analyses). 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [2S06a-03]
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Haruhiko Fujihira, Yuki Masahara-Negishi, Masaru Tamura, Shigeharu Wakana, Chengcheng Huang, Gen Kondoh, Tadashi Yamashita, Yoko Funakoshi, Tadashi Suzuki. Physiological function of deglycosylating enzymes in mice. GLYCOBIOLOGY. 2014. 24. 11. 1198-1198
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Chengcheng Huang, Yoichiro Harada, Akira Hosomi, Yuki Masahara-Negishi, Junichi Seino, Haruhiko Fujihira, Yoko Funakoshi, Takehiro Suzuki, Naoshi Dohmae, Tadashi Suzuki. Functional studies of cytosolic deglycosylating enzymes in mammalian cells. GLYCOBIOLOGY. 2014. 24. 11. 1188-1188
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Books (1)：
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Folding and Quality Control of Glycoproteins
Elsevier 2020
Lectures and oral presentations (6)：
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Introduction (*Organize a symposium "Common and specie-characteristic glycans in diverse biological species")
(The 47th Annual Meeting of the Molecular Biology Society of Japan 2024)
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Relationship between NGLY1 and Disease/Phenomena other than NGLY1 deficiency (*Organize a symposium "Multi-biological phenomena tell the importance of glycosylation ~from the development to diseases~")
(The 46th Annual Meeting of the Molecular Biology Society of Japan 2023)
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Unknown relationship between NGLY1 and lipid metabolism (*Organize a Symposium "Multi-phenomena caused by dysregulation of glyco-related molecules/organelles")
(The 45th Annual Meeting of the Molecular Biology Society of Japan 2022)
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Broad importance of Ngly1 revealed by mouse model analyses
(The 93rd Annual Meeting of the Japanese Biochemical Society 2020)
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Importance of Ngly1 on adult mouse liver
(The 38th Annual Meeting of 2019)
ｍore...
Awards (3)：
- 2024/09 - The Japanese Society of Carbohydrate Research Carbohydrate Research JSCR43 Poster Award A relationship between NGLY1 and ebolavirus replication
- 2023/09 - The Japanese Society for Carbohydrate Research Incentive Award
- 2022/12 - GlycoTOKYO Incentive Award
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