Rchr
J-GLOBAL ID:201801009481024825
Update date: Apr. 23, 2024
Mori Yutaro
モリ ユウタロウ | Mori Yutaro
Affiliation and department:
Job title:
Tenure-Track Assistant Professor
Research field (5):
Nephrology
, Internal medicine - General
, Clinical pharmacy
, Physiology
, Medical biochemistry
Research keywords (6):
3D culture
, disease modeling
, COVID-19
, diabetic kidney disease
, chronic kidney disease
, autophagy
Research theme for competitive and other funds (19):
- 2023 - 2028 尿細管上皮細胞をターゲットとした新規の糖尿病性腎臓病治療薬の開発
- 2024 - 2027 Elucidation of Pathophysiology and Drug Development for Chronic Kidney Disease by Using Kidney-on-a-chip Derived from Patients
- 2023 - 2026 免疫チェックポイント分子の制御による慢性腎臓病の新規治療法開発
- 2022 - 2026 Drug Discovery for Chronic Kidney Disease Targeting Cellular Senescence and Immune Checkpoint Molecules
- 2023 - 2025 マイクロ流体デバイスを用いた慢性腎臓病患者由来kidney-on-a-chipの樹立
- 2023 - 2025 尿細管オルガノイドを用いた慢性腎臓病病態モデルの開発と病因細胞のプロファイリング
- 2023 - 2024 Development of treatment for diabetic kidney disease by combination of KIM-1 inhibitor and SGLT2 inhibitor
- 2024 - 2024 慢性腎臓病患者由来kidney-on-a-chipの開発
- 2023 - 2024 Elucidation of pathophysiology of diabetic kidney disease focusing on intracellular glucose metabolism
- 2023 - 2024 ヒト患者由来の薬剤腎臓毒性試験プラットフォームの開発
- 2023 - 2024 1. 腎臓・肺の上皮細胞における新型コロナウイルス感染症の新規受容体の同定と創薬/2. 細胞老化や代謝変化に着目した慢性腎臓病・糖尿病性腎臓病の病態解明/3. ヒト摘出腎由来尿細管オルガノイドによる各種の新規腎疾患モデルの作製
- 2022 - 2024 Development of semi-personalized disease modeling based on renal tubular organoids
- 2022 - 2023 初代培養オルガノイドによる薬剤テスト
- 2022 - 2023 細胞老化と免疫チェックポイント分子をターゲットとした慢性腎臓病の病態解明
- 2021 - 2022 Kidney Injury Molecule-1 in Epithelial Repair
- 2020 - 2022 Development of new drug for diabetic kidney disease targeted at KIM-1 and free fatty acids
- 2019 - 2020 Clarifications for pathophysiology of diabetic kidney disease related to KIM-1 and drug discovery
- 2015 - 2018 ハーバード大学との戦略的提携による器官恒常性破綻病態に対する新規治療法の開発
- 2016 - 2017 Elucidation of regulatory mechanism for WNK kinase, blood pressure and electrolytes by autophagy
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Papers (43):
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Yuki Nakao, Yutaro Mori, Makiko Mori, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Yuma Waseda, et al. Human kidney-derived tubular organoid, tubuloid, recapitulates cellular senescence, inflammation and fibrosis by repeated-cisplatin treatment. medRxiv. 2024. 2024.03.17.24304404
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Rena Suzukawa, Shintaro Mandai, Yuta Nakano, Shunsuke Inaba, Hisazumi Matsuki, Yutaro Mori, Fumiaki Ando, View ORCID, ProfileTakayasu Mori, Koichiro Susa, et al. Association between antihypertensive combinations and postoperative mortality and functional decline: a nationwide survey of Japanese adults undergoing major surgeries. medRxiv. 2024. 2024.03.14.24304265
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Ken Ikenouchi, Daiei Takahashi, Shintaro Mandai, Mizuki Watada, Sayumi Koyama, Motoki Hoshino, Naohiro Takahashi, Wakana Shoda, Tamaki Kuyama, Yutaro Mori, et al. Impact of COVID-19 versus other pneumonia on in-hospital mortality and functional decline among Japanese dialysis patients: a retrospective cohort study. Scientific Reports. 2024. 14. 1
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Takuya Fujimaru, Takayasu Mori, Motoko Chiga, Shintaro Mandai, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Koichiro Susa, Yuta Nakano, Takao Shoji, et al. Genetic diagnosis of adult hemodialysis patients with unknown etiology. Kidney International Reports. 2024
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Yuta Nakano, Shintaro Mandai, Shotaro Naito, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, et al. Effect of osteosarcopenia on longitudinal mortality risk and chronic kidney disease progression in older adults. Bone. 2024. 179. 116975-116975
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MISC (87):
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森 槙子, 仲尾 祐輝, 森 雄太郎. 新たな病態モデルとしての尿細管オルガノイド. BIO Clinica. 2024. 39. 5. 57-61
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Nakano Yuta, Mandai Shintaro, Naito Shotaro, Fujiki Tamami, Mori Yutaro, Ando Fumiaki, Mori Takayasu, Susa Koichiro, Iimori Soichiro, Sohara Eisei, et al. 骨サルコペニアが死亡率とCKD進行に及ぼす影響 前向き観察コホート研究(Impact of Osteosarcopenia on Mortality and CKD Progression: A Prospective Observational Cohort Study). 日本腎臓学会誌. 2023. 65. 3. 256-256
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藤丸 拓也, 蘇原 映誠, 森 崇寧, 千賀 宗子, 萬代 新太郎, 中野 雄太, 森 雄太郎, 安藤 史顕, 須佐 紘一郎, 東海林 隆男, et al. 成人期に末期腎不全に至った患者の遺伝的背景の検討. 日本腎臓学会誌. 2023. 65. 3. 262-262
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Makiko Mori, Yuki Nakao, Yutaro Mori. Renal tubular organoids as a new pathophysiological model. The CELL. 2023. 55. 4. 76-79
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柳 智貴, 蘇原 映誠, 菊池 寛昭, 竹内 恒, 須佐 紘一郎, 藤木 珠美, 森 雄太郎, 安藤 史顕, 萬代 新太郎, 森 崇寧, et al. AMP感知機構をバイパスしたAMPK活性化によるCKDの新規治療戦略の発見. 日本腎臓学会誌. 2023. 65. 3. 254-254
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Books (1):
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浮腫 : 塩・水過剰、新たな展開とは?
医薬ジャーナル社 2014 ISBN:9784753227037
Lectures and oral presentations (136):
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寛解後IgA腎症に膜性増殖性糸球体腎炎に伴うネフローゼ症候群を発症し、免疫抑制剤で寛解に至った一例
(第121回日本内科学会講演会 医学生・研修医・専攻医の日本内科学会ことはじめ 2024東京 2024)
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LRBA 複合体はリサイクリングエンドソームにおいてAQP2 を効率的に活性化し尿量を調節する
(第33回バソプレシン・オキシトシン研究会 2024)
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高齢保存期 CKD 患者において骨格筋-骨-腎臓連関に寄与する因子の検討
(第13回腎不全研究会 2023)
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新たな病態モデルとしてのヒト患者由来腎尿細管オルガノイド
(第13回腎不全研究会 2023)
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Monoallelic IFT140 Pathogenic Variants in Adult Polycystic Kidney Disease Patients Without Family History
(Kidney Week 2023 2023)
more...
Education (2):
- 2012 - 2016 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Doctoral Program: Medical and Dental Sciences Track
- 2002 - 2008 Tokyo Medical and Dental University Faculty of Medicine School of Medicine
Professional career (2):
- PhD (Tokyo Medical and Dental University)
- MD (Tokyo Medical and Dental University)
Work history (13):
- 2022/02 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Track of Medical and Dental Sciences Assistant Professor, Tenure Track
- 2020/04 - 2022/01 Japan Society for the Promotion of Science Overseas Research Fellow
- 2018/04 - 2022/01 Harvard Medical School Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital Research Fellow in Medicine (HMS) / Research Fellow (BWH)
- 2016/04 - 2019/03 Tokyo Medican and Dental University Department of Nephrology, Division of Systemic Organ Regulation, Track of Medical and Dental Sciences, Graduate School of Medical and Dental Sciences Adjunct Lecturer
- 2017/04 - 2018/03 Harvard Medical School Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital Research Fellow in Medicine (HMS) / POI Sponsored Collaborator (BWH)
- 2015/11 - 2017/03 Tsuchiura Kyodo General Hospital Associate Physician in Nephrology
- 2015/11 - 2016/05 Namegata District General Hospital (Present: Tsuchiura Kyodo General Hospital Namegata District Medical Center)
- 2015/04 - 2016/03 Tokyo Medical and Dental University Department of Nephrology, Division of Systemic Organ Regulation, Track of Medical and Dental Sciences, Graduate School of Medical and Dental Sciences Research Assistant
- 2012/07 - 2016/03 Tokyo Medical and Dental University Department of Nephrology, Medical Hospital Clinical Assistant
- 2014/04 - 2015/03 Tokyo Medical and Dental University Department of Nephrology, Division of Systemic Organ Regulation, Track of Medical and Dental Sciences, Graduate School of Medical and Dental Sciences Teaching Assistant
- 2010/04 - 2012/03 Tsuchiura Kyodo General Hospital Clinical Fellow in Nephrology
- 2009/04 - 2010/03 Tokyo Medical and Dental University Professional Development Center, Medical Hospital Resident
- 2008/04 - 2009/03 Shuwa General Hospital Resident
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Committee career (4):
- 2020/04 - 現在 The Japanese Society of Internal Medicine Committee Member of Peer Review for Clinical Summary in Board Certification Examination
- 2017/04 - 現在 Japanese Society of Nephrology Councillor
- 2022/04 - 2024/03 Tokyo Medical and Dental University Open Innovation Promotor
- 2015/04 - 2017/03 一般社団法人 日本内科学会 病歴要約1次評価委員
Awards (14):
- 2024/04 - The Japanese Society of Internal Medicine Outstanding Instructor Award A case of nephrotic syndrome associated with membranous proliferative glomerulonephritis in post-remission IgA nephropathy, which went into remission with immunosuppressive drugs
- 2024/01 - バソプレシン・オキシトシン研究会 第33回バゾプレシン・オキシトシン研究会 研究奨励賞 LRBA 複合体はリサイクリングエンドソームにおいてAQP2を効率的に活性化し尿量を調節する
- 2023/11 - Japan Medical Association Medical Research Encouragement Prize of The Japan Medical Association Elucidation of pathophysiology of chronic kidney disease using patient-derived organoids
- 2023/03 - Tokyo Medical Association 2022 Tokyo Medical Association Medical Research Award Encouragement Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2022/06 - Japanese Society of Nephrology Young Investigator Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2022/03 - Tokyo Medical and Dental University Medical Alumni Association The 35th Research Excellence Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2022/02 - Tokyo Medical and Dental University Medical Association 2021 Medical Association Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2018/05 - Brigham and Women's Hospital Cardio-Renal Research Award Proximal tubular uptake of free fatty acid (FFA) by Kidney Injury Molecule-1 (KIM-1) mediates tubulointerstitial disease in diabetic nephropathy (DN)
- 2018/01 - バゾプレシン研究会 第28回バゾプレシン研究会 研究奨励賞 家族歴のない成人多発性腎嚢胞患者における網羅的遺伝子解析を用いた遺伝子診断と臨床所見の検討
- 2017/01 - バゾプレシン研究会 第27回バゾプレシン研究会 研究奨励賞 高カリウムはカリシニューリンを活性化しNa-Cl共輸送体(NCC)を脱リン酸化して尿中カリウム排泄を促進する
- 2016/10 - Japanese Society of Nephrology Award of Excellence, The 46th Eastern Regional Meeting of the Japanese Society of Nephrology
- 2015/01 - バゾプレシン研究会 第25回バゾプレシン研究会 研究奨励賞 AngiotensinIIによる血管平滑筋収縮の新しい機序 -KLHL2-WNK3-SPAK-NKCC1カスケード-
- 2014/07 - Japanese Society of Nephrology Award of Excellence, The 57th Annual Meeting of the Japanese Society of Nephrology
- 2014/03 - Tsuchiura Kyodo General Hospital 2013th Academic Encouragement Award of Internal Medicine
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Association Membership(s) (6):
AMERICAN SOCIETY OF NEPHROLOGY
, JAPANESE SOCIETY OF NEPHROLOGY
, THE JAPANESE SOCIETY FOR DIALYSIS THERAPY
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, The Molecular Biology Society of Japan
, American Heart Association
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