Rchr
J-GLOBAL ID:201801009481024825
Update date: Jan. 15, 2026
Mori Yutaro
モリ ユウタロウ | Mori Yutaro
Affiliation and department:
Job title:
Tenure-Track Assistant Professor
Research field (6):
Biomedical engineering
, Nephrology
, Internal medicine - General
, Clinical pharmacy
, Physiology
, Medical biochemistry
Research keywords (7):
Micro Physiological System
, 3D culture
, disease modeling
, COVID-19
, diabetic kidney disease
, chronic kidney disease
, autophagy
Research theme for competitive and other funds (34):
- 2025 - 2032 慢性腎臓病に対する包括的治療の開発
- 2025 - 2028 Comprehensive Pathophysiological Elucidation of Chronic Kidney Disease Targeting Cellular Senescence and Metabolism
- 2023 - 2028 尿細管上皮細胞をターゲットとした新規の糖尿病性腎臓病治療薬の開発
- 2025 - 2027 腎臓尿細管上皮細胞の細胞老化と代謝変化に着目した慢性腎臓病の病態解明
- 2024 - 2027 炎症、線維化および老化に関する、細胞外小胞(EV)を用いた治療用製剤の開発
- 2024 - 2027 Elucidation of Pathophysiology and Drug Development for Chronic Kidney Disease by Using Kidney-on-a-chip Derived from Patients
- 2026 - 2026 Drug Discovery for Chronic Kidney Disease via Novel Mechanisms
- 2025 - 2026 腎臓尿細管上皮細胞の細胞老化と代謝変化に着目した慢性腎臓病病態解明
- 2025 - 2026 修飾シリカナノ粒子による物理的・化学的刺激を用いた腎臓細胞培養の促進化
- 2025 - 2026 植え込み型人工腎臓の開発
- 2025 - 2026 Development of a non-clinical trial platform using patient-derived kidney microphysiological systems
- 2025 - 2026 患者摘出腎由来尿細管オルガノイドを用いたsemi-personalizedな薬剤の非臨床試験プラットフォーム開発
- 2025 - 2026 1. ヒト摘出腎由来尿細管オルガノイドによる各種新規腎疾患モデルの作製と腎臓模倣システムの開発 2. 細胞老化や代謝変化に着目した慢性腎臓病・糖尿病性腎臓病の病態解明と創薬 3. 腎臓・肺の上皮細胞における新型コロナウイルス感染症の新規受容体の同定と創薬
- 2025 - 2026 患者由来オルガノイドを用いた慢性腎臓病共通病態の探索と創薬
- 2023 - 2026 免疫チェックポイント分子の制御による慢性腎臓病の新規治療法開発
- 2022 - 2026 Drug Discovery for Chronic Kidney Disease Targeting Cellular Senescence and Immune Checkpoint Molecules
- 2025 - Let's make chronic kidney disease “curable” using patient-derived mini-kidneys!
- 2024 - 2025 1. 腎臓・肺の上皮細胞における新型コロナウイルス感染症の新規受容体の同定と創薬 2. 細胞老化や代謝変化に着目した慢性腎臓病・糖尿病性腎臓病の病態解明 3. ヒト摘出腎由来尿細管オルガノイドによる各種の新規腎疾患モデルの作製とkidney-on-a-chip樹立
- 2024 - 2025 患者由来腎臓尿細管オルガノイドのメタボローム解析
- 2023 - 2025 マイクロ流体デバイスを用いた慢性腎臓病患者由来kidney-on-a-chipの樹立
- 2023 - 2025 尿細管オルガノイドを用いた慢性腎臓病病態モデルの開発と病因細胞のプロファイリング
- 2023 - 2024 Development of treatment for diabetic kidney disease by combination of KIM-1 inhibitor and SGLT2 inhibitor
- 2024 - 2024 慢性腎臓病患者由来kidney-on-a-chipの開発
- 2023 - 2024 Elucidation of pathophysiology of diabetic kidney disease focusing on intracellular glucose metabolism
- 2023 - 2024 ヒト患者由来の薬剤腎臓毒性試験プラットフォームの開発
- 2023 - 2024 1. 腎臓・肺の上皮細胞における新型コロナウイルス感染症の新規受容体の同定と創薬/2. 細胞老化や代謝変化に着目した慢性腎臓病・糖尿病性腎臓病の病態解明/3. ヒト摘出腎由来尿細管オルガノイドによる各種の新規腎疾患モデルの作製
- 2022 - 2024 Development of semi-personalized disease modeling based on renal tubular organoids
- 2022 - 2023 初代培養オルガノイドによる薬剤テスト
- 2022 - 2023 細胞老化と免疫チェックポイント分子をターゲットとした慢性腎臓病の病態解明
- 2021 - 2022 Kidney Injury Molecule-1 in Epithelial Repair
- 2020 - 2022 Development of new drug for diabetic kidney disease targeted at KIM-1 and free fatty acids
- 2019 - 2020 Clarifications for pathophysiology of diabetic kidney disease related to KIM-1 and drug discovery
- 2015 - 2018 ハーバード大学との戦略的提携による器官恒常性破綻病態に対する新規治療法の開発
- 2016 - 2017 Elucidation of regulatory mechanism for WNK kinase, blood pressure and electrolytes by autophagy
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Papers (63):
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Yuta Sekiguchi, Makiko Mori, Haruka Maruyama, Yuki Nakao, Hiroaki Kikuchi, Shintaro Mandai, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Yuma Waseda, et al. The pathophysiological mechanism of Beni-koji Choleste-Help/puberulic acid-induced kidney injury. Kidney International Reports. 2026. in press
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Shunsuke Inaba, Takanori Hasegawa, Yuta Nakano, Shotaro Naito, Rena Suzukawa, Takaaki Koide, Hisateru Sekiya, Hisazumi Matsuki, Tamami Fujiki, Hiroaki Kikuchi, et al. Circulating Extracellular Vesicle MicroRNAs as Predictive Biomarkers for Kidney and Cardiovascular Events. Journal of the American Heart Association. 2025. e045148
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Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, et al. A Human Kidney Tubuloid Model of Repeated Cisplatin-Induced Cellular Senescence and Fibrosis for Drug Screening. Advanced Healthcare Materials. 2025
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Yuki Nakao, Junko Kunieda, Towako Taguchi, Yuki Tanaka, Soichiro Iimori, Fumiaki Ando, Shintaro Mandai, Koichiro Susa, Takayasu Mori, Shotaro Naito, et al. Delayed Therapeutic Response to Oral Corticosteroids and Rituximab Leading to Dialysis Independence in a Patient with Treatment-resistant C3 Glomerulonephritis. Internal Medicine. 2025
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Takefumi Suzuki, Koichiro Susa, Hiroaki Kikuchi, Yuta Nakano, Tomoki Yanagi, Yu Hara, Tamami Fujiki, Fumiaki Ando, Shintaro Mandai, Yutaro Mori, et al. iPSC-based drug discovery identified the Hippo signaling pathway as a therapeutic target in the fibrosis of NPHP1-deficient nephronophthisis. Stem Cell Research & Therapy. 2025. in press
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MISC (122):
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仲尾 祐輝, 森 槙子, 森 雄太郎. 慢性腎臓病(CKD)創薬を加速させるヒト患者由来尿細管オルガノイド. BIO Clinica. 2025. 40. 1. 90-95
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鈴木 健文, 須佐 紘一郎, 柳 智貴, 中野 雄太, 原 悠, 藤木 珠美, 菊池 寛昭, 安藤 史顕, 萬代 新太郎, 森 雄太郎, et al. ヒトiPS細胞を用いたネフロン癆病態モデル腎オルガノイドの作製. 日本腎臓学会誌. 2024. 66. 4. 572-572
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中野 雄太, 萬代 新太郎, 森 雄太郎, 安藤 史顕, 森 崇寧, 須佐 紘一郎, 飯盛 聡一郎, 内藤 省太郎, 蘇原 映誠, 伏見 清秀, et al. 急性大動脈解離による国内11年間の緊急透析リスクと性差. 日本腎臓学会誌. 2024. 66. 4. 677-677
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鈴川 礼奈, 萬代 新太郎, 中野 雄太, 森 雄太郎, 安藤 史顕, 森 崇寧, 須佐 絋一郎, 飯盛 総一郎, 内藤 省太郎, 蘇原 映誠, et al. 降圧薬クラスの選択が外科手術後の生命予後・ADL転帰を変える. 日本腎臓学会誌. 2024. 66. 4. 628-628
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藤丸 拓也, 蘇原 映誠, 森 崇寧, 関根 章成, 千賀 宗子, 萬代 新太郎, 菊池 寛昭, 森 雄太郎, 原 悠, 藤木 珠美, et al. PKHD1のヘテロ接合性バリアントは常染色体顕性多発性囊胞腎の原因となり得る. 日本腎臓学会誌. 2024. 66. 4. 627-627
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Books (1):
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浮腫 : 塩・水過剰、新たな展開とは?
医薬ジャーナル社 2014 ISBN:9784753227037
Lectures and oral presentations (221):
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遠位尿細管性アシドーシスに甲状腺機能亢進症を併発し低K血性ミオパチーを呈した一例
(第57回臨床体液研究会 2026)
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AMPKシグナルを基軸とした傷害尿細管修復機序の解明と治療戦略
(第15回腎不全研究会 2025)
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循環細胞外傷法の機能低下測定技術:microRNAプロファイルによる腎・心血管疾患リスク予測モデルの構築
(第15回腎不全研究会 2025)
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ヒトiPS細胞を用いたネフロン癆病態モデル腎オルガノイドの作製と治療薬候補の探索
(第15回腎不全研究会 2025)
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ヒト患者由来人相棒を用いた近位尿細管上皮模倣システムの開発
(第15回腎不全研究会 2025)
more...
Works (2):
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替えきかぬ 細胞だけに 菌生える
森 雄太郎 2024 - 2024
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渾身の 高額実験 ネガデータ
森 雄太郎 2024 - 2024
Education (8):
- 2025 - 現在 Institute of Science Tokyo Medical and Drug Discovery Data Science Consortium Entrepreneur Development Program Standard Course
- 2025 - 2025 Institute of Science Tokyo Medical Innovation Talent Development Program 2025
- 2025 - 2025 Institute of Science Tokyo CUMOT Program Deep Tech Entrepreneur Creation Course
- 2025 - 2025 Institute of Science Tokyo Institute of Integrated Research Center for Fundamental Research, Comprehensive Academy
- 2012 - 2016 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Doctoral Program: Medical and Dental Sciences Track
- 2002 - 2008 Tokyo Medical and Dental University Faculty of Medicine School of Medicine
- 1999 - 2002 青雲高等学校 普通科
- 1996 - 1999 長崎大学教育学部附属中学校
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Professional career (2):
- PhD (Tokyo Medical and Dental University)
- MD (Tokyo Medical and Dental University)
Work history (14):
- 2024/10 - 現在 Institute of Science Tokyo Graduate School of Medical and Dental Sciences Track of Medical and Dental Sciences Tenure-Track Assistant Professor
- 2022/02 - 2024/09 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Track of Medical and Dental Sciences Assistant Professor, Tenure Track
- 2020/04 - 2022/01 Japan Society for the Promotion of Science Overseas Research Fellow
- 2018/04 - 2022/01 Harvard Medical School Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital Research Fellow in Medicine (HMS) / Research Fellow (BWH)
- 2016/04 - 2019/03 Tokyo Medican and Dental University Department of Nephrology, Division of Systemic Organ Regulation, Track of Medical and Dental Sciences, Graduate School of Medical and Dental Sciences Adjunct Lecturer
- 2017/04 - 2018/03 Harvard Medical School Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital Research Fellow in Medicine (HMS) / POI Sponsored Collaborator (BWH)
- 2015/11 - 2017/03 Tsuchiura Kyodo General Hospital Associate Physician in Nephrology
- 2015/11 - 2016/05 Namegata District General Hospital (Present: Tsuchiura Kyodo General Hospital Namegata District Medical Center)
- 2015/04 - 2016/03 Tokyo Medical and Dental University Department of Nephrology, Division of Systemic Organ Regulation, Track of Medical and Dental Sciences, Graduate School of Medical and Dental Sciences Research Assistant
- 2012/07 - 2016/03 Tokyo Medical and Dental University Department of Nephrology, Medical Hospital Clinical Assistant
- 2014/04 - 2015/03 Tokyo Medical and Dental University Department of Nephrology, Division of Systemic Organ Regulation, Track of Medical and Dental Sciences, Graduate School of Medical and Dental Sciences Teaching Assistant
- 2010/04 - 2012/03 Tsuchiura Kyodo General Hospital Clinical Fellow in Nephrology
- 2009/04 - 2010/03 Tokyo Medical and Dental University Professional Development Center, Medical Hospital Resident
- 2008/04 - 2009/03 Shuwa General Hospital Resident
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Committee career (6):
Awards (14):
- 2025/06 - 国立大学法人 東京科学大学 2025年度社会変革チャレンジ賞 患者摘出腎由来尿細管オルガノイドを用いたsemi-personalizedな薬剤の非臨床試験プラットフォーム開発
- 2025/04 - The Japanese Society of Internal Medicine Outstanding Instructor Award A case of delayed response to steroids and rituximab in treatment-resistant C3 nephropathy leading to weaning from dialysis
- 2025/03 - 公益財団法人 加藤記念バイオサイエンス財団 第36 回(2024 年度)加藤記念研究助成 優秀賞 腎臓尿細管上皮細胞の細胞老化と代謝変化に着目した慢性腎臓病の病態解明
- 2024/05 - 株式会社EXORPHIA バイオベンチャーあるある川柳大賞 オーディエンス賞 渾身の 高額実験 ネガデータ
- 2024/04 - The Japanese Society of Internal Medicine Outstanding Instructor Award A case of nephrotic syndrome associated with membranous proliferative glomerulonephritis in post-remission IgA nephropathy, which went into remission with immunosuppressive drugs
- 2023/11 - Japan Medical Association Medical Research Encouragement Prize of The Japan Medical Association Elucidation of pathophysiology of chronic kidney disease using patient-derived organoids
- 2023/03 - Tokyo Medical Association 2022 Tokyo Medical Association Medical Research Award Encouragement Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2022/06 - Japanese Society of Nephrology Young Investigator Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2022/03 - Tokyo Medical and Dental University Medical Alumni Association The 35th Research Excellence Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2022/02 - Tokyo Medical and Dental University Medical Association 2021 Medical Association Award KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
- 2018/05 - Brigham and Women's Hospital Cardio-Renal Research Award Proximal tubular uptake of free fatty acid (FFA) by Kidney Injury Molecule-1 (KIM-1) mediates tubulointerstitial disease in diabetic nephropathy (DN)
- 2016/10 - Japanese Society of Nephrology Award of Excellence, The 46th Eastern Regional Meeting of the Japanese Society of Nephrology
- 2014/07 - Japanese Society of Nephrology Award of Excellence, The 57th Annual Meeting of the Japanese Society of Nephrology
- 2014/03 - Tsuchiura Kyodo General Hospital 2013th Academic Encouragement Award of Internal Medicine
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Association Membership(s) (7):
多発性嚢胞腎協会
, The Molecular Biology Society of Japan
, AMERICAN SOCIETY OF NEPHROLOGY
, JAPANESE SOCIETY OF NEPHROLOGY
, THE JAPANESE SOCIETY FOR DIALYSIS THERAPY
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, American Heart Association
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