Rchr
J-GLOBAL ID：201801009519542469   Update date: Sep. 29, 2025

Koike Nobuya

Koike Nobuya
Affiliation and department：
Kyoto Prefectural University of Medicine

About Kyoto Prefectural University of Medicine


Research field  (1)： Molecular biology
Research keywords  (4)： epigenome ,  transcriptome ,  clock genes ,  Circadian rhythm
Research theme for competitive and other funds  (4)：
  • 2024 - 2027 Analysis of pre-symptomatic pathophysiology in chronic jet-lag mouse model
  • 2019 - 2023 Epigenetic analysis for emergence of mammalian circadian rhythms
  • 2015 - 2018 Developmental mechanisms of circadian clock in mouse embryo
  • 2014 - 2017 Circadian transcriptome analysis for protection against obesity development
Papers (42)：
  • Nobuya Koike, Yasuhiro Umemura, Hitoshi Inokawa, Isao Tokuda, Yoshiki Tsuchiya, Yuh Sasawaki, Atsushi Umemura, Naoko Masuzawa, Kazuya Yabumoto, Takashi Seya, et al. Inter-individual variations in circadian misalignment-induced NAFLD pathophysiology in mice. iScience. 2024. 27. 2. 108934-108934
  • Kazuaki Mawatari, Nobuya Koike, Kazunari Nohara, Marvin Wirianto, Takashi Uebanso, Takaaki Shimohata, Yasuhiro Shikishima, Hiroyuki Miura, Yoshitaka Nii, Mark J Burish, et al. The Polymethoxyflavone Sudachitin Modulates the Circadian Clock and Improves Liver Physiology. Molecular nutrition & food research. 2023. 67. 9. e2200270
  • Hiroko Nakai, Yoshiki Tsuchiya, Nobuya Koike, Taiki Asano, Morio Ueno, Yasuhiro Umemura, Yuh Sasawaki, Ryutaro Ono, Junji Hamuro, Chie Sotozono, et al. Comprehensive Analysis Identified the Circadian Clock and Global Circadian Gene Expression in Human Corneal Endothelial Cells. Investigative ophthalmology & visual science. 2022. 63. 5. 16-16
  • Marvin Wirianto, Chih-Yen Wang, Eunju Kim, Nobuya Koike, Ruben Gomez-Gutierrez, Kazunari Nohara, Gabriel Escobedo Jr, Jong Min Choi, Chorong Han, Kazuhiro Yagita, et al. The clock modulator Nobiletin mitigates astrogliosis-associated neuroinflammation and disease hallmarks in an Alzheimer's disease model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022. 36. 3. e22186
  • 小池 宣也, 梅村 康浩, 井之川 仁, 笹脇 ゆふ, 土谷 佳樹, 八木田 和弘. 階層を超えた包括的フェノタイプ解析による概日リズム障害成立プロセスの解明. 日本生理学雑誌. 2022. 84. 1. 30-30
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MISC (24)：
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Lectures and oral presentations  (2)：
  • 概日転写サイクルとクロマチンランドスケープ
    (第38回日本分子生物学会年会 2015)
  • 概日転写制御機構とシストローム,エピゲノム
    (第35回日本分子生物学会年会 2012)
Education (3)：
  • 1998 - 2002 東京大学大学院 医学研究科 分子細胞生物学専攻
  • 1996 - 1998 Tokyo University of Science
  • 1992 - 1996 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy
Professional career (1)：
  • 博士(医学) (東京大学)
Work history (6)：
  • 2014/01 - 現在 Kyoto Prefectural University of Medicine Graduate School of Medical Science
  • 2013/06 - 2013/12 Kyoto Prefectural University of Medicine Graduate School of Medical Science
  • 2009/04 - 2013/05 University of Texas Southwestern Medical Center Department of Neuroscience Senior Research Associate
  • 2004/04 - 2009/03 三菱化学生命科学研究所 時間ゲノム学 特別研究員
  • 2002/04 - 2004/03 The University of Tokyo The Institute of Medical Science
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Association Membership(s) (3)：
THE PHYSIOLOGICAL SOCIETY OF JAPAN ,  JAPANESE SOCIETY FOR CHRONOBIOLOGY ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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