Rchr
J-GLOBAL ID：201801009684484295
Update date: Jan. 30, 2024
Masuya Takahiro
Masuya Takahiro
Affiliation and department：
Research field (1)：
Bioorganic chemistry
Research keywords (4)：
Bioorganic chemistry
, Chemistry of natural product
, Respiratory chain
, Chemical biology
Research theme for competitive and other funds (3)：
- 2022 - 2024 Elucidation of sodium translocation mechanism of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae
- 2020 - 2022 Inhibition mechanism of IACS-010759 on mitochondrial respiratory complex I, a potent inhibitor of hypoxic tumor cells
- 2015 - 2017 呼吸鎖複合体-Iの1分子計測を目指したプローブ分子の創製と特異的化学修飾法の確立
Papers (20)：
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Ryo Ikunishi, Ryohei Otani, Takahiro Masuya, Kyoko Shinzawa-Itoh, Tomoo Shiba, Masatoshi Murai, Hideto Miyoshi. Respiratory complex I in mitochondrial membrane catalyzes oversized ubiquinones. Journal of Biological Chemistry. 2023. 105001-105001
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Atsuhito Tsuji, Takahiro Masuya, Norihito Arichi, Shinsuke Inuki, Masatoshi Murai, Hideto Miyoshi, Hiroaki Ohno. Discovery of Bis-sulfonamides as Novel Inhibitors of Mitochondrial NADH-Quinone Oxidoreductase (Complex I). ACS Medicinal Chemistry Letters. 2023. 14. 2. 211-216
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Jun-ichi Kishikawa, Moe Ishikawa, Takahiro Masuya, Masatoshi Murai, Yuki Kitazumi, Nicole L. Butler, Takayuki Kato, Blanca Barquera, Hideto Miyoshi. Cryo-EM structures of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae. Nature Communications. 2022. 13. 1
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Moe Ishikawa, Takahiro Masuya, Seina Kuroda, Shinpei Uno, Nicole L. Butler, Sara Foreman, Masatoshi Murai, Blanca Barquera, Hideto Miyoshi. The side chain of ubiquinone plays a critical role in Na+ translocation by the NADH-ubiquinone oxidoreductase (Na+-NQR) from Vibrio cholerae. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2022. 1863. 5. 148547-148547
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Shinpei Uno, Takahiro Masuya, Oleksii Zdorevskyi, Ryou Ikunishi, Kyoko Shinzawa-Itoh, Jonathan Lasham, Vivek Sharma, Masatoshi Murai, Hideto Miyoshi. Diverse reaction behaviors of artificial ubiquinones in mitochondrial respiratory complex I. Journal of Biological Chemistry. 2022. 102075-102075
ｍore...
Lectures and oral presentations (58)：
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ミトコンドリア呼吸鎖複合体-Iを阻害するアセトゲニンの結合部位の同定
(日本農芸化学会2023年度大会 2023)
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クライオ電子顕微鏡によるコレラ菌Na+輸送性NADH-ユビキノン酸化還元酵素の構造解明
(日本農芸化学会2023年度大会 2023)
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人工キノン類を用いた呼吸鎖複合体-Iのキノン結合ポケットに関する研究
(日本農芸化学会2023年度大会 2023)
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ミトコンドリア呼吸鎖複合体-Iにおける脱共役ユビキノン類の作用機構
(日本農芸化学会2023年度大会 2023)
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コレラ菌Na+輸送性NADH-ユビキノン酸化還元酵素におけるユビキノン側鎖の結合部位の同定
(日本農薬学会第48回大会 2023)
ｍore...
Education (3)：
- 2014 - 2017 Kyoto University Graduate School of Agriculture Division of Applied Life Sciences
- 2012 - 2014 Kyoto University Graduate School of Agriculture Division of Applied Life Sciences
- 2008 - 2012 Kyoto University Faculty of Agriculture
Professional career (1)：
Work history (4)：
- 2021/11 - 現在 Kyoto University Graduate School of Agriculture Assistant Professor
- 2018/12 - 2021/10 Kyoto University Graduate School of Agriculture
- 2017/04 - 2018/11 University of Shizuoka School of Pharmaceutical Sciences
- 2015/04 - 2017/03 日本学術振興会特別研究員(DC2)
Committee career (1)：
- 2021/04 - 現在 日本農薬学会 農薬デザイン研究会委員
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