Rchr
J-GLOBAL ID：201801009825388155   Update date: Apr. 19, 2024

HARA Kodai

ハラ コウダイ | HARA Kodai
Affiliation and department：
University of Shizuoka School of Pharmaceutical Sciences

About University of Shizuoka School of Pharmaceutical Sciences


Job title： Associate Professor
Research field  (2)： Structural biochemistry ,  Pharmaceuticals - analytical and physicochemistry
Research keywords  (5)： Structural Biology ,  Xray Crystallography ,  Chromosome ,  DNA Repair ,  Natural Products Chemistry
Research theme for competitive and other funds  (9)：
  • 2024 - 2027 ミスマッチ修復を促進するクロマチンリモデラーの構造生物学的解明
  • 2023 - 2026 肝星細胞における液ー液相分離を標的としたNASH進行スイッチ制御の確立
  • 2023 - 2026 Structural basis for stimulation of DNA damage checkpoint by 9-1-1 interacting protein RHINO
  • 2020 - 2024 脊椎動物の染色体凝縮を担うコンデンシンの構造基盤と動的挙動の解明
  • 2021 - 2023 ミスマッチ修復におけるゲノムモダリティの構造生物学的解明
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Papers (36)：
  • Matsushita T, Kishimoto S, Hara K, Hashimoto H, Yamaguchi H, Saito Y, Watanabe K. Functional enhancement of flavin-containing monooxygenase through machine learning methodology. ACS Catalysis. 2024. 14. 6945-6951
  • Hara K, Tatsukawa K, Nagata K, Iida N, Hishiki A, Ohashi E, Hashimoto H. Structural basis for intra- and inter-molecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO. The Journal of biological chemistry. 2024. 300. 3. 105751
  • Sato M, Sakano S, Nakahara M, Tamura Y, Hara K, Hashimoto H, Tang Y, Watanabe K. Uncommon arrangement of self-resistance allows biosynthesis of de novo purine biosynthesis inhibitor that acts as an immunosuppressor. Journal of the American Chemical Society. 2023. 145. 49. 26883-26889
  • Hara K, Hishiki A, Hoshino T, Nagata K, Iida N, Sawada Y, Ohashi E, Hashimoto H. The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO. The Journal of biological chemistry. 2023. 299. 4. 103061
  • Hishiki A, Okazaki S, Hara K, Hashimoto H. Crystal structure of sliding clamp of Gram-positive anaerobic bacterium Clostridioides difficile. The journal of biochemistry. 2022. 173. 1. 13-20
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MISC (8)：
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Lectures and oral presentations  (24)：
  • チェックポイントクランプのRAD1サブユニットを介したクランプローダーとの相互作用の構造生物学的解明
    (第27回 DNA複製・組換え・修復ワークショップ 2023)
  • DNA clamp構造生物学研究の新展開
    (東京農業大学大学院講義 細胞分子機能科学(バイオ専攻) 2023)
  • Structural basis for genome modality of DNA mismatch repair
    (2022)
  • Structural basis for genome modality of DNA mismatch repair
    (Genome modality Understanding physical properties of the genome 2021)
  • シミ・そばかすの原因タンパク質のX線結晶構造解析
    (東京農業大学大学院講義 2021)
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Education (4)：
  • 2007 - 2010 Yokohama City University International Graduate School of Arts and Sciences Doctoral Course
  • 2005 - 2007 Yokohama City University International Graduate School of Arts and Sciences Master's Course
  • 2001 - 2005 Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Bio-Science
  • 1997 - 2000 Chiba Higashi High School
Professional career (1)：
  • Doctor of Science (Yokohama City University)
Work history (5)：
  • 2021/10 - 現在 University of Shizuoka School of Pharmaceutical Sciences Associate Professor
  • 2018/10 - 2021/09 University of Shizuoka School of Pharmaceutical Sciences Lecturer
  • 2014/01 - 2018/09 University of Shizuoka School of Pharmaceutical Sciences Assistant Professor
  • 2011/07 - 2013/12 University of Texas Southwestern Medical Center Postdoctoral Researcher
  • 2010/04 - 2011/06 University of Minnesota Postdoctoral Researcher
Committee career (13)：
  • 2023/10 - 現在 University of Shizuoka Editorial Board Member, Journal of Lifelong Well-being Sciences
  • 2024/03 - 日本薬学会第144年会(横浜) ポスター発表学生優秀発表賞審査員
  • 2023/06 - 第27回 DNA複製・組換え・修復ワークショップ 座長
  • 2019/04 - 2021/03 The Pharmaceutical Society of Japan Editorial Board Member, Farumashia
  • 2021/03 - 日本薬学会第141年会(広島) ポスター発表学生優秀発表賞審査員
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Awards (1)：
  • 2018/06 - Award for encouragement of research in the Tokai branch of pharmaceutical society of Japan
Association Membership(s) (4)：
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
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