Araya Jun

アラヤジュン | Araya Jun

Affiliation and department：

Research field (1)： Other

Research theme for competitive and other funds (27)：

2023 - 2026 難治性気管支喘息に対するSenotherapyの開発
2022 - 2025 COPD病態におけるcGAS-STINGの重要性
2022 - 2025 Development of a novel therapeutic agent of EV for pulmonary fibrosis by inducing lipofibroblast differentiation
2021 - 2024 TFEB活性化を介したオートファジーを標的とするIPFとCOPDの治療法開発
2021 - 2024 慢性閉塞性肺疾患におけるCell Fate Commitmentに関する研究

2021 - 2024 COPDにおける新規2型肺胞上皮細胞サブグループを介した病態解明

2020 - 2023 Mieap液滴によるCOPD病態の制御

2020 - 2023 脂質酸化をターゲットとしたCOPD創薬基盤研究

2020 - 2023 involvement of microRNA in the pathogenesis of COPD related sarcopenia

2018 - 2023 慢性閉塞性肺疾患におけるImmunosenescence(免疫老化)に関する研究

2019 - 2022 Aggresome-selective autophagy (aggrephagy) by TOLLIP in IPF.

2019 - 2022 mitochondria UPR in Idiopathic interstitial pneumonia

2019 - 2022 Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia

2018 - 2021 Impaired lysophagy in COPD pathogenesis.

2017 - 2020 Involvement of dendritic cells autophagy in the pathogenesis of COPD

2017 - 2020 Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

2017 - 2020 Chaperone-mediated autophagy modulates epithelial cell apoptosis in COPD pathogenesis

2015 - 2018 Study on the refractory mechanism in inflammatory obstructive lung disease

2015 - 2018 Intracellular communication mediated by exosomal micro RNA in aging-related lung diseases

2015 - 2018 Involvement of Lamin B1 reduction in accelerated cellular senescence during COPD pathogenesis.

2015 - 2018 Clinical evaluation of PGE-MUM as a biomarker in IPF

2013 - 2016 Role of mitophagy in inflammasome activation during COPD pathogenesis.

2012 - 2015 The significance of signaling pathways by exososme in lung injury and fibrosis

2012 - 2015 Study on the molecular and cellular markers associated with clinical phenotype of COPD

2011 - 2013 The cell fate regulated by autophagy and ER stress in idiopathic pulmonary fibrosis.

2009 - 2011 Molecular mechanisms and roles of cell senescence in lung injury and repair

2009 - 2010 The role of autophagic regulation of cellular senescence in COPD pathogenesis

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Papers (200)：

Shota Fujimoto, Yuta Hirano, Naoaki Watanabe, Sachi Matsubayashi, Shun Inukai, Saiko Nishioka, Masahiro Yoshida, Saburo Ito, Shunsuke Minagawa, Hiromichi Hara, et al. Lipogenic Lung Fibroblast-derived Extracellular Vesicles Mitigate Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease Pathologies through LAT1-mediated Alveolar Type II Cell Restoration. 2024
Tsukasa Hasegawa, Kai Ryu, Taiki Fukuda, Yuko Mizobuchi, Lynn Yoshimatsu, Ryo Sato, Makiko Takatsuka, Kyota Shinfuku, Masami Yamada, Yumie Yamanaka, et al. Ultrasonic humidifier lung with a reversed halo sign: A case report. Radiology case reports. 2024. 19. 6. 2520-2524
Yu Fujita, Tsukasa Kadota, Reika Kaneko, Yuta Hirano, Shota Fujimoto, Naoaki Watanabe, Ryusuke Kizawa, Takashi Ohtsuka, Kazuyoshi Kuwano, Takahiro Ochiya, et al. Mitigation of acute lung injury by human bronchial epithelial cell-derived extracellular vesicles via ANXA1-mediated FPR signaling. Communications Biology. 2024
Takanori Numata, Keitaro Okuda, Hanae Miyagawa, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara, Jun Araya. Clinical features in patients with COVID-19 treated with biologics for severe asthma. The journal of allergy and clinical immunology. Global. 2024. 3. 2. 100219-100219
Ryusuke Kizawa, Jun Araya, Yu Fujita. Divergent roles of the Hippo pathway in the pathogenesis of idiopathic pulmonary fibrosis: tissue homeostasis and fibrosis. Inflammation and regeneration. 2023. 43. 1. 45-45

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MISC (119)：

松林沙知, 保坂悠介, 伊藤三郎, 荒屋潤, 平野悠太, 藤本祥太, 川本浩徳, 渡邉直昭, 藤田雄, 竹越大輔, et al. Senotherapuetic approach with autophagy-lysosome regulation in COPD pathogenesis. 日本呼吸器学会誌(Web). 2023. 12
渡邉直昭, 渡邉直昭, 藤田雄, 藤本祥太, 石黒卓, 高橋伸政, 清水禎彦, 高柳昇, 河端美則, 荒屋潤, et al. Spatial transcriptome analysis reveals therapeutic targets for IPF. 日本呼吸器学会誌(Web). 2023. 12
藤本祥太, 藤田雄, 藤田雄, 荒屋潤, 桑野和善. Lipofibroblast derived-extracellular vesicles attenuate pulmonary fibrosis. 日本呼吸器学会誌(Web). 2023. 12
藤田雄, 藤田雄, 荒屋潤, 桑野和善. Extracellular vesicle/exosome-based therapeutics for pulmonary fibrosis. 日本臨床. 2022. 80. 9
山田尭徳, 内海裕文, 山田千枝里, 根本暉久, 内山翔太, 齊藤晋, 奥田慶太郎, 渡部淳子, 高橋直子, 宮川英恵, et al. PD-1/PD-L1阻害薬無効後のイピリムマブ+ニボルマブによる免疫チェックポイント阻害薬再投与についての検討. 日本肺癌学会学術集会号. 2022. 63rd (CD-ROM)

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