Research theme for competitive and other funds (13):
2023 - 2026 Elucidation of the molecular mechanism and physiological significance of retrograde glucose transport in the intestine.
2022 - 2024 メトホルミンが生体内の金属動態に与える影響およびその意義の解明
2021 - 2024 メトホルミンによる腸管腔内へのグルコース排泄機構の解明
2022 - 2023 消化管における逆行性グルコース輸送機構の包括的解析
2020 - 2023 鉄キレート作用を介したメトホルミンによる新規耐糖能改善メカニズムの解明
2021 - 2022 腸管へのグルコース排泄による新規糖代謝制御機構の解明
2020 - 2022 金属キレート作用を活用した抗糖尿病治療薬開発
2019 - 鉄キレート作用を介したメトホルミンの新規作用機序の解明
2019 - 鉄キレート作用を介したメトホルミンによる新規耐糖能改善メカニズムの解明
2016 - 2019 ケミカルプロテオミクスによる新規インスリン分泌増強メカニズムの解明
2015 - 2016 新規糖尿病治療薬としてのEpac2A活性化化合物の同定
2013 - 2016 新規糖尿病治療薬としてのEpac2A活性化化合物の同定
2014 - 2015 新規糖尿病治療薬としてのEpac2A活性化化合物の同定
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Papers (23):
Quan Yingyue, Kenji Sugawara, Harumi Takahashi, Norihide Yokoi, Kento Ohbayashi, Yusaku Iwasaki, Susumu Seino, Wataru Ogawa. Stimulatory effect of imeglimin on incretin secretion. Journal of diabetes investigation. 2023. 14. 6. 746-755
Kyosuke Sato, Kenji Sugawara, Wataru Ogawa. A novel view of the insulin signaling pathway based on prediction of protein structure by the AI platform AlphaFold. Journal of diabetes investigation. 2023
Kaori Hozumi, Kenji Sugawara, Takaya Ishihara, Naotada Ishihara, Wataru Ogawa. Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes. Scientific reports. 2023. 13. 1. 746-746
Kenji Sugawara, Wataru Ogawa. New mechanism of metformin action mediated by lysosomal presenilin enhancer 2. Journal of diabetes investigation. 2022
Kei Yoshino, Yushi Hirota, Wataru Ogawa, Kenji Sugawara, Akira Kawaguchi, Hiroshi Yoshino, Midori Ishibashi, Gen Yoshino, Masafumi Koga. A case of α-chain variant hemoglobin (Hb Chad) with falsely high HbA1c levels measured by immunoassay. Diabetology international. 2022. 13. 1. 330-335
Myofiber Piezo1 regulates muscle hypertrophy and metabolism in response to exercise
(60th EASD Annual Meeting of the European Association for the Study of Diabetes (Madrid, Spain) 2024)
Similarity and difference of intestinal actions of metformin and imeglimin
(59th EASD Annual Meeting)
Effects of Imeglimin on Mitochondrial Function, AMPK Activation, and Gene Expression in Hepatocytes and Myocytes
(The 50th European Muscle Conference)
Quantitative analysis of metformin-induced glucose excretion in the intestine
(The 83rd American Diabetes Association Scientific Sessions.)
Chronic arsenic exposure impairs pancreatic beta cell function.
(Society of Environmental Toxicology and Chemistry Conference (Brussel, Belgium) 2017)