Research theme for competitive and other funds (5)：
2021 - 2024 Understanding of sarcopenia obesity by epigenomic regulation
2019 - 2021 Regulatory mechanism of beige adipocyte-differentiation by protein phosphatase.
2016 - 2018 Understanding of molecular mechanism for overgrowth of the cells in adrenal zona glomerulosa
2016 - 2018 Innovation of novel therapeutics against diabetic nephropathy targeting ChREBP
2014 - 2016 Establishment of the isolation-method of adrenal zona gromerulosa and the analysis of CYP11B2 gene regulation.
Papers (28)：
Hiroki Takahashi, Ryo Ito, Yoshihiro Matsumura, Juro Sakai. Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways. BioEssays : news and reviews in molecular, cellular and developmental biology. 2024. 46. 2. e2300084
Yuki Ono, Ryo Ito, Kaito Arai, Gurdeep Singh, Tsuyoshi Saitoh, Robert B Russell, Francesco Raimondi, Junken Aoki, Juro Sakai, Asuka Inoue. Chemogenetic activation of G12 signaling enhances adipose tissue browning. Signal transduction and targeted therapy. 2023. 8. 1. 307-307
Hiroki Takahashi, Ge Yang, Takeshi Yoneshiro, Yohei Abe, Ryo Ito, Chaoran Yang, Junna Nakazono, Mayumi Okamoto-Katsuyama, Aoi Uchida, Makoto Arai, et al. MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis. Nature communications. 2022. 13. 1. 5715-5715
Yoshihiro Matsumura, Ryo Ito, Ayumu Yajima, Rei Yamaguchi, Toshiya Tanaka, Takeshi Kawamura, Kenta Magoori, Yohei Abe, Aoi Uchida, Takeshi Yoneshiro, et al. Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis. Nature communications. 2021. 12. 1. 7045-7045
Satoshi Saijoh, Mao Nakamura-Shima, Rie Shibuya-Takahashi, Ryo Ito, Akira Sugawara, Tomoko Yamazaki, Takayuki Imai, Yukinori Asada, Kazuto Matsuura, Wataru Iwai, et al. Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein. Biochemical and Biophysical Research Communications. 2021. 537. 132-139
