Rchr
J-GLOBAL ID：201801010591584131   Update date: Sep. 29, 2024

Yoshida Yohko

ヨシダ ヨウコ | Yoshida Yohko
Affiliation and department：
Juntendo University Graduate School of Medicine, Department of Advanced Senotherapeutics

About Juntendo University Graduate School of Medicine, Department of Advanced Senotherapeutics


Job title： Associate professor
Research field  (2)： Metabolism and endocrinology ,  Cardiology
Research keywords  (4)： 動脈硬化 ,  Metabolic disease ,  Heart failure ,  Aging
Research theme for competitive and other funds  (7)：
  • 2022 - 2025 加齢性疾患におけるコリン代謝不全の病的意義の解明
  • 2019 - 2022 Mechanism of white adipose tissue beiging through the modulation of glycolysis
  • 2019 - 2021 Senolysis ameliorates pathologies in atrial fibrillation
  • 2017 - 2019 The pathological role of secreted protein in promoting fibrosis in non alcoholic steatohepatitis.
  • 2016 - 2019 Brown adipose tissue dysfunction promotes metabolic disorder in a failing heart.
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Papers (45)：
  • Yung Ting Hsiao, Yohko Yoshida, Shujiro Okuda, Manabu Abe, Seiya Mizuno, Satoru Takahashi, Hironori Nakagami, Ryuichi Morishita, Kenya Kamimura, Shuji Terai, et al. PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis. The EMBO Journal. 2024
  • Goro Katsuumi, Ippei Shimizu, Masayoshi Suda, Yohko Yoshida, Takaaki Furihata, Yusuke Joki, Chieh-Lun Hsiao, Liang Jiaqi, Shinya Fujiki, Manabu Abe, et al. SGLT2 inhibition eliminates senescent cells and alleviates pathological aging. Nature aging. 2024
  • Ryo Furuuchi, Ippei Shimizu, Yohko Yoshida, Goro Katsuumi, Masayoshi Suda, Yoshiaki Kubota, Kenneth Walsh, Tohru Minamino. Endothelial SIRT-1 has a critical role in the maintenance of capillarization in brown adipose tissue. iScience. 2022. 25. 11. 105424-105424
  • Yohko Yoshida, Ippei Shimizu, Atsuhiro Shimada, Keita Nakahara, Sachiko Yanagisawa, Minoru Kubo, Shinji Fukuda, Chiharu Ishii, Hiromitsu Yamamoto, Takamasa Ishikawa, et al. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. Scientific Reports. 2022. 12. 1
  • Yohko Yoshida, Ippei Shimizu, Tohru Minamino. Capillaries as a Therapeutic Target for Heart Failure. Journal of atherosclerosis and thrombosis. 2022. 29. 7. 971-988
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MISC (183)：
  • Goro Katsuumi, Masayoshi Suda, Ippei Shimizu, Yohko Yoshida, Takaaki Furihata, Yusuke Joki, Chieh Lun L Hsiao, Tohru Minamino. Abstract 14285: Sodium Glucose Co-Transporter 2 Inhibition Eliminates Senescent Cells Through Downregulation of PD-L1 and Improves Pathological Aging. Circulation. 2023. 148. Suppl_1
  • 古内 亮, 清水 逸平, 吉田 陽子, 南野 徹. 内皮SIRT-1は褐色脂肪組織における毛細血管の維持に重要な役割を果たす(Endothelial SIRT-1 Plays an Important Role in the Maintenance of Capillary in Brown Adipose Tissue). 日本循環器学会学術集会抄録集. 2023. 87回. PJ016-2
  • 蕭捷倫, 勝海悟郎, 須田将吉, 清水逸平, 吉田陽子, 降旗高明, 上木裕介, 古内亮, 蕭詠てい, 唐敬遠, et al. Vaccination for senescence-associated glycoprotein ameliorates Alzheimer’s pathology and cognitive behavior in mice. 日本抗加齢医学会総会プログラム・抄録集. 2023. 23rd
  • 清水 逸平, 吉田 陽子, 南野 徹. 【老化はなぜ進むのか Why do we age?】心疾患と老化. BIO Clinica. 2022. 37. 14. 1293-1297
  • 清水 逸平, 吉田 陽子, 南野 徹. 代謝制御と変容、その生物学的意義-心不全治療法開発に向けたアイデア- コリン代謝制御による心不全治療. 血管. 2022. 45. 1. 37-37
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Lectures and oral presentations  (89)：
  • Brown adipose tissue (BAT) dysfunction and BAT-derived metabolite as a therapeutic target for heart failure.
    (第88回日本循環器学会学術集会, 会長特別企画(Special Session 12); Heart failure: From Bench to Bedside 2024)
  • 褐色脂肪由来代謝産物を標的とした新たな心不全治療の開発
    (脳心血管抗加齢研究会第19回学術大会, シンポジウム【多臓器・多細胞連関の視点から明らかとなる加齢関連疾患の治療標的】 2023)
  • 老化シグナルを介した心血管代謝疾患の発症メカニズムの解明
    (第46回日本分子生物学会年会, シンポジウム 3【心血管生物学の新潮流】 2023)
  • 細胞老化を標的とした肥満、糖尿病の新規治療法の開発
    (第44 回日本肥満学会・第41回日本肥満症治療学会学術集会, JASSOシンポジウム 7 2023)
  • 加齢性疾患における腸内細菌由来代謝物質の意義
    (第46回日本基礎老化学会大会, シンポジウム 6【腸内細菌と健康寿命】 2023)
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Awards (21)：
  • 2022/10 - The 29th Scientific Meeting of International Society of Hypertension Best Poster Presentation Award Brown adipose tissue dysfunction promotes metabolic disorder in a failing heart
  • 2021/03 - 第24回日本心血管内分泌代謝学会学術総会 高峰譲吉研究奨励賞 老化シグナルを介した心血管代謝疾患の発症メカニズムの解明
  • 2021 - 新潟大学 令和2年度新潟大学優秀論文表彰 Peptide vaccine for semaphorin 3E ameliorates systemic glucose intolerance in mice with dietary obesity, Scientific Reports (2019)
  • 2020/08 - 第84回日本循環器学会学術集会 YIA優秀賞 Brown adipose tissue dysfunction promotes metabolic disorder in a failing heart
  • 2018/10 - 第39回日本肥満学会 Kobe International Award Vaccination Therapy against Semaphorin 3E Ameliorates Glucose Intolerance in Diet-induced Obese Mice
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