Mihara Keichirou

Affiliation and department：

Research field (1)： Hematology and oncology

Research theme for competitive and other funds (6)：

2022 - 2025 メモリー様分化誘導を基盤とした多種類のがんに有効なCAR-NK細胞製剤の新規開発
2022 - 2025 多発性骨髄腫のマクロファージ活性化と協調効果を示すiPSキラーCAR-Tの開発
2022 - 2025 メモリー様分化誘導を基盤とした多種類のがんに有効なCAR-NK細胞製剤の新規開発
2019 - 2023 ZIP10を標的とした癌転移開始細胞の抑制を基盤とした新しい抗転移療法
2008 - 2010 Drug-resistant genes downstream of Polycomb group genes in leukemia stem cells

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Papers (87)：

Takanori Kubo, Kazuyoshi Yanagihara, Yoshio Nishimura, Yuki Iino, Teruo Komatsu, Rina Tansou, Keichiro Mihara, Toshio Seyama. Antitumor Effect of Oleoyl-siRNA against Pancreatic Cancer Using a Portal Vein Infusion Liver-Metastatic Mouse Model. Molecular pharmaceutics. 2024
Chisako Iriyama, Kenichiro Murate, Sachiko Iba, Akinao Okamoto, Naoe Goto, Hideyuki Yamamoto, Toshiharu Kato, Keichiro Mihara, Takahiko Miyama, Keiko Hattori, et al. Utility of cerebrospinal fluid liquid biopsy in distinguishing CNS lymphoma from cerebrospinal infectious/demyelinating diseases. Cancer medicine. 2023. 12. 16. 16972-16984
Hideyuki Yamamoto, Yuki Mizutani, Chisako Iriyama, Naoe Goto, Akinao Okamoto, Toshiharu Kato, Chiyo Shintani, Naoki Yamamoto, Takahiko Miyama, Keichiro Mihara, et al. Acute fulminant intravascular hemolysis induced by Clostridium perfringens in a symptomatic multiple myeloma patient under immuno-chemotherapy. Annals of hematology. 2022. 101. 12. 2813-2815
Yudai Murayama, Yasushi Kasahara, Nobuhiro Kubo, Chansu Shin, Masaru Imamura, Naoki Oike, Takashi Ariizumi, Akihiko Saitoh, Minori Baba, Tomohiro Miyazaki, et al. NKp44-based chimeric antigen receptor effectively redirects primary T cells against synovial sarcoma. Translational oncology. 2022. 25. 101521-101521
Toshifumi Hara, Yuuki Tominaga, Koji Ueda, Keichiro Mihara, Kazuyoshi Yanagihara, Yoshifumi Takei. Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers. Biochemistry and biophysics reports. 2022. 30. 101255-101255

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MISC (8)：

湛増里奈, 久保貴紀, 西村良夫, 大野美季, 谷口佳隆, 柳原五吉, 柳原五吉, 三原圭一朗, 瀬山敏雄. RNAi efficacy of lipid-conjugated siRNAs against immune checkpoint. 日本核酸医薬学会年会講演要旨集(CD-ROM). 2023. 8th
木下直人, 上野弘貴, 山田英忠, 原直之, 青木志郎, 三原圭一郎, 城間紀之, 有廣光司, 山崎文之, 栗栖薫, et al. 中枢神経原発移植後リンパ増殖性疾患に対しリツキシマブが奏功した62歳女性例. 臨床神経学. 2017. 57. 5. 252-252
上野弘貴, 上村鉄平, 三原圭一朗, 野坂亮, 山崎文之, 越智一秀, 丸山博文, 有廣光司, 栗栖薫, 松本昌泰. Target signをみとめトキソプラズマ脳症と悪性リンパ腫の鑑別が困難であった60歳男性例. 臨床神経学. 2016. 56. 3. 224-224
Joyeeta Bhattacharyya, Keichiro Mihara, Motoaki Ohtsubo, Shin'ichiro Yasunaga, Yoshihiro Takihara, Masaharu Hoshi, Akiro Kimura. B-Cell Lymphoma Cells Overexpressing BMI-1 Are Correlated with Drug Resistance through Enhanced Expression of Survivin and Are Effectively Eliminated by T Cells with Anti-CD38 Chimeric Receptor. BLOOD. 2010. 116. 21. 1488-1488
安永晋一郎, 三原圭一朗, 大野芳典, 大坪素秋, 津村弥来, 石川暢恒, 時元利恵, 瀧原義宏. 白血病幹細胞の活性を支持する分子基盤の解析. 広島大学原爆放射線医科学研究所年報. 2008. 49. 94-95

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Books (3)：

消化器がん化学療法の最先端
医学と薬学 2014
骨髄異形成症候群の予後: Bmi-1を中心に
血液・腫瘍科 2006
多発性骨髄腫骨髄腫細胞表面抗原解析
日本臨床 1995

Lectures and oral presentations (10)：

Efficacy and safety of obinutuzumab in Japanese patients with FL:A subgroup analysis of GALLIUM.
(2017)
Patterns of rearrangement of immunoglobulin gene stratify prognosis of the patients with DLBCL.
(2017)
Advances of CD38-directed chimeric antigen receptor-modified T cells for hematological malignancies.
(Brainstorming Meeting on CD38 & CD157 2017)
Substantial Synergy of T Cells Independently Expressing Anti-CD19- and Anti-CD38-Chimeric Antigen Receptors against Double-Hit Lymphoma Cells.
(The 8th JSH International Symposium 2017 in Miyazaki 2017)
T cells bearing anti-CD19- and/or anti-CD38-chimeric antigen receptors effectively abrogate primary double-hit lymphoma cells
(58th American Society of Hematolofy annual meeting 2016)

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Education (1)：

1992 - 1996 Hiroshima University Graduate School, Division of Medical Sciences

Professional career (1)：

Doctor of Philosophy in Medical Science (Hiroshima University)

Association Membership(s) (9)：

日本臨床検査医学会 , 日本輸血・細胞治療学会 , 血液疾患免疫療法学会 , American Society of Hematology , 日本骨髄腫学会 , 日本臨床腫瘍学会 , 日本造血細胞移植学会 , 日本血液学会 , 日本内科学会

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