Hirayama Shoshiro

Research field (1)： Cell biology

Research keywords (5)： Proteolysis , Genome wide screening , proteasome , ubiquitin , Protein quality control

Research theme for competitive and other funds (3)：

2022 - 2024 Elucidation of an ESCRT complex-dependent microautophagy/proteasome sorting mechanism
2019 - 2022 Elucidation of the nuclear export mechanism of ubiquitinated proteins
2016 - 2018 Nuclear export mechanism of misfolded proteins

Papers (15)：

Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya, et al. Senescent cells form nuclear foci that contain the 26S proteasome. Cell reports. 2023. 112880-112880
Natsuki Shinoda, Misuzu Horikoshi, Yusuke Taira, Masaya Muramoto, Shoshiro Hirayama, Shigeo Murata, Masayuki Miura. Caspase cleaves Drosophila BubR1 to modulate spindle assembly checkpoint function and lifespan of the organism. The FEBS journal. 2023
Eiichi Hashimoto, Shota Okuno, Shoshiro Hirayama, Yoshiyuki Arata, Tsuyoshi Goto, Hidetaka Kosako, Jun Hamazaki, Shigeo Murata. Enhanced O-GlcNAcylation Mediates Cytoprotection under Proteasome Impairment by Promoting Proteasome Turnover in Cancer Cells. iScience. 2020. 23. 7. 101299-101299
Yoshiyuki Arata, Ayaka Watanabe, Ryo Motosugi, Ryuichi Murakami, Tsuyoshi Goto, Shohei Hori, Shoshiro Hirayama, Jun Hamazaki, Shigeo Murata. Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence. Genes to Cells. 2019. 24. 12. 801-813
Arata Y, Watanabe A, Motosugi R, Iemura SI, Natsume T, Mukai K, Taguchi T, Hirayama S, Hamazaki J, Murata S. FAM48A mediates compensatory autophagy induced by proteasome impairment. Genes to cells. 2019. 24. 8. 559-568

ｍore...

MISC (2)：

Shoshiro Hirayama, Yuji Yamazaki, Akira Kitamura, Yukako Oda, Daisuke Morito, Katsuya Okawa, Hiroshi Kimura, Douglas M. Cyr, Hiroshi Kubota, Kazuhiro Nagata. マックジック-カウフマン病タンパク質は細胞質と中心体を素早く行き来し,その疾患原因変異体タンパク質は品質管理E3 リガーゼCHIP により素早く分解される. 第40 回日本発生生物学会・第59 回日本細胞生物学会合同大会,福岡市,2007.5.28-30. 2007
Hiroshi Kubota, Yuji Yamazaki, Akira Kitamura, Yukako Oda, Shoshiro Hirayama, Kazuhiro Nagata. Mckusich- Kaufman syndrome gene product is a chaperonin-like molecule abundan in the centrosome and degraded upon disease-causing mutation. 第58 回日本細胞生物学会大会, さいたま市, 2005. 6. 14-17. 2005

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