Rchr
J-GLOBAL ID:201801010891654506   Update date: Jul. 09, 2025

Hirayama Shoshiro

Hirayama Shoshiro
Research field  (3): Functional biochemistry ,  Molecular biology ,  Cell biology
Research keywords  (6): オートファジー ,  Proteolysis ,  Genome wide screening ,  proteasome ,  ubiquitin ,  Protein quality control
Research theme for competitive and other funds  (6):
  • 2023 - 2025 "Visualization of a novel protein quality control mechanism by the ubiquitome, including atypical translation products."
  • 2022 - 2024 Elucidation of an ESCRT complex-dependent microautophagy/proteasome sorting mechanism
  • 2019 - 2022 Elucidation of the nuclear export mechanism of ubiquitinated proteins
  • 2016 - 2018 Nuclear export mechanism of misfolded proteins
  • 2012 - 2012 UBIN-POST系によるポリユビキチン化構造異常タンパク質の核外排出メカニズム
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Papers (19):
  • Shoshiro Hirayama, Shigeo Murata. Microaggrephagy: an ESCRT-I-PTPN23-dependent pathway for MAPT/tau aggregate clearance. Autophagy. 2025
  • Yusen Men, Shoshiro Hirayama, Shinpei Ao, Yasuyuki Sakurai, Yuri Shibata, Megan Lo, Yusuke Sato, Shigeo Murata. ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates. The Journal of cell biology. 2025. 224. 6
  • Noritaka Ohigashi, Shoshiro Hirayama, Hideki Yashiroda, Shigeo Murata. Vacuolar Sts1 Degradation-Induced Cytoplasmic Proteasome Translocation Restores Cell Proliferation. Genes to cells : devoted to molecular & cellular mechanisms. 2025. 30. 2. e70004
  • Yan Wang, Yi Wang, Tomohiro Iriki, Eiichi Hashimoto, Maki Inami, Sota Hashimoto, Ayako Watanabe, Hiroshi Takano, Ryo Motosugi, Shoshiro Hirayama, et al. The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation. Nature communications. 2025. 16. 1. 1600-1600
  • Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya, et al. Senescent cells form nuclear foci that contain the 26S proteasome. Cell reports. 2023. 112880-112880
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MISC (12):
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Lectures and oral presentations  (4):
  • Spatial regulation and degradation of ubiquitinated nascent chains
    (International symposium on Multifaceted Protein Dynamics 2024)
  • The elucidation of the mechanism for the nuclear export of ubiquitinated nascent proteins and its physiological significance
    (2024)
  • ESCRT-I複合体が小胞体上のコレステロール合成酵素のプロテアソーム分解に関与することの生理的意義の解明
    (第5 回「マルチモードオートファジー」班会議 第15 回 オートファジー研究会 2023)
  • 非典型的翻訳産物を含めた新規タンパク質品質管理機構のユビキトームによる可視化
    (「マルチファセット・プロテインズー拡大し変容するタンパク質の世界」班会議 2023)
Work history (3):
  • 2025/04 - Hamamatsu University School of Medicine
  • 2012/08 - 2025/03 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2012/04 - 2012/07 日本学術振興会特別研究員(PD)
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