Kubo Tomohiro

Affiliation and department：

Research field (2)： Biophysics , Cell biology

Research keywords (7)： Polyglutamylation , Post-translational modification , Tubulin , Dynein , Chlamydomonas , Cilium , Flagellum

Research theme for competitive and other funds (10)：

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Papers (21)：

Tomohiro Kubo, Rinka Sasaki, Toshiyuki Oda. Tubulin glycylation controls ciliary motility through modulation of outer-arm dyneins. Molecular Biology of the Cell. 2024
Tomohiro Kubo, Yuma Tani, Haru-Aki Yanagisawa, Masahide Kikkawa, Toshiyuki Oda. α- and β-tubulin C-terminal tails with distinct modifications are crucial for ciliary motility and assembly. Journal of Cell Science. 2023
Tomohiro Kubo, Natsumi Kanou, Toshiyuki Oda. Puromycin is incorporated into regenerating flagella of Chlamydomonas reinhardtii as an indicator of nascent flagellar proteins. 2022
Yuqing Hou, Lei Zhao, Tomohiro Kubo, Xi Cheng, Nathan McNeill, Toshiyuki Oda, George B. Witman. Chlamydomonas FAP70 is a component of the previously uncharacterized ciliary central apparatus projection C2a. Journal of Cell Science. 2021
Julie Craft Van De Weghe, J. Aaron Harris, Tomohiro Kubo, George B. Witman, Karl F. Lechtreck. Diffusion rather than IFT likely provides most of the tubulin required for axonemal assembly. Journal of Cell Science. 2020. jcs.249805-jcs.249805

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MISC (2)：

T. Kubo, M. Hirono, T. Aikawa, G. B. Witman, R. Kamiya. A suppressor mutant, ssh1, of flagellar shortness in dynein-deficient Chlamydomonas strains is deficient in the gene encoding FAP234, a protein involved in tubulin polyglutamylation. MOLECULAR BIOLOGY OF THE CELL. 2013. 24
T. Kubo, H-A. Yanagisawa, Z. Liu, R. Shibuya, M. Hirono, R. Kamiya. A novel Chlamydomonas mutant, tpg2, reveals a conserved 177-kDa protein crucial for the localization of TTLL9, an enzyme that catalyzes tubulin polyglutamylation in the axoneme. MOLECULAR BIOLOGY OF THE CELL. 2012. 23

Lectures and oral presentations (41)：

Tubulin glycylation controls ciliary motility through modulation of outer-arm dyneins
(2024)
クラミドモナスの鞭毛内で見つかった蛋白質合成系の解明
(第13回繊毛研究会 2023)
Distinct roles of a- and b-tubulin C-terminal tails for ciliary function as revealed by a CRISPR/Cas9 mediated gene editing in Chlamydomonas
(The 49th Naito Conference 2023)
Elucidation of a protein synthesis machinery in the cilia of the unicellular green alga Chlamydomonas
(2023)
Distinct roles of a- and b-tubulin C-terminal tails for ciliary function as revealed by a CRISPR/Cas9 mediated gene editing in Chlamydomonas
(20th International Conference on the Cell and Molecular Biology of Chlamydomonas 2023)

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Education (4)：

2009 - 2012 The University of Tokyo Graduate School of Science Department of Biological Sciences, Doctoral course
2007 - 2009 The University of Tokyo Graduate School of Science Department of Biological Sciences, Master's course
2005 - 2007 The University of Tokyo Faculty of Science Department of Biological Sciences
2003 - 2005 The University of Tokyo Natural Sciences II

Professional career (1)：

Work history (7)：

2020/08 - 現在 Hosei University
2019/04 - 現在 University of Yamanashi Medical School Department of Anatomy and Structural Biology Lecturer
2016/04 - 2019/03 University of Yamanashi Medical School Department of Anatomy and Structural Biology Project Assistant Professor
2014/04 - 2016/03 University of Massachusetts Medical School Cell and Developmental Biology Postdoctoral Research Associate
2013/04 - 2014/03 University of Massachusetts Medical School Cell and Developmental Biology Postdoctoral Research Associate (Founded by Uehara Memorial Foundation)

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Awards (3)：

2023/07 - Poster Award for Excellence Distinct roles of a- and b-tubulin C-terminal tails for ciliary function as revealed by a CRISPR/Cas9 mediated gene editing in Chlamydomonas
2014/06 - 16th International Conference on the Cell and Molecular Biology of Chlamydomonas. 1st place Poster award
2012/06 - 16th International Conference on the Cell and Molecular Biology of Chlamydomonas. 3rd place Poster award

Association Membership(s) (3)：

THE BIOPHYSICAL SOCIETY OF JAPAN , THE ZOOLOGICAL SOCIETY OF JAPAN , JAPAN SOCIETY FOR CELL BIOLOGY

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