Shinjo Keiko

シンジョウケイコ | Shinjo Keiko

Affiliation and department：
Job title： Lecturer

Research field (2)： Molecular biology , Tumor biology

Research keywords (2)： Epigenetics , Cancer

Research theme for competitive and other funds (5)：

2023 - 2026 シングルセルエピゲノム解析による膵臓がん悪性化に関与する非翻訳長鎖RNAの同定
2021 - 2024 神経線維腫症1型の特性から解明するScarless Wound Healing
2019 - 2022 Dynamic regulation of cancer associated fibroblast via functional RNA as a novel therapeutic target for pancreas cancer
2019 - 2022 エピジェネティクス機構制御によるケロイド・肥厚性瘢痕に対する新規治療法の開発
2019 - 2022 EZH2過剰発現により誘導される新規異常複合体の解明

Papers (47)：

Deguchi, S., Ohka, F., Shiba, Y., Yamaguchi, J., Sato, A., Shinjo, K., Arakawa, Y., Narita, Y., Kondo, Y., Saito, R. Investigator-initiated phase I trial of an oligonucleotide therapeutic targeting long noncoding RNA TUG 1 for recurrent glioblastoma. BMC CANCER. 2025. 25. 1. 251
Shinjo, K., Umehara, T., Niwa, H., Sato, S., Katsushima, K., Sato, S., Wang, XX, Murofushi, Y., Suzuki, MM, Koyama, H., et al. Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma. CANCER GENE THERAPY. 2024. 31. 12. 1884-1894
Mayumi Oishi, Keiko Shinjo, Keisuke Takanari, Ayako Muraoka, Miho M Suzuki, Miki Kanbe, Shinichi Higuchi, Katsumi Ebisawa, Kazunobu Hashikawa, Yuzuru Kamei, et al. Exclusive expression of KANK4 promotes myofibroblast mobility in keloid tissues. Scientific reports. 2024. 14. 1. 8725-8725
Ryosuke Sonobe, Peng Yang, Miho M. Suzuki, Keiko Shinjo, Kenta Iijima, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka, Hiroaki Kajiyama, Yutaka Kondo. Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta. Cancer Science. 2024
Katsunobu Kashiwagi, Junko Yoshida, Hiroshi Kimura, Keiko Shinjo, Yutaka Kondo, Kyoji Horie. Mutation of the SWI/SNF complex component Smarce1 decreases nucleosome stability in embryonic stem cells and impairs differentiation. Journal of cell science. 2024. 137. 6

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MISC (77)：

Suehiro, Y., Shinjo, K., Kondo, Y., Takami, T., Yamasaki, T. Serum CA19-9 in combination with methylated HOXA1 and SST is useful to diagnose stage I pancreatic cancer. CANCER SCIENCE. 2024. 115. 1580-1580
Suzuki, M., Iijima, K., Shinjo, K., Kondo, Y. Regulation of genome instability by long non-coding RNA. CANCER SCIENCE. 2024. 115. 738-738
Xie, JQ, Suzuki, M., Shinjo, K., Kondo, Y. LncRNA TUG1 involved in resolution of genomic region-specific R-loop by interacting with different proteins. CANCER SCIENCE. 2024. 115. 1168-1168
Wang, XX, Shinjo, K., Kumegawa, K., Maruyama, R., Mii, S., Murofushi, Y., Suzuki, M., Enomoto, A., Kondo, Y. Exploring the Role of Transgelin in Cancer-associated Fibroblasts in the Development of Pancreatic Adenocarcinoma. CANCER SCIENCE. 2024. 115. 1698-1698
Xie, JQ, Suzuki, M., Iijima, K., Shinjo, K., Kondo, Y. Identification of long non-coding RNA and protein interactions through CRISPR-Cas13 system. CANCER SCIENCE. 2023. 114. 2080-2080

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Books (9)：

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Lectures and oral presentations (7)：

脳腫瘍を標的とした新規LSD1阻害剤の開発
(第82回日本癌学会学術総会 2023)
LSD1を標的とした脳腫瘍の新規治療薬の開発
(第27回分子標的治療学会学術集会 2023)
新規LSD1阻害剤の開発と脳腫瘍に対する治療効果
(第16回エピジェネティクス研究会年会 2023)
がんエピジェネティクスの新展開
(第81回日本癌学会学術総会 2022)
脳腫瘍を標的とした新規LSD1阻害剤の開発とその機序の解明
(第81回日本癌学会学術総会 2022)

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Work history (1)：

2017/07 - 現在 Nagoya University Graduate School of Medicine Center for Neurological Diseases and Cance Division Lecturer

Awards (3)：

2021/05 - 日本がん分子標的治療学会第25回日本がん分子標的治療学会学術集会優秀演題賞新規LSD1阻害剤の開発
2011/04 - American Association for Cancer Research 2011 AACR-GlaxoSmithKline Outstanding Clinical Scholars Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with clinical outcome of lung adenocarcinoma
2010/01 - American Association for Cancer Research AstraZeneca International Scholar-in-Training Award Significance of CpG island methylator phenotype in human lung cancers

Association Membership(s) (3)：

The Japanese Society for Epigenetics , The Japanese Association for Molecular Target Therapy of Cancer , Japanese Cancer Association

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