Rchr
J-GLOBAL ID:201801010967301039   Update date: Aug. 16, 2024

Watanabe Hirotaka

Watanabe Hirotaka
Affiliation and department:
Job title: 特任講師
Research field  (1): Neuroscience - general
Research keywords  (6): Synapse ,  iPSC ,  Genome editing ,  Animal model ,  Neurobiology ,  Alzheimer's disease
Research theme for competitive and other funds  (7):
  • 2022 - 2026 シナプス活動変容からアプローチするアルツハイマー病発症機序の解明
  • 2024 - 2026 APOEレアバリアントによるタウ病理抑制の分子機序解明
  • 2022 - 2025 ALS運動ニューロン標的iPS細胞創薬から同定された薬物のグリア細胞疾患修飾作用
  • 2023 - 2024 アルツハイマー病に係るプロテアーゼの基質同定法の開発
  • 2021 - 2023 ミクログリア機能変容に着目したアルツハイマー病モデルの開発
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Papers (42):
  • Nicolas Leventoux, Satoru Morimoto, Mitsuru Ishikawa, Shiho Nakamura, Fumiko Ozawa, Reona Kobayashi, Hirotaka Watanabe, Sopak Supakul, Satoshi Okamoto, Zhi Zhou, et al. Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes. Acta neuropathologica. 2024. 147. 1. 84-84
  • Rei Murakami, Hirotaka Watanabe, Hideko Hashimoto, Mayu Kashiwagi-Hakozaki, Tadafumi Hashimoto, Celeste M Karch, Takeshi Iwatsubo, Hideyuki Okano. Inhibitory roles of Apolipoprotein E Christchurch astrocytes in curbing tau propagation using human pluripotent stem cell-derived models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024
  • Hirotaka Watanabe, Rei Murakami, Kazuya Tsumagari, Satoru Morimoto, Tadafumi Hashimoto, Kent Imaizumi, Iki Sonn, Kaoru Yamada, Yuko Saito, Shigeo Murayama, et al. Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model. Stem Cell Reports. 2023
  • Sho Yoshimatsu, Fumiko Seki, Junko Okahara, Hirotaka Watanabe, Hiroki Sasaguri, Yawara Haga, Jun-ichi Hata, Tsukasa Sanosaka, Takashi Inoue, Takayuki Mineshige, et al. Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter. Neuroscience Research. 2022
  • Iki Sonn, Fumiko Honda-Ozaki, Sho Yoshimatsu, Satoru Morimoto, Hirotaka Watanabe, Hideyuki Okano. Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia. Inflammation and regeneration. 2022. 42. 1. 20-20
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MISC (4):
Lectures and oral presentations  (9):
  • ヒトiPS細胞由来ミクログリアを用いた認知症研究の新展開
    (第42回日本認知症学会学術集会 2023)
  • ヒトグリア細胞を用いた神経変性疾患研究
    (第41回日本認知症学会学術集会/第37回日本老年精神医学会[合同開催] 2022)
  • Development of novel stem cell tool to examine physiological functions of presenilin/γ-secretase in human neurons
    (NEURO2019 2019)
  • Presenilin and Alzheimer’s.
    (Blue Ribbon Panel Meeting 2018)
  • The roles of γ-secretase and its substrates on the pathogenesis of neurodegenerative dementia.
    (National Institute of Genetics- the 1801st Biological Symposium 2015)
more...
Professional career (1):
  • 医学博士 (東京大学)
Work history (4):
  • 2015/05 - 現在 Keio University School of Medicine Department of Physiology Project Assistant Professor
  • 2006/11 - 2015/04 Brigham and Women's Hospital Department of Neurology Instructor
  • 2002/04 - 2006/10 The University of Tokyo The Institute of Medical Science Division of Host-Parasite Interaction
  • 1996/04 - 2002/03 JAPAN TOBACCO INC. Pharmaceutical Frontier Institute
Association Membership(s) (3):
Japan Society for Dementia Research ,  Society for Neuroscience ,  Japan Neuroscience Society
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