Rchr
J-GLOBAL ID：201801011028733763
Update date: Jul. 08, 2024
Maruhashi Takumi
マルハシ タクミ | Maruhashi Takumi
Affiliation and department：
Job title：
助教
Research field (1)：
Immunology
Research theme for competitive and other funds (5)：
- 2024 - 2027 ペプチド-MHCII複合体の構造多様性の生物学的意義の解明
- 2023 - 2025 LAG-3によるself-pMHCII認識を起点とした恒常性維持機構の解明
- 2021 - 2024 LAG-3の抑制機能作動原理および制御機構の解明
- 2019 - 2021 Regulatory mechanisms of anti-tumor immunity by inhibitory coreceptor, LAG-3
- 2011 - 2012 骨免疫疾患における樹状細胞受容体Dcirの機能解明
Papers (23)：
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Tomonori Kaifu, Takumi Maruhashi, Soo-Hyun Chung, Kenji Shimizu, Akira Nakamura, Yoichiro Iwakura. DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling. Frontiers in immunology. 2023. 14. 1159058-1159058
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Takumi Maruhashi, Daisuke Sugiura, Il-Mi Okazaki, Kenji Shimizu, Takeo K Maeda, Jun Ikubo, Harunori Yoshikawa, Katsumi Maenaka, Naozumi Ishimaru, Hidetaka Kosako, et al. Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity. Immunity. 2022. 55. 5. 912-924
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Daisuke Sugiura, Il-Mi Okazaki, Takeo K Maeda, Takumi Maruhashi, Kenji Shimizu, Rieko Arakaki, Tatsuya Takemoto, Naozumi Ishimaru, Taku Okazaki. PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity. Nature immunology. 2022. 23. 3. 399-410
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Yulia Makusheva, Soo-Hyun Chung, Aoi Akitsu, Natsumi Maeda, Takumi Maruhashi, Xiao-Qi Ye, Tomonori Kaifu, Shinobu Saijo, Haiyang Sun, Wei Han, et al. The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17. Experimental animals. 2022
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Tomonori Kaifu, Rikio Yabe, Takumi Maruhashi, Soo-Hyun Chung, Hiroaki Tateno, Noriyuki Fujikado, Jun Hirabayashi, Yoichiro Iwakura. DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis. The Journal of experimental medicine. 2021. 218. 12
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Books (7)：
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LAG-3による自己免疫とがん免疫の抑制機構
感染・炎症・免疫 53(1): 19-30 2023
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免疫チェックポイント阻害剤の作用メカニズム
実験医学増刊 40(20): 3340-3345 2022
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LAG-3は安定な構造を持つpMHCIIと結合することでT細胞の機能を制御して自己免疫応答とがん免疫応答を抑制する
日本免疫学会ニュースレター 31(1):8 2022
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第3の免疫チェックポイント分子LAG-3によるヘルパーT細胞応答の選択的な抑制機構
医学のあゆみ 270(6,7):567-568 2019
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免疫チェックポイント分子LAG-3によるTh細胞応答の選択的な抑制機構
日本免疫学会ニュースレター 27(2):14 2019
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Education (3)：
- 2010 - 2013 The University of Tokyo Graduate School of Science
- 2008 - 2010 Tokyo Institute of Technology
- 2004 - 2008 Tokyo Institute of Technology
Professional career (1)：
Work history (4)：
- 2019/12 - 現在 The University of Tokyo Institute for Quantitative Biosciences Assistant Professor
- 2013/09 - 2019/11 Tokushima University Institute of Advanced Medical Sciences Designated Assistant Professor
- 2013/04 - 2013/08 Tokyo University of Science Research Institute for Biomedical Sciences Postdoctoral fellow
- 2011/04 - 2013/03 日本学術振興会特別研究員(DC2)
Awards (7)：
Association Membership(s) (1)：
THE JAPANESE SOCIETY FOR IMMUNOLOGY
