Rchr
J-GLOBAL ID:201801011133077626   Update date: May. 12, 2021

SAKAI Juro

サカイ ジュロウ | SAKAI Juro
Affiliation and department:
Job title: 教授
Homepage URL  (1): http://www.mm.rcast.u-tokyo.ac.jp/
Research field  (2): Clinical pharmacy ,  Physiology
Research theme for competitive and other funds  (24):
  • 2020 - 2026 生活習慣病予防に働く早期ライフステージの生活環境記憶の解明
  • 2020 - 2022 栄養-代謝-エピゲノム軸による細胞機能調節の仕組みを解明
  • 2020 - 2022 代謝入力による脂肪細胞の遺伝子発現機構の解明
  • 2016 - 2021 Elucidation of lifestyle-related diseases development due to environmental factors and epigenetic memory
  • 2018 - 2020 熱産生脂肪細胞を誘導するエピゲノム酵素リン酸化スイッチの解明
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Papers (98):
  • Ji Zhang, Yoshihiro Matsumura, Yuka Kano, Ayano Yoshida, Takeshi Kawamura, Hiroyuki Hirakawa, Takeshi Inagaki, Toshiya Tanaka, Hiroshi Kimura, Shigeru Yanagi, et al. Ubiquitination dependent and independent repression of target genes by SETDB1 reveals a context dependent role for its methyltransferase activity during adipogenesis. Genes to Cells. 2021
  • Takeshi Yoneshiro, Naoya Kataoka, Jacquelyn M Walejko, Kenji Ikeda, Zachary Brown, Momoko Yoneshiro, Scott B Crown, Tsuyoshi Osawa, Juro Sakai, Robert W McGarrah, et al. Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. eLife. 2021. 10
  • Muramatsu M, Osawa T, Miyamura Y, Nakagawa S, Tanaka T, Kodama T, Aburatani H, Sakai J, Ryeom S, Minami T. Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background. J Biol Chem. 2021. 100697
  • Akira Shiono, Hiroki Sasaki, Reio Sekine, Yohei Abe, Yoshihiro Matsumura, Takeshi Inagaki, Toshiya Tanaka, Tatsuhiko Kodama, Hiroyuki Aburatani, Juro Sakai, et al. PPARα activation directly upregulates thrombomodulin in the diabetic retina. Scientific reports. 2020. 10. 1. 10837-10837
  • Yusuke Sasaki, Masato Asahiyama, Toshiya Tanaka, Shogo Yamamoto, Kentaro Murakami, Wakana Kamiya, Yoshihiro Matsumura, Tsuyoshi Osawa, Motonobu Anai, Jean-Charles Fruchart, et al. Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content. Scientific reports. 2020. 10. 1. 7818-7818
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MISC (67):
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Lectures and oral presentations  (31):
  • 肥満発症に関与するエピゲノム酵素のシグナル感知とヒストン脱メチル化機構の解明
    (第41回日本肥満学会 2021)
  • Histone demethylase JMJD1A mediates adaptive thermogenesis via two independent mechanisms and in two different type of adipose tissue under cold environment
    (2020)
  • 脂肪細胞分化を制御するヒストンメチル化・脱メチル化反応
    (第93回 日本生化学会大会 2020)
  • SETDB1 represses H3K4/H3K9me3 bivalent genes by ubiquitination-dependent and -independent mechanisms.
    (2020)
  • SETDB1 represses H3K4/H3K9me3 bivalent genes by ubiquitination-dependent and -independent mechanisms.
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Education (2):
  • 1990 - 1994 東北大学大学院
  • 1982 - 1988 Tohoku University
Professional career (1):
  • 博士(医学) (東北大学)
Work history (7):
  • 2020/04 - 現在 東北大学 大学院医学系研究科 細胞生物学講座 分子代謝生理学分野 (分野名改称) 教授
  • 2009/07 - 現在 The University of Tokyo Research Center for Advanced Science and Technology
  • 2017/04 - 2020/03 Tohoku University Graduate School of Medicine
  • 2003/01 - 2009/06 The University of Tokyo Research Center for Advanced Science and Technology
  • 2001/12 - 2006/03 科学技術振興事業団 創造科学技術推進事業 柳沢オーファン受容体プロジェクト グループリーダー
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Awards (3):
  • 2011/07 - 日本動脈硬化学会 第6回 五島雄一郎賞
  • 2008/10 - 財団法人 病態代謝研究会 第39回最優秀理事長賞
  • 2001 - 財団法人成人血管病研究振興財団 岡本研究奨励賞
Association Membership(s) (11):
日本心血管内分泌学会 ,  日本臨床分子医学会 ,  日本血管生物医学会 ,  日本高血圧学会 ,  The Japan Endocrine Society ,  THE JAPAN DIABETES SOCIETY ,  JAPAN SOCIETY FOR THE STUDY OF OBESITY ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  JAPAN ATHEROSCLEROSIS SOCIETY
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