HARADA KANA

ハラダカナ | HARADA KANA

Affiliation and department：
Job title：助教

Research field (1)： Pharmacology

Research keywords (5)： serotonin transporter , polyphosphate , macrophage , bone , microglia

Research theme for competitive and other funds (8)：

2022 - 2025 パルミトイル化によるセロトニントランスポーター制御とうつ病の関連、創薬への可能性
2019 - 2021 Identification of novel ER stress relieving drugs using a high-content microscope and application to therapeutic development
2019 - 2021 Regulation of inflammation-associated cytokines by inorganic polyphosphate for the treatment of peri-implantitis
2016 - 2019 Identification and application of novel chaperone mechanism using C-terminal deficient serotonin transporter as a sensor
2016 - 2019 Screening and application of drugs that facilitate membrane trafficking in order to overcome ER stress-related diseases

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Papers (24)：

Tomomi Ishi, Taketoshi Kajimoto, Soshi Narasaki, Soma Noguchi, Serika Imamura, Kana Harada, Izumi Hide, Shigeru Tanaka, Yasuo M Tsutsumi, Norio Sakai. PKC in a light-dependent manner at high concentrations via the production of singlet oxygen. European Journal of Pharmacology. 2024. 984. 177036-177036
Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, et al. Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells. Frontiers in pharmacology. 2023. 14. 1284586-1284586
Soshi Narasaki, Soma Noguchi, Tomoaki Urabe, Kana Harada, Izumi Hide, Shigeru Tanaka, Yuhki Yanase, Taketoshi Kajimoto, Kazue Uchida, Yasuo M Tsutsumi, et al. Identification of protein kinase C domains involved in its translocation induced by propofol. European journal of pharmacology. 2023. 955. 175806-175806
Izumi Hide, Hiroko Shiraki, Akihiro Masuda, Takuya Maeda, Mayuka Kumagai, Nao Kunishige, Yuhki Yanase, Kana Harada, Shigeru Tanaka, Norio Sakai. P2Y2 receptor mediates dying cell removal via inflammatory activated microglia. Journal of pharmacological sciences. 2023. 153. 1. 55-67
Kana Harada, Ryoma Sho, Hiromiki Takakura, Eri Yokoyama, Reika Koyama, Yuka Yamamoto, Naoko Adachi, Shigeru Tanaka, Izumi Hide, Norio Sakai. S-Palmitoylation of the serotonin transporter promotes its cell surface expression and serotonin uptake. Biochemical and Biophysical Research Communications. 2023. 662. 58-65

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MISC (77)：

NOGUCHI Soma, KAJIMOTO Taketoshi, URABE Tomoaki, NARASAKI Soshi, NARASAKI Soshi, HARADA Kana, TANAKA Shigeru, HIDE Izumi, SAKAI Norio. Spatiotemporal analysis of propofol-induced PKC translocation. 日本神経化学会大会抄録集(Web). 2023. 66th
SAKAI Norio, HIRAKAWA Haruki, TAGUCHI Kei, MURAKAWA Seiya, ASANO Masaya, NOGUCHI Soma, KIKKAWA Satoru, HARADA Kana, HIDE Izumi, TANAKA Shigeru. The nonsteroidal anti-inflammatory drug flurbiprofen regulates serotonin transporter function. 日本神経化学会大会抄録集(Web). 2023. 66th
野口颯真, 梶本武利, 楢崎壮志, 楢崎壮志, 卜部智晶, 石井友美, 石井友美, 原田佳奈, 田中茂, 秀和泉, et al. 静脈麻酔薬Propofolによる核内外のタンパク質の局在の変化. 日本薬理学雑誌. 2023. 158. Supplement
酒井規雄, 新開匡, 野口颯真, 楢崎壮志, 楢崎壮志, 石井友美, 石井友美, 原田佳奈, 秀和泉, 田中茂. 静脈麻酔薬Propofolが誘発するPKC分子種特異的トランスロケーション-PKCηの場合. 日本薬理学雑誌. 2023. 158. Supplement
原田佳奈, 山本有華, 香山怜佳, 横山英里, 高倉大幹, 庄亮真, 足立直子, 田中茂, 秀和泉, 酒井規雄. セロトニントランスポーターのパルミトイル化部位の解析. 日本薬理学雑誌. 2023. 158. Supplement

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Lectures and oral presentations (92)：

プロテインキナーゼC(PKC) 阻害剤カルホスチンCは、一重項酸素の産生を介して、高濃度で光依存的にPKCを活性化する。
(NEURO2024 第47回日本神経科学大会第67回日本神経化学会大会第46回日本生物学的精神医学会年会第8回アジアオセアニア神経科学連合コングレス 2024)
神経細胞刺激後急速に発現するGPR3転写調節メカニズムと関連遺伝子に与える影響
(第145回日本薬理学会近畿部会 2024)
プロポフォールによる小胞体の形態変化と細胞内カルシウム動態
(第144回日本薬理学会近畿部会 2024)
Intracellular calcium dynamics induced by Propofol and Nicotine - Observations using the intracellular organelle calcium indicator CEPIA (calcium-measuring organelle-entrapped protein indicators)
(2023)
Regulatory mechanism of immediate early G protein-coupled receptor 3 gene expression during neuronal differentiation in PC12 cells
(2023)

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Education (4)：

2007 - 2011 Hiroshima University Graduate School of Biomedical Sciences Graduate School of Biomedical Sciences
2007 - 2007 Hiroshima University Graduate School of Biomedical Sciences Graduate School of Biomedical Sciences
2005 - 2007 Hiroshima University Graduate School of Biomedical Sciences Graduate School of Biomedical Sciences
2001 - 2005 Hiroshima University Faculty of Medicine

Professional career (1)：

Ph.D. (Hiroshima University)

Work history (5)：

2019/04/01 - Hiroshima University Graduate School of Biomedical & Health Sciences Assistant Professor
2018/04/01 - 2019/03/31 Hiroshima University Graduate School of Biomedical & Health Sciences Assistant Professor
2014/04 - 2018/03 Hiroshima International University Faculty of Pharmaceutical Sciences Assistant Professor (Special Appointment)
2013/03/01 - 2014/03/31 Hiroshima University Graduate School of Biomedical & Health Sciences Researcher
2011/04/01 - 2013/02/28 Hiroshima University Graduate School of Biomedical & Health Sciences Assistant Professor (Special Appointment)

Committee career (1)：

2024/04 - 現在公益社団法人日本薬理学会学術評議員

Awards (1)：

2014/08/09 - Young Investigators Award

Association Membership(s) (3)：

The Pharmaceutical Society of Japan , The Japanese Society for Neurochemistry , The Japanese Pharmacological Society

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