HARADA KANA

ハラダカナ | HARADA KANA

Affiliation and department：
Job title：助教

Research field (1)： Pharmacology

Research keywords (5)： serotonin transporter , polyphosphate , macrophage , bone , microglia

Research theme for competitive and other funds (7)：

2022 - 2025 パルミトイル化によるセロトニントランスポーター制御とうつ病の関連、創薬への可能性
2019 - 2021 Identification of novel ER stress relieving drugs using a high-content microscope and application to therapeutic development
2019 - 2021 Regulation of inflammation-associated cytokines by inorganic polyphosphate for the treatment of peri-implantitis
2016 - 2018 Functional switch of inflammatory macrophages and novel treatment strategies for peri-implantitis
2014 - 2015 Effects of polyphosphate on inflammatory bone resorption: Development of novel treatment strategies for peri-implantitis

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Papers (18)：

Masuda, Shun, Tanaka, Shigeru, Shiraki, Hiroko, Sotomaru, Yusuke, Harada, Kana, Hide, Izumi, Kiuchi, Yoshiaki, Sakai, Norio. GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice. NEUROBIOLOGY OF DISEASE. 2022. 172. 105811
Hiroko Shiraki, Shigeru Tanaka, Yun Guo, Kana Harada, Izumi Hide, Tomoharu Yasuda, Norio Sakai. Potential role of inducible GPR3 expression under stimulated T cell conditions. Journal of Pharmacological Sciences. 2022. in press
Haruki Hirakawa, Kei Taguchi, Seiya Murakawa, Masaya Asano, Sohma Noguchi, Satoshi Kikkawa, Kana Harada, Naoko Adachi, Takehiko Ueyama, Izumi Hide, Shigeru Tanaka, Norio Sakai. Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant. Journal of Pharmacological Sciences. 2022. 148. 187-195
Shigeru Tanaka, Naoto Shimada, Hiroko Shiraki, Tatsuhiro Miyagi, Kana Harada, Izumi Hide, Norio Sakai. GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons. Molecular and Cellular Neuroscience. 2021. 118. 103691
Serika Motoike, Kei Taguchi, Kana Harada, Masaya Asano, Izumi Hide, Shigeru Tanaka, Masahiro Irifune, Norio Sakai. Syntaxin 3 interacts with serotonin transporter and regulates its function. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2021. 145. 4. 297-307

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MISC (6)：

片桐匡弥, 飯田幸治, 石原熊寿, 原田佳奈, 香川幸太, 瀬山剛, 岡村朗健, 橋詰顕, 庫本高志, 花谷亮典, et al. 遺伝性てんかんモデルラットにおける迷走神経刺激による急性および慢性発作減少効果に関するメカニズム(The Mechanism of Acute and Chronic Anti-seizure Effect of Vagus Nerve Stimulation in The Genetic-epileptic Model Rat). てんかん研究. 2019. 37. 2. 532-532
Mayumi Kamigaki, Izumi Hide, Yuhki Yanase, Kana Harada, Takahiro Seki, Shigeru Tanaka, Michihiro Hide, Norio Sakai. Drastic expression of granulocyte macrophage colony-stimulating factor (GM-CSF) by Toll-like receptor 4-activated surviving microglia. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 216P-216P
Izumi Hide, Kana Harada, Takahiro Seki, Shigeru Tanaka, Yuhki Yanase, Norio Sakai. Distinct cellular responses to Toll-like receptor 4 activation in microglia: modulation via purinergic receptors. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 228P-228P
Shunsuke Fujiwara, Izumi Hide, Kana Harada, Shigeru Tanaka, Takahiro Seki, Norio Sakai. Involvement of P2X(7) receptors in TNF release from Toll-like receptor 4-activated microglia: regulation by acidic pH. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2011. 115. 136P-136P
Kana Harada, Izumi Hide, Shunsuke Fujiwara, Takahiro Seki, Shigeru Tanaka, Yoshihiro Nakata, Norio Sakai. Death or survival of Toll-like receptor 4-activated microglia is regulated by extracellular ATP. NEUROSCIENCE RESEARCH. 2010. 68. E238-E239

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Lectures and oral presentations (79)：

OpTER: a low-cost method for measuring the transepithelial/endothelial electrical resistance TER of cell layers, which reduces research costs and the burden on us all
(JPW2022 (Japan Basic and Clinical Pharmacology Week 2022), The 96th Annual Meeting of the Japanese Pharmacological Society, The 43rd Annual Scientific Meeting of the Japanese Society of Clinical Pharmacology and Therapeutics 2022)
静脈麻酔薬 Propofol が誘発する PKC 分子種特異的トランスロケーション -PKCηの場合
(第142回日本薬理学会近畿部会 2022)
静脈麻酔薬 Propofol による核内外のタンパク質の局在の変化
(第142回日本薬理学会近畿部会 2022)
セロトニントランスポーターのパルミトイル化部位の解析
(第142回日本薬理学会近畿部会 2022)
OpTER: a Low-Cost, Reproducible and Customizable Method to Assess the Cellular Barrier Function
(NEURO2022, The 45th Annual Meeting of the Japan Neuroscience Society, The 65th Annual Meeting of the Japanese Society for Neurochemistry, The 32nd Annual Conference of the Japanese Neural Network Society 2022)

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Education (4)：

2007 - 2011 Hiroshima University Graduate School of Biomedical Sciences Graduate School of Biomedical Sciences
2007 - 2007 Hiroshima University Graduate School of Biomedical Sciences Graduate School of Biomedical Sciences
2005 - 2007 Hiroshima University Graduate School of Biomedical Sciences Graduate School of Biomedical Sciences
2001 - 2005 Hiroshima University Faculty of Medicine

Professional career (1)：

Ph.D. (Hiroshima University)

Work history (5)：

2019/04/01 - Hiroshima University Graduate School of Biomedical & Health Sciences Assistant Professor
2018/04/01 - 2019/03/31 Hiroshima University Graduate School of Biomedical & Health Sciences Assistant Professor
2014/04 - 2018/03 Hiroshima International University Faculty of Pharmaceutical Sciences Assistant Professor (Special Appointment)
2013/03/01 - 2014/03/31 Hiroshima University Graduate School of Biomedical & Health Sciences Researcher
2011/04/01 - 2013/02/28 Hiroshima University Graduate School of Biomedical & Health Sciences Assistant Professor (Special Appointment)

Awards (1)：

2014/08/09 - Young Investigators Award

Association Membership(s) (3)：

The Pharmaceutical Society of Japan , The Japanese Society for Neurochemistry , The Japanese Pharmacological Society

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