Rchr
J-GLOBAL ID:201801011441079311
Update date: Mar. 21, 2025
KOJI SAITO
サイトウ コウジ | KOJI SAITO
Affiliation and department:
Job title:
Lecturer/Junior Associate Professor
Homepage URL (1):
https://www.med.kitasato-u.ac.jp/lab/sakagami/index.php
Research field (2):
Cell biology
, Molecular biology
Research keywords (5):
Kidney podocyte
, Cell biology
, Cell cytoskeleton
, Cell polarity
, Cell migration
Research theme for competitive and other funds (13):
- 2022 - 2026 腎糸球体上皮細胞の突起形成におけるRacの活性制御機構の解明
- 2023 - 2024 腎糸球体細胞におけるプロレニンの役割解明
- 2022 - 2024 癌細胞および正常細胞におけるホスファチジルイノシトールによるFilGAPの機能制御機構の解析
- 2021 - 2022 糸球体上皮細胞突起形成に関わる細胞膜脂質の特定とその機能解析
- 2018 - 2021 Actin cytoskeletal regulation of process formation in kidney podocytes.
- 2017 - 2020 Functional analysis of FilGAP in epithelial tubulogenesisi
- 2013 - 2014 癌細胞の3次元空間におけるアメーバ様遊走の極性形成機構解析
- 2010 - 2014 Functional analysis of RacGAP FilGAP in tumor invasion and metastasis
- 2010 - 2012 細胞運動に関わる Rac1 の不活化因子 FilGAP の癌の浸潤、転移における役割.
- 2010 - 2012 Studies on the role of FiliGAP (RacGAP) in mesenchymal and amoeboid cell migration.
- 2007 - 2008 細胞膜リン脂質の膜配向性変化による細胞極性形成の空間的制御機構
- 2005 - 2006 リン脂質の膜配向性制御とアクチン細胞骨格系制御機構に関する研究
- 2006 - 細胞極性成長とリン脂質の膜非対称性の制御
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Papers (26):
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Hiroyuki Sakagami, Tomoko Shiroshima, Noriko Nemoto, Tomoko Niimura, Takeyuki Sugawara, Yoshinobu Hara, Koji Saito, Tadashi Okubo, Masahiro Fukaya. Disruption of Iqsec1 in mice leads to embryonic lethality with reduced large apical vacuoles in the visceral endoderm. FEBS Letters. 2024
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Koji Saito, Seiji Yokawa, Hidetake Kurihara, Eishin Yaoita, Sari Mizuta, Kanae Tada, Moemi Oda, Hiroyasu Hatakeyama, Yasutaka Ohta. FilGAP controls cell-extracellular matrix adhesion and process formation of kidney podocytes. The FASEB Journal. 2024. 38. 5
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Koji Saito, Sakino Ozawa, Yosuke Chiba, Ruri Takahashi, Ryoya Ogomori, Kojiro Mukai, Tomohiko Taguchi, Hiroyasu Hatakeyama, Yasutaka Ohta. FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells. Cell structure and function. 2023. 48. 2. 161-174
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Mamiko Mori, Koji Saito, Ayano Sekine, Rio Hasebe, Yasutaka Ohta. Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells. Anticancer research. 2022. 42. 12. 5763-5771
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Koji Saito, Mamiko Mori, Norito Kambara, Yasutaka Ohta. FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021. 35. 4. e21508
more...
MISC (4):
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Satoko Kanzaki, Shiori Tamura, Toshiaki Ito, Mizuki Wakabayashi, Koji Saito, Shigeki Kato, Yasutaka Ohta, Yoichi Sekita, Tohru Kimura. Involvement of Nlrp9a/b/c in mouse preimplantation development. Reproduction. 2020. 160. 2. 181-191
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Lukasz Kozubowski, Koji Saito, Jayme M. Johnson, Audrey S. Howell, Daniel J. Lew. Response: GEF localization, not just activation, is needed for yeast polarity establishment. CURRENT BIOLOGY. 2009. 19. 5. R195-R195
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Nobumichi Furuta, Konomi Fuiimura-Kamada, Takaharu Yamamoto, Koji Saito, Kazuma Tanaka. The Cdc50p family is required for recycling via early endosome in Saccharomyces cerevisiae. CELL STRUCTURE AND FUNCTION. 2005. 30. 70-70
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K Saito, K Fujimura-Kamada, N Furuta, U Kato, M Umeda, K Tanaka. Cdc50p, a protein required for polarized growth, is a potential subunit of the Drs2p aminophospholipid translocase in Saccharomyces cerevisiae. MOLECULAR BIOLOGY OF THE CELL. 2004. 15. 319A-320A
Lectures and oral presentations (52):
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腎ポドサイトにおけるsmall GTPase の活性制御分子の機能解析
(生体運動研究合同班会議 2025)
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FilGAP, a GAP protein for Rac1, controls invadopodia formation in breast cancer cells
(2023)
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Racの不活化因子FilGAPは乳がん細胞の浸潤突起形成を抑制する
(日本細胞生物学会大会 2023)
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FilGAP, a GAP for Rac, controls invadopodium formation in breast carcinoma cells
(2022)
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FilGAP, a GAP for Rac1, regulates cell-ECM adhesion and process formation of kidney podocytes
(2022)
more...
Education (3):
- 2002 - 2006 Hokkaido University Graduate School, Division of Medicine 癌医学専攻
- 1998 - 2000 Hokkaido University
- 1994 - 1998 Hokkaido University School of Fisheries Sciences
Professional career (1):
Work history (7):
Awards (1):
- 2018/03 - ポドサイト研究会 優秀演題賞 ポドサイトの突起形成におけるRacGAP因子FilGAPの役割
Association Membership(s) (4):
THE JAPANESE BIOCHEMICAL SOCIETY
, JAPAN SOCIETY FOR CELL BIOLOGY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE AMERICAN SOCIETY FOR CELL BIOLOGY
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