KOJI SAITO

サイトウコウジ | KOJI SAITO

Affiliation and department：
Job title： Lecturer/Junior Associate Professor
Homepage URL (1)： https://www.med.kitasato-u.ac.jp/lab/sakagami/index.php

Research field (2)： Cell biology , Molecular biology

Research keywords (5)： Kidney podocyte , Cell biology , Cell cytoskeleton , Cell polarity , Cell migration

Research theme for competitive and other funds (13)：

2022 - 2026 腎糸球体上皮細胞の突起形成におけるRacの活性制御機構の解明
2023 - 2024 腎糸球体細胞におけるプロレニンの役割解明
2022 - 2024 癌細胞および正常細胞におけるホスファチジルイノシトールによるFilGAPの機能制御機構の解析
2021 - 2022 糸球体上皮細胞突起形成に関わる細胞膜脂質の特定とその機能解析
2018 - 2021 Actin cytoskeletal regulation of process formation in kidney podocytes.

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Papers (26)：

Hiroyuki Sakagami, Tomoko Shiroshima, Noriko Nemoto, Tomoko Niimura, Takeyuki Sugawara, Yoshinobu Hara, Koji Saito, Tadashi Okubo, Masahiro Fukaya. Disruption of Iqsec1 in mice leads to embryonic lethality with reduced large apical vacuoles in the visceral endoderm. FEBS Letters. 2024
Koji Saito, Seiji Yokawa, Hidetake Kurihara, Eishin Yaoita, Sari Mizuta, Kanae Tada, Moemi Oda, Hiroyasu Hatakeyama, Yasutaka Ohta. FilGAP controls cell-extracellular matrix adhesion and process formation of kidney podocytes. The FASEB Journal. 2024. 38. 5
Koji Saito, Sakino Ozawa, Yosuke Chiba, Ruri Takahashi, Ryoya Ogomori, Kojiro Mukai, Tomohiko Taguchi, Hiroyasu Hatakeyama, Yasutaka Ohta. FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells. Cell structure and function. 2023. 48. 2. 161-174
Mamiko Mori, Koji Saito, Ayano Sekine, Rio Hasebe, Yasutaka Ohta. Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells. Anticancer research. 2022. 42. 12. 5763-5771
Koji Saito, Mamiko Mori, Norito Kambara, Yasutaka Ohta. FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021. 35. 4. e21508

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MISC (4)：

Lectures and oral presentations (52)：

腎ポドサイトにおけるsmall GTPase の活性制御分子の機能解析
(生体運動研究合同班会議 2025)
FilGAP, a GAP protein for Rac1, controls invadopodia formation in breast cancer cells
(2023)
Racの不活化因子FilGAPは乳がん細胞の浸潤突起形成を抑制する
(日本細胞生物学会大会 2023)
FilGAP, a GAP for Rac, controls invadopodium formation in breast carcinoma cells
(2022)
FilGAP, a GAP for Rac1, regulates cell-ECM adhesion and process formation of kidney podocytes
(2022)

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Education (3)：

Professional career (1)：

Work history (7)：

2024/08 - 現在 Kitasato University School of Medicine
2019/04 - 現在 Kitasato University School of Science, Department of Biosciences
2009/04 - 2019/03 Kitasato University School of Science, Department of Biosciences
2007/10/01 - 2009/03/31 Duke大学 Medical Center 薬理学および腫瘍生物学分野・博士研究員
2007/04 - 2007/09 Hokkaido University Institute for Genetic Medicine

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Awards (1)：

Association Membership(s) (4)：

THE JAPANESE BIOCHEMICAL SOCIETY , JAPAN SOCIETY FOR CELL BIOLOGY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE AMERICAN SOCIETY FOR CELL BIOLOGY

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