YUICHIRO NAKATA

Affiliation and department：

Research field (1)： Cell biology

Research keywords (12)： Epigenetics , Cancer , シグナル伝達 , 細胞分化 , 転写制御 , Histone modification , 老化 , オンコヒストン , 心臓マクロファージ , ポリコーム蛋白複合体 , Genetically modified mouse , Stem cell

Research theme for competitive and other funds (21)：

2023 - 2024 エピジェネティック因子PTIPによる間接的DNA損傷修復機構の解明
2022 - 2023 エピジェネティック因子による間接的DNA損傷修復機構の解明
2021 - 2022 エピジェネティック因子による間接的DNA損傷修復機構の解明
2019 - 2022 Functional analyses of enzymatic activity- and complex formation-dependent roles of UTX in the regulation of hematopoietic stem cells and development of hematopoietic diseases
2018 - 2020 ヒストン脱メチル化酵素JMJD3が持つ幹細胞性の維持と腫瘍化の二面性の解明

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Papers (15)：

Caeiro L, Nakata Y, Borges RL, Garcia-Martinez L, Banuelos C, Stransky S, Chan HL, Brabson J, Dominguez D, Zhang Y, et al. Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma. Genes Dev. 2024. accepted
Gloria Mas, Na Man, Yuichiro Nakata, Concepcion Martinez-Caja, Daniel L Karl, Felipe Beckedorff, Francesco Tamiro, Chuan Chen, Stephanie Duffort, Hidehiro Itonaga, et al. The SWI/SNF chromatin remodeling subunit DPF2 facilitates NRF2-dependent anti-inflammatory and anti-oxidant gene expression. J Clin Invest. 2023. 133. 13. e158419
神沼修, 三浦健人, 山崎憲政, 尾形佐和子, 三浦舟華, 細見直永, 中田雄一郎, 後藤穣. 制御性T細胞におけるニコチン性アセチルコリン受容体の発現と機能. 日本職業・環境アレルギー学会雑誌. 2023. 30. 1. 76-76
Garcia-Martinez L, Adams AM, Chan HL, Nakata Y, Weich N, Stransky S, Zhang Z, Alshalalfa M, Sarria L, Mahal BA, et al. Endocrine resistance and breast cancer plasticity are controlled by CoREST. Nat Struct Mol Biol. 2022. 29. 11. 1122-1135
Kobatake K, Ikeda K, Nakata Y, Yamasaki N, Kanai A, Sekino Y, Takemoto K, Fukushima T, Babasaki T, Kitano H, et al. DDX41 expression is associated with tumor necrosis in clear cell renal cell carcinoma and in cooperation with VHL loss leads to worse prognosis. Urol Oncol. 2022. 40. 10. 456.e9-456.e18

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MISC (5)：

中田雄一郎, 上田健, 金井昭教, 世良康如, 竹田浩之, 神沼修, 本田浩章. ヒストン脱メチル化酵素JMJD3が白血病を誘導させるエピゲノム制御および蛋白質相互作用の解明. 日本生化学会大会(Web). 2019. 92nd
Yuichiro Nakata, Norimasa Yamasaki, Takeshi Ueda, Kenichiro Ikeda, Akiko Nagamachi, Toshiya Inaba, Hiroaki Honda. JMJD3 Plays Essential Roles in the Maintenance of Hematopoietic Stem Cells and Leukemic Stem Cells through the Regulation of p16(INK4a). BLOOD. 2016. 128. 22
上田健, 中田雄一郎, 長町安希子, 山崎憲政, 金井昭教, 松井啓隆, 稲葉俊哉, 本田浩章. EED変異体によるPRC2活性化障害の造血器腫瘍発症における役割. 日本生化学会大会(Web). 2016. 89th. ROMBUNNO.1P-259 (WEB ONLY)-259]
Yuichiro Nakata, Takeshi Ueda, Akiko Nagamachi, Linda Wolff, Ogawa Seishi, Toshiya Inaba, Hiroaki Honda. Generation and Analysis of a Novel Mouse Model for Chronic Myelomonocytic Leukemia (CMML) with Acquired Expression of c-CBLQ367P. BLOOD. 2014. 124. 21
長町安希子, 上田健, 山崎憲政, 中田雄一郎, 海老原康広, 辻浩一郎, 田久保圭誉, 須田年生, 稲葉俊哉, 本田浩章. NF-κBに対するユビキチン修飾酵素A20はアポトーシスと炎症の抑制により成体造血の恒常性維持に重要な役割を果たす(A20 plays critical roles in the homeostatic maintenance of adult hematopoiesis by prohibiting apoptosis and inflammation). 日本癌学会総会記事. 2013. 72回. 232-232

Books (3)：

内藤財団時報 vol.102, ヒストン修飾の脱制御とがん化
公益財団法人内藤記念科学振興財団 2018
血液内科 Vol.76 No.2, CMMLにおけるCbl遺伝子変異の意義
科学評論社 2018
臨床血液 Vol.58 No.5, Introduce My Article
日本血液学会 2017

Lectures and oral presentations (53)：

Dysregulation of transcription and genome stability caused by H3K36M in head and neck squamous cell carcinoma
(2023 Florida Academic Cancer Center Alliance (FACCA) Annual Retreat 2023)
Dysregulation of transcription and genome stability caused by H3K36M in head and neck squamous cell carcinoma
(The 5th Biennial Miami Epigenetics and Cancer Symposium 2022)
Epigenetic dysregulation associated with H3K36M in head and neck squamous cell carcinoma
(2021 Sylvester Annual Retreat Communication 2021)
PRC2 ACTIVITY DETERMINES SENSITIVITY TO PARP1/2 INHIBITORS IN H3K36M HEAD AND NECK SQUAMOUS CELL CARCINOMAS
(2021 Sylvester Annual Retreat Communication 2021)
DNA損傷修復反応におけるH3K4me3制御の解明
(第42回日本分子生物学会年会 2019)

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Education (1)：

- 2015 Hiroshima University Graduate School of Biomedical & Health Sciences

Professional career (1)：

医学 (広島大学)

Work history (6)：

2023/10 - 現在東京女子医科大学実験動物研究所客員講師
2023/07 - 現在千葉大学大学院医学研究院疾患システム医学特任助教
2020/01 - 2023/07 University of Miami-Miller School of Medicine, Sylvester Comprehensive Cancer Center Cancer Epigenetics Program Chromatin Dynamics in Stem Cells and Cancer Lab Postdoctoral fellow
2017/04 - 2020/01 Research Institute for Radiation Biology and Medicine, Hiroshima University Department of Disease Model Assistant Professor
2015/10 - 2017/03 Japan Society for the Promotion of Science Postdoctoral fellow (PD)

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Awards (5)：

2020 - The Kanae Foundation for the Promotion of Medical Science The Kanae Foundation for the Promotion of Medical Science 2020 Research Fellowship
2019 - 上原記念生命科学財団 2019年度海外留学助成リサーチフェローシップ
2018 - 花王芸術・科学財団平成30年度花王科学奨励賞 (医学・生物学分野)
2017 - Blood, Inside Blood Commentary,
2014 - 理研バイオリソースセンター Mouse of the Month Archive

Association Membership(s) (4)：

日本エピジェネティクス研究会 , THE JAPANESE BIOCHEMICAL SOCIETY , The molecular biology society of Japan , Japanese society of hematology

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