Inoue Shin'ichi

イノウエシンイチ | Inoue Shin'ichi

Affiliation and department：
Other affiliations (1)：

遺伝医療学分野遺伝科助教

Research field (4)： Molecular biology , Medical biochemistry , Cardiology , Fetal medicine/Pediatrics

Research keywords (27)： obesity , myogenic differentiation , esophageal dilation , fibrosis , hypoglycemia , growth retardation , mitochondria , cholesterol metabolism , lipid metabolism , cardiomyopathy , bone disease , cytochrome P450 , MEK inhibitor , Incurable disease , congenital heart defects , SREBP , RAS/MAPK , oncogene , energy metabolism , RIT1 , Mouse model , Costello syndrome , Noonan syndrome , HRAS , BRAF , Cardio-facio-cutaneous syndrome , RASopathies

Research theme for competitive and other funds (9)：

2018 - 2020 CFC症候群の心疾患におけるヒストン修飾の役割の解明
2018 - 2020 小児先天異常症における代謝システム制御機構とがん細胞代謝とのクロストーク
2017 - 2019 シグナル伝達異常症のハイスループット機能解析系構築とモデル生物における病態解明
2017 - 2019 細胞内シグナル伝達異常による先天性疾患の新しい治療パスウェイ検索と治療法開発
2016 - 2017 先天奇形症候群におけるメタボリックパスウェイと体重制御メカニズムの研究

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Papers (18)：

Taiki Abe, Ikumi Umeki, Shin-Ichiro Kanno, Shin-Ichi Inoue, Tetsuya Niihori, Yoko Aoki. LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases. Cell death and differentiation. 2019. 27. 3. 1023-1035
Tetsuya Niihori, Koki Nagai, Atsushi Fujita, Hirofumi Ohashi, Nobuhiko Okamoto, Satoshi Okada, Atsuko Harada, Hirotaka Kihara, Thomas Arbogast, Ryo Funayama, et al. Germline-Activating RRAS2 Mutations Cause Noonan Syndrome. American journal of human genetics. 2019. 104. 6. 1233-1240
Shingo Takahara, Shin-Ichi Inoue, Sachiko Miyagawa-Tomita, Katsuhisa Matsuura, Yasumi Nakashima, Tetsuya Niihori, Yoichi Matsubara, Yoshikatsu Saiki, Yoko Aoki. New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis. EBioMedicine. 2019. 42. 43-53
Ikumi Umeki, Tetsuya Niihori, Taiki Abe, Shin-Ichiro Kanno, Nobuhiko Okamoto, Seiji Mizuno, Kenji Kurosawa, Keisuke Nagasaki, Makoto Yoshida, Hirofumi Ohashi, et al. Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes. Human genetics. 2019. 138. 1. 21-35
Inoue SI, Morozumi N, Yoshikiyo K, Maeda H, Aoki Y. C-type natriuretic peptide improves growth retardation in a mouse model of cardio-facio-cutaneous syndrome. Human molecular genetics. 2019. 28. 1. 74-83

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MISC (31)：

梅木郁美, 新堀哲也, 阿部太紀, 長崎啓祐, 井上晋一, 藤原幾磨, 呉繁夫, 青木洋子. Noonan症候群の原因遺伝子LZTR1 臨床的特徴と結合タンパクRAF1/PPP1CBの同定. 日本内分泌学会雑誌. 2019. 95. 1. 382-382
大場大樹, 中嶌八隅, 新堀哲也, 山口清次, 松原洋一, 青木洋子, 井上晋一, 宮川幸子. 新規コステロ症候群モデルマウスを用いたエネルギー代謝変化の病態解明. 日本小児科学会雑誌. 2019. 123. 2. 284-284
梅木郁美, 新堀哲也, 岡本伸彦, 水野誠司, 黒沢健司, 長崎啓祐, 吉田真, 松原洋一, 藤原幾磨, 呉繁夫, et al. RASopathiesに対する網羅的遺伝子解析. 日本小児科学会雑誌. 2018. 122. 2. 229-229
Daiju Oba, Shin-ichi Inoue, Sachiko Miyagawa-Tomita, Yasumi Nakashima, Tetsuya Niihori, Seiji Yamaguchi, Yoichi Matsubara, Yoko Aoki. Mouse model of Costello syndrome: impaired hepatic energy homeostasis and resistance to high-fat diet induced obesity in mice with a heterozygous Hras G12S mutation. American Society of Human Genetics. 2018
Mouse model of Costello syndrome are resistant to high fat diet-induced obesity and exhibit impaired energy homeostasis. 日本人類遺伝学会第63回大会. 2018

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Patents (1)：

CFC症候群モデルマウスの作製とその治療法の確立

Books (1)：

ヌーナン症候群のマネジメント
メディカルレビュー社 2017 ISBN:9784779220029

Lectures and oral presentations (29)：

RASサブファミリータンパク質RIT1ノックインマウスにおける心疾患病態解析
(第92回日本生化学会大会 2019)
Metabolic Effects in Mouse Model of Costello syndrome
(6th International RASopathies Symposium 2019)
RASopathiesの病態解明と治療法開発 -臨床応用に向けて-
(第4回東北大学 Networking Evening 2019)
C-type natriuretic peptide improves growth retardation in a mouse model of cardio-facio-cutaneous syndrome associated with a Braf mutation
(European Human Genetics Conference Gothenburg 2019)
New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
(2019)

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Education (3)：

2008 - 2011 国立大学法人東北大学大学院薬学研究科
2006 - 2008 National Fisheries University
2002 - 2006 National Fisheries University

Professional career (1)：

薬学博士 (東北大学)

Work history (3)：

2015/08 - 現在 Tohoku University Graduate School of Medicine
2011/05 - 2015/07 Tohoku University Graduate School of Medicine
2011/04 - 2011/04 Tohoku University Graduate School of Medicine

Awards (2)：

2018 - 日本人類遺伝学会日本人類遺伝学会第63回大会大会最優秀口演賞
2015 - 4th International RASopathies Symposium, Young Investigator Award Travel Grant

Association Membership(s) (4)：

日本心臓血管発生研究会 , THE JAPAN SOCIETY OF HUMAN GENETICS , THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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