Suzuki Tsutomu

Affiliation and department：

Research field (1)： Molecular biology

Research theme for competitive and other funds (35)：

2018 - 2023 Dynamic regulation of RNA modification and biological process
2019 - 2021 Nanopore sequencing of RNA modifications
2015 - 2019 Support activities to promote international collaboration to accomplish the research on noncoding RNA neo-taxonomy
2014 - 2019 Chemical taxonomy of ncRNA
2014 - 2019 RNA modifications associated with biological processes

2013 - 2017 Molecular pathogenesis of ribosomopathies and defective ribosome CODE

2014 - 2016 Analysis of alternative pathway of tRNA maturation and pre-tRNA capping in tRNA maturation

2012 - 2016 動物ミトコンドリアにおける遺伝暗号成立基盤の解明

2013 - 2015 Epitranscriptome analysis of sporulating budding yeast

2010 - 2015 Post-transcriptional regulation associated with RNA modifications responsible for higher order biological processes

2011 - 2014 Structural basis and functional evolution of RNA maturation machinary

2011 - 2013 ペプチジルtRNAの脱落と新規翻訳制御機構の提唱

2010 - 2013 Ribosomal abnormalities and human diseases: Molecular pathogenesis of ribosomopathies

2011 - 2012 Exploring novel DNA modification toward paradigm shift of epigenetics

2008 - 2011 Study of ribosome maturation mechanism by the structural analysis of Rat-U13snoRNA complex

2010 - 2010 RNA修飾が関与する高次生命現象と遺伝子発現調節機構

2007 - 2009 Post-transcriptional regulation associated with RNA modifications responsible for higher order biological processes

2005 - 2009 Functional studies and biogenesis of RNA modifications

2005 - 2006 RNA修飾異常に起因する疾患の探索と分子機構の解明

2002 - 2006 Intermolecular Network specific for mitochondrial translation systems and its functional characteristics

2004 - 2005 ライシジン合成酵素を標的とした抗生物質の開発

2004 - 2004 ヒトRNAエディティング部位の探索とRNA修飾関連遺伝子群の網羅的同定

2003 - 2004 新規機能配列選択法を用いたリボソームRNAの機能解析

2002 - 2004 ミトコンドリア翻訳系の機能異常に起因する疾患の分子機構

2002 - 2003 アミノアシルtRNA合成酵素-tRNAネットワークにおける翻訳精度維持機構の研究

2002 - 2003 Elucidation of basic principle in genetic information translation system by using the specialty of animal mitochondria

2002 - 2002 新規機能配列選択法を用いたリボソームRNAの機能解析

2002 - 2002 バクテリアのtRNA修飾酵素遺伝子の網羅的同定とtRNA修飾塩基の機能解析

2001 - 2001 大腸菌の全tRNA修飾酵素遺伝子の同定とtRNA修飾塩基の網羅的機能解析

2000 - 2001 Taurine is a constituent of mammalian mitochondrial tRNAs ; new insights into the functions of taurine and human mitochondrial diseases

1999 - 2001 Elucidation of the construction principle of the mitochondria translation system by means of structural biology

1999 - 2000 TRANSLATION SYSTEM WITH COMPLEXITY

1998 - 2000 Analysis of functional structure of ribosomal RNA

1997 - 2000 Researches on ribozymes at molecular and atomic level

1998 - 1999 多義語コドンによる遺伝子発現機構と生物学的意義の解明

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Papers (273)：

Naho Akiyama, Kensuke Ishiguro, Takeshi Yokoyama, Kenjyo Miyauchi, Asuteka Nagao, Mikako Shirouzu, Tsutomu Suzuki. Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine. Nature Structural & Molecular Biology. 2024
Wei Lu, Naohiro Terasaka, Yuriko Sakaguchi, Takeo Suzuki, Tsutomu Suzuki, Hiroaki Suga. An anticodon-sensing T-boxzyme generates the elongator nonproteinogenic aminoacyl-tRNA in situ of a custom-made translation system for incorporation. Nucleic Acids Research. 2024
Takayuki Ohira, Tsutomu Suzuki. Transfer RNA modifications and cellular thermotolerance. Molecular Cell. 2024. 84. 1. 94-106
Xuewei Zhao, Ding Ma, Kensuke Ishiguro, Hironori Saito, Shinichiro Akichika, Ikuya Matsuzawa, Mari Mito, Toru Irie, Kota Ishibashi, Kimi Wakabayashi, et al. Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell. 2023
Saori Ueda, Mikako Yagi, Ena Tomoda, Shinya Matsumoto, Yasushi Ueyanagi, Yura Do, Daiki Setoyama, Yuichi Matsushima, Asuteka Nagao, Tsutomu Suzuki, et al. Mitochondrial haplotype mutation alleviates respiratory defect of MELAS by restoring taurine modification in tRNA with 3243A > G mutation. Nucleic acids research. 2023. 51. 14. 7480-7495

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MISC (70)：

小川亜希子, 小川亜希子, 名切千彩恵, 志甫谷渉, 井上飛鳥, 川上耕季, 平塚寿々音, 青木淳賢, 青木淳賢, 伊藤康裕, et al. RNA修飾代謝物のN6-methyladenosine(m6A)は受容体応答を引き起こす新規液性因子である. 日本生化学会大会(Web). 2021. 94th. P-546
林紗千子, 七野悠一, 池田彩乃, 松井将也, 鈴木健夫, 鈴木勉, 岩崎信太郎, 岩崎信太郎, 吉久徹. 出芽酵母におけるシステマティックな遺伝子改変をベースにしたtRNA機能の解析. 日本RNA学会年会要旨集. 2019. 21st. 49
Tsutomu Suzuki. Transcriptome-wide identification of A-to-I RNA editing sites using ICE-seq. Methods (San Diego, Calif.). 2019. 156. 66-78
長尾翌手可, 中西由衣, 山口悠太郎, 藤田智也, 藤田智也, 岩崎信太郎, 宮内健常, 坂口裕理子, 鈴木勉. 翻訳伸長脱落ペプチジルtRNAの網羅的解析と新規翻訳精度維持機構の探索. 日本生化学会大会(Web). 2019. 92nd
伏見拓矢, 市本景子, 鶴岡智子, 堀江弘, 岡崎康司, 大竹明, 加藤いづみ, 大塚春美, 鈴木勉, 村山圭. ミトコンドリアtRNA成熟化障害(QRSL1異常)による新生児ミトコンドリア病(世界初報告例). 日本小児科学会雑誌. 2017. 121. 10. 1755-1755

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Professional career (1)：

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