Shibata Takuma

シバタタクマ | Shibata Takuma

Affiliation and department：
Job title：助教

Research field (1)： Immunology

Research keywords (7)： TLR8 , TLR7 , Histiocytosis , Autoinflammatory Diseases , Autoimmunity , Toll Like Receptor , Innate Immunity

Research theme for competitive and other funds (13)：

2023 - 2027 Lysosomes as the starting point of innate immune responses - importance of lysosomal environment -
2022 - 2025 Toll様受容体8に着目したシェーグレン症候群の新たな診断・治療戦略
2021 - 2024 Toll様受容体7シグナルに着目したIgG4関連疾患の新規治療法の開発
2020 - 2023 IgG4関連疾患の免疫学的特異性を基盤とした病因解明と疾患モデルマウスによる検証
2019 - 2022 Elucidating the significance of amplified expression of endogenous retrotransposon in autoimmune/autoinflammatory diseases

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Papers (63)：

Kensuke Miyake, Takuma Shibata, Ryutaro Fukui, Yusuke Murakami, Ryota Sato, Ryosuke Hiranuma. Endosomal Toll-Like Receptors as Therapeutic Targets for Autoimmune Diseases. Advances in experimental medicine and biology. 2024. 1444. 97-108
Ryosuke Hiranuma, Ryota Sato, Kiyoshi Yamaguchi, Satoshi Nakamizo, Kenichi Asano, Takuma Shibata, Ryutaro Fukui, Yoichi Furukawa, Kenji Kabashima, Kensuke Miyake. Aberrant monocytopoiesis drives granuloma development in sarcoidosis. International Immunology. 2023
Zhikuan Zhang, Takuma Shibata, Akiko Fujimura, Jiro Kitaura, Kensuke Miyake, Umeharu Ohto, Toshiyuki Shimizu. Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature. 2023. 622. 7981. 188-194
Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa, et al. TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. Journal of Experimental Medicine. 2023. 220. 9
Ryota Sato, Kaiwen Liu, Takuma Shibata, Katsuaki Hoshino, Kiyoshi Yamaguchi, Toru Miyazaki, Ryosuke Hiranuma, Ryutaro Fukui, Yuji Motoi, Yuri Fukuda-Ohta, et al. Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5L^hihepatic macrophages. 2023

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MISC (54)：

KOBAYASHI Yohei, SHIMIZU Yuri, SATO Ryota, FUKUI Ryutaro, SHIBATA Takuma, MIYAKE Kensuke. CD20 promotes BCR/TLR9 dependent cell proliferation by enhancing TLR9/IgM association. 日本免疫学会総会・学術集会記録(CD-ROM). 2024. 52
坂庭賢太朗, 柴田琢磨, 重松秀樹, 山本雅貴, 三宅健介, 大戸梅治, 清水敏之. TLR3は効率的なシグナル伝達のためにdsRNA上で多量体を形成する. 日本薬学会年会要旨集. 2022. 142年会. 27C-am05S
SATO Ryota, LIU Kaiwen, SHIBATA Takuma, FUKUI Ryutaro, HOSHINO Katsuaki, KAISHO Tsuneyasu, MIYAKE Kensuke. The role of RNase T2 in macrophage homeostasis. 日本免疫学会総会・学術集会記録(CD-ROM). 2022. 51
SATO Ryota, LIU Kaiwen, SHIBATA Takuma, MIYAKE Kensuke, FUKUI Ryutaro, HOSHINO Katsuaki, KAISHO Tsuneyasu. The role of RNase T2 in macrophage homeostasis. 日本免疫学会総会・学術集会記録(CD-ROM). 2021. 50
木部琴乃, 木部琴乃, 柴田琢磨, 森山雅文, 森山雅文, 三宅健介, 中村誠司. Toll様受容体によって誘導される唾液腺炎病態の解明. 日本シェーグレン症候群学会学術集会プログラム・抄録集. 2021. 29th. 2. 112-113

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Education (3)：

Work history (4)：

2023/04 - 現在東京大学医科学研究所感染遺伝学分野准教授
2013/01 - 2023/03 The Institute of Medical Science, The University Of Tokyo Division of Infectious Genetics Assistant Professor
2012/10 - 2013/12 The Institute of Medical Science, The University Of Tokyo Division of Infectious Genetics Project Assistant Professor
2009/04 - 2012/09 The Institute of Medical Science, The University Of Tokyo Division of Infectious Genetics postdoctoral fellow

Awards (2)：

2016 - International Immunology International Immunology Outstanding Merit Award Guanosine and its modified derivatives are endogenous ligands for TLR7
2016 - The University of Tokyo Tokyo University Excellent Young Researchers

Association Membership(s) (2)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR IMMUNOLOGY

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