Matsuzaki Hirokazu

マツザキヒロカズ | Matsuzaki Hirokazu

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Pharmacology

Research keywords (2)：神経薬理 , 行動薬理

Research theme for competitive and other funds (10)：

2024 - 2027 Fundamental research of antitumor activity of darinaparsin, a novel organic arsenical, against leukemic cells
2024 - 2027 認知機能障害に対する新規クルクミン誘導体の予防・改善効果に関する基礎研究
2024 - 2027 抗ネクロトーシス作用を持ち合わせた安全性が高い抗酸化化合物の探索と脳保作用の検討
2021 - 2024 うつ様症状に対するクルクミン誘導体CUD003の予防・改善効果に関する基礎研究
2020 - 2023 Fundamental research of antitumor activity of arsenic compound in combination with active bufadienolide compounds against glioblastoma cells

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Papers (14)：

Takashi Asano, Meiyan Xuan, Naohiro Iwata, Jun Takayama, Kousuke Hayashi, Yosuke Kato, Toshiya Aoyama, Hiroshi Sugo, Hirokazu Matsuzaki, Bo Yuan, et al. Involvement of the Restoration of Cerebral Blood Flow and Maintenance of eNOS Expression in the Prophylactic Protective Effect of the Novel Ferulic Acid Derivative FAD012 against Ischemia/Reperfusion Injuries in Rats. International journal of molecular sciences. 2023. 24. 11
Bo Yuan, Jingmei Li, Shin-Ich Miyashita, Hidetomo Kikuchi, Meiyan Xuan, Hirokazu Matsuzaki, Naohiro Iwata, Shinya Kamiuchi, Katsuyoshi Sunaga, Takeshi Sakamoto, et al. Enhanced Cytotoxic Effects of Arenite in Combination with Active Bufadienolide Compounds against Human Glioblastoma Cell Line U-87. Molecules (Basel, Switzerland). 2022. 27. 19
Kaho Ogawa, Masaki Uchida, Tsutomu Yamaki, Hirokazu Matsuzaki, Mitsutoshi Kimura, Mari Okazaki, Hiroyuki Uchida, Hideshi Natsume. Delivery of acetaminophen to the central nervous system and the pharmacological effect after intranasal administration with a mucoadhesive agent and absorption enhancer. International journal of pharmaceutics. 2021. 594. 120046-120046
Kohei Kawabata, Hirokazu Matsuzaki, Sahoko Nukui, Mari Okazaki, Ayako Sakai, Yoichi Kawashima, Naomi Kudo. Perfluorododecanoic Acid Induces Cognitive Deficit in Adult Rats. Toxicological sciences : an official journal of the Society of Toxicology. 2017. 157. 2. 421-428
Takashi Asano, Hirokazu Matsuzaki, Naohiro Iwata, Meiyan Xuan, Shinya Kamiuchi, Yasuhide Hibino, Takeshi Sakamoto, Mari Okazaki. Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats. International journal of molecular sciences. 2017. 18. 3

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MISC (4)：

Hirokazu Matsuzaki, Takeshi Izumi, Machiko Matsumoto, Taku Yamaguchi, Takayuki Yoshida, Takahiro Horinouchi, Shuken Boku. Early postnatal stress affects the hippocampal postsynaptic 5-HT1A receptor function in context-dependent conditioned fear in adult rats. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2010. 112. 178P-178P
Takeshi Izumi, Takeshi Inoue, Kotaro Konno, Hirokazu Matsuzaki, Takayuki Yoshida, Taku Yamaguchi, Masahiko Watanabe, Tsukasa Koyama, Mitsuhiro Yoshioka. Characterization and functional meaning of the conditioned fear-related neural cells in the basolateral amygdala. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2009. 109. 57P-57P
Chika Judo, Machiko Matsumoto, Riki Hirata, Hirokazu Matsuzaki, Taku Yamaguchi, Takeshi Izumi, Mitsuhiro Yoshioka, Hiroko Togashi. Functional correlates between the stress-induced synaptic response and anxiety-related behavior in early postnatal stressed male and female rats. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2009. 109. 132P-132P
H Matsuzaki, M Matsumoto, T Yamaguchi, K Higuchi, K Ohno, M Terado, M Yoshioka, H Togashi. Behavioral effects of the early postnatal stress on emotional expressions in male and female rats. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2006. 100. 145P-145P

Patents (3)：

抗うつ剤
睡眠改善剤
嚥下障害改善剤

Books (1)：

Translational Methods for PTSD Research
Springer 2023 ISBN:9781071632185

Lectures and oral presentations (90)：

フェルラ酸誘導体FAD012の単回腹腔内投与は光血栓性脳卒中ラットの血液脳関門障害を軽減する
(日本薬学会第144年会)
フェルラ酸誘導体の抗酸化作用と細胞保護効果の構造活性相関
(日本薬学会第144年会)
ラット脳微小血管内皮細胞のH2O2誘発壊死性細胞死に対するフェルラ酸誘導体FAD012の保護メカニズムの検討
(日本薬学会第144年会)
クルクミン誘導体CUD003はラットのスコポラミン誘発の学習障害を改善する
(日本薬学会第144年会)
Neuro-2a細胞におけるH2O2誘発ネクローシス様細胞死に対するFAD041の抑制効果の検討
(日本薬学会第144年会)

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Education (3)：

2006 - 2010 Hokkaido University Graduate School, Division of Medicine
2004 - 2006 Health Sciences University of Hokkaido Graduate School, Division of Pharmaceutical Sciences
- 2004 Health Sciences University of Hokkaido Faculty of Pharmaceutical Science

Work history (2)：

2018/04 - 現在 Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Assistant Professor
2010/04 - 2018/03 Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Research Assistant

Association Membership(s) (2)：

日本薬学会 , 日本薬理学会

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