Research theme for competitive and other funds (3)：
2021 - 2026 Discovery and characterization of a pressure sensation and transduction (PREST) mechanism in the presynaptic terminal in the CNS.
2020 - 2025 From the structure-function relationship of dendrtic spines to synaptic mechanobiology
2020 - 2021 From structural plasticity of dendritic spines to synaptic mechano-biology
Papers (10)：
Haruo Kasai, Hasan Ucar, Yuichi Morimoto, Fumihiro Eto, Hitoshi Okazaki. Mechanical transmission at spine synapses: Short-term potentiation and working memory. Current Opinion in Neurobiology. 2023. 80. 102706-102706
Forceful synapses reveal mechanical interactions in the brain. Nature. 2021
Hasan Ucar, Satoshi Watanabe, Jun Noguchi, Yuichi Morimoto, Yusuke Iino, Sho Yagishita, Noriko Takahashi, Haruo Kasai. Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis. Nature. 2021. 600. 7890. 686-689
Jun Noguchi, Akira Nagaoka, Tatsuya Hayama, Hasan Ucar, Sho Yagishita, Noriko Takahashi, Haruo Kasai. Bidirectional in vivo structural dendritic spine plasticity revealed by two-photon glutamate uncaging in the mouse neocortex. Scientific reports. 2019. 9. 1. 13922-13922
Kazuhiko Ishii, Akira Nagaoka, Yutaro Kishida, Hitoshi Okazaki, Sho Yagishita, Hasan Ucar, Noriko Takahashi, Nobuhito Saito, Haruo Kasai. In vivo volume dynamics of dendritic spines in the neocortex of wild-type and Fmr1 KO mice. ENEURO. 2018. 18. 0282
Potentiation of presynaptic functions by mechanical forces generated by spine enlargement
(Annual Meeting of Society of Neuroscience 2018, San Diego 2018)
Mechanical forces caused by dendritic spine enlargement potentiate presynaptic trans-SNARE formation and release probability
(The 40th Annual Meeting of the Japan Neuroscience Society 2017)
FRET-FLIM measurement with a trans-SNARE-probe detecting the mechanical force from dendritic spine to pre-synaptic bouton
(The 39th Annual Meeting of the Japan Neuroscience Society 2016)
Education (3)：
2008 - 2013 Tokyo Institute of Technology Biological Information PhD
2006 - 2008 Tokyo Institute of Technology Biological Information MSc
2002 - 2006 Middle East Technical University Molecular Biology and Genetics Undergraduate
Work history (3)：
2021/04 - 現在 The University of Tokyo IRCN (International Research Center for Neurointelligence) Project Assistant Professor
2018/01 - 2021/03 The University of Tokyo IRCN (International Research Center for Neurointelligence) Project Researcher
2013/10 - 2017/12 The University of Tokyo Graduate School of Medicine Project Researcher
