Rchr
J-GLOBAL ID：201801012041503315   Update date: Sep. 02, 2024

Eita Sasaki

ササキ エイタ | Eita Sasaki
Affiliation and department：
Keio University Faculty of Pharmacy Department of Pharmaceutical Sciences

About Keio University Faculty of Pharmacy Department of Pharmaceutical Sciences


Job title： Assistant Professor/Senior Assistant Professor
Homepage URL  (1)： http://keio-analchem.jp
Research field  (3)： Nanobioscience ,  Chemical biology ,  Bioorganic chemistry
Research keywords  (5)： fluorescence probe ,  self-assembly ,  protein cage ,  chemical biology ,  protein engineering
Research theme for competitive and other funds  (5)：
  • 2024 - 2027 老化細胞特異的マーカーの網羅的探索と新規皮膚抗老化治療の開発
  • 2022 - 2025 細菌のタンパク質コンパートメントを基にした機能性人工シェルの創成
  • 2019 - 2022 メタボライト-シグナル連関による骨格筋恒常性維持機構の解明とその食品分野への応用
  • 2019 - 2022 多様な自然抗体と食を起源とする抗原の相互作用に関する研究
  • 2017 - 2019 Development of fluorescent probes for acrolein, a product of lipid peroxidation
Papers (26)：
  • Kenjiro Hanaoka, Takayuki Ikeno, Shimpei Iwaki, Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Fumiya Tao, Nobuhiko Kojima, Hisashi Ohno, Eita Sasaki, et al. A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT). Science advances. 2024. 10. 7. eadi8847
  • Mizuki Sugimoto, Eita Sasaki, Hisashi Ohno, Takayuki Ikeno, Sota Yamada, Kenjiro Hanaoka. Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT). Chemical and Pharmaceutical Bulletin. 2024
  • Honami Echizen, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryota Hibi, Sachiko Toma-Fukai, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Yukihiro Tsuchiya, et al. Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation. Scientific reports. 2023. 13. 1. 16456-16456
  • Kenjiro Hanaoka, Shimpei Iwaki, Kiyoshi Yagi, Takuya Myochin, Takayuki Ikeno, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Motokazu Uchigashima, et al. General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process. Journal of the American Chemical Society. 2022. 144. 43. 19778-19790
  • Recent Advances in Non-Viral Protein Shell Engineering and its Future. JSMI Report. 2022. 15. 2. 11-16
ｍore...
MISC (5)：
Patents (6)：
  • ミトコンドリアにおけるタンパク質合成を検出する蛍光プローブ
  • γ-グルタミルトランスペプチダーゼ5(GGT5)を検出する蛍光色素
  • フタロシアニン色素およびその製造方法、並びにフタロシアニン色素を含む薬剤
  • 核酸検出用蛍光色素
  • MMP12を指標とした免疫介在性炎症性疾患の診断、及びMMP12阻害による免疫介在性炎症性疾患の治療用医薬
ｍore...
Books (2)：
  • “Chemical Approaches to Discover Selective Inhibitors of Sulfurtransferases and Transsulfuration Enzymes.” In Sulfurtransferases Essential Enzymes for Life
    Elsevier 2023
  • クライオ電顕による小さなタンパク質の構造解析法 (実験医学)
    羊土社 2018
Education (4)：
  • 2005 - 2011 The University of Texas at Austin Department of Chemistry and Biochemistry
  • 2005 - 2011 The University of Texas at Austin Department of Chemistry (PhD)
  • 2003 - 2005 The University of Tokyo Graduate School of Pharmaceutical Sciences (MS)
  • 1999 - 2003 The University of Tokyo Faculty of Pharmaceutical Sciences (BS)
Professional career (2)：
  • Ph.D.
  • Chemistry (The University of Texas at Austin)
Work history (9)：
  • 2022/04 - 現在 Keio University Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences Lecturer / Senior Assistant Professor
  • 2021/04 - 2022/03 Keio University Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences Project Lecturer
  • 2017/04 - 2021/03 The University of Tokyo Graduate School of Agricultural and Life Sciences Assistant Proffesor
  • 2014/04 - 2017/03 ETH Zurich Department of Chemistry and Applied Biosciences Postdoctoral Fellow
  • 2011/09 - 2017/03 ETH Zurich Department of Chemistry and Applied Biosciences Postdoc
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