Yamamura Aya

ヤマムラアヤ | Yamamura Aya

Affiliation and department：
Job title： Assitant Professor
Homepage URL (1)： http://www.aichi-med-u.ac.jp/physio2/

Research field (3)： Clinical pharmacy , Physiology , Pharmacology

Research keywords (7)：イオンチャネル創薬 , 受容体創薬 , Pulmonary arterial smooth muscle , Ion channel , Calcium signaling , Calcium-sensing receptor , Pulmonary hypertension

Research theme for competitive and other funds (8)：

2023 - 2026 Pathophysiological roles of Hippo signaling in pulmonary arterial hypertension
2022 - 2025 Drug discovery targeting ion channels for the treatment of pulmonary hypertension
2022 - 2025 G蛋白活性調節因子を標的とした治療の基礎検討
2020 - 2023 Signal pathways of calcium-sensing receptor in pulmonary hypertension
2019 - 2022 A role of Activator of G-protein signaling 8 in pulmonary hypertension

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Papers (50)：

Aya Yamamura, Moe Fujiwara, Akiko Kawade, Taiki Amano, Alamgir Hossain, Md Junayed Nayeem, Rubii Kondo, Yoshiaki Suzuki, Yasumichi Inoue, Hidetoshi Hayashi, et al. Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension. European journal of pharmacology. 2024. 176564-176564
Natsumi Shima, Aya Yamamura, Moe Fujiwara, Taiki Amano, Kazuyuki Matsumoto, Taiga Sekine, Haruka Okano, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura. Up-regulated expression of two-pore domain K+ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension. Frontiers in cardiovascular medicine. 2024. 11. 1343804-1343804
Masashi Ishida, Aya Yamamura, Moe Fujiwara, Taiki Amano, Mina Ota, Yukari Hikawa, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura. Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles. Journal of pharmacological sciences. 2023. 153. 2. 84-88
Akiko Kawade, Aya Yamamura, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura. Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling. Journal of pharmacological sciences. 2023. 151. 2. 119-127
Taiki Amano, Aya Yamamura, Moe Fujiwara, Seiji Hirai, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura. Upregulated ClC3 channels/transporters elicit swelling-activated Cl- currents and induce excessive cell proliferation in idiopathic pulmonary arterial hypertension. Biological & pharmaceutical bulletin. 2022. 45. 11. 1684-1691

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MISC (8)：

Shanshan Song, Aya Yamamura, Hisao Yamamura, Aleksandra Babicheva, Haiyang Tang, Ramon J. Ayon, Kimberly M. McDermott, Xutong Sun, Stephen M. Black, Ayako Makino, et al. Hot, Heat and Stretch All Contribute to the Enhanced Ca2+ Signaling in Pulmonary Arterial Hypertension. FASEB JOURNAL. 2016. 30
Haiyang Tang, Aya Yamamura, Dustin R. Fraidenburg, Shanshan Song, Hisao Yamamura, Jiwang Chen, Yali Gu, Ramon J. Ayon, Stephan M. Black, Joe G. N. Garcia, et al. Calcium-sensing Receptor, Coupled with Transient Receptor Potential Canonical Channels 6, Regulates Cytosolic [Ca2+] in the Development and Progression of Pulmonary Hypertension. FASEB JOURNAL. 2016. 30
Ramon Ayon, Nicole Pohl, Aya Yamamura, Hisao Yamamura, Ayako Makino, Jason Yuan. miRNA-29b Directly Downregulates K+ Channel Expression and Function in IPAH-PASMC. FASEB JOURNAL. 2015. 29
Aya Yamamura, Kikuo Tsukamoto, Naoki Ohara, Jason X. -J. Yuan. Functional coupling of TRPC6 channel with Ca2+-sensing receptor in pulmonary hypertension. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 89P-89P
Yasuko Kozaki, Yuka Hasegawa, Yukako Mizukami, Rena Umetsu, Chinami Ishikawa, Yukie Nakagawa, Yuri Morikawa, Haruhi Yasue, Aya Yamamura, Kazuya Kitamori. Cutaneous mechanical hyperalgesia induced by a high -fat- cholesterol diet in SHRSP5/Dmcr rats : upregulation of Mss4 in dorsal root ganglion cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S162-S162

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Patents (1)：

肺動脈性肺高血圧症等の治療剤及びその利用

Education (3)：

2003 - 2007 Nagoya City University Graduate School of Medical Sciences
2001 - 2003 Nagoya City University Graduate School of Pharmaceutical Sciences
1997 - 2001 Meijo University Faculty of Pharmacy Department of Pharmacy

Professional career (1)：

Ph.D. (Nagoya City University)

Work history (4)：

2019/05 - 現在 Aichi Medical University School of Medicine
2017/05 - 2019/04 Aichi Medical University School of Medicine
2012/04 - 2017/04 Kinjo Gakuin University College of Pharmacy
2010/10 - 2012/03 イリノイ大学シカゴ校医学部博士研究員

Committee career (5)：

2019/04 - 現在日本生理学会学術評議員
2017/04 - 現在日本薬理学会学術評議員
2013/08 - 現在日本平滑筋学会若手の会世話人
2013/04 - 現在日本薬学会薬理系薬学部会若手世話人
2015/04 - 2017/03 日本薬学会ファルマシアトピックス小委員

Awards (4)：

2022/08 - 日本薬学会薬理系薬学部会令和3年度日本薬学会薬理系薬学部会奨励賞
2015/07 - 日本薬学会東海支部平成27年度学術奨励賞
2014/03 - 第87回日本薬理学会年会優秀発表賞
2013/08 - 日本平滑筋学会第9回栗山熙賞

Association Membership(s) (4)：

JAPAN SOCIETY OF SMOOTH MUSCLE RESEARCH , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE PHYSIOLOGICAL SOCIETY OF JAPAN , THE JAPANESE PHARMACOLOGICAL SOCIETY

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