Rchr
J-GLOBAL ID：201801012299704234
Update date: Sep. 27, 2024
Takuya Fukazawa
フカザワ タクヤ | Takuya Fukazawa
Affiliation and department：
Job title：
Associate Professor
Research field (3)：
Respiratory surgery
, Tumor biology
, Molecular biology
Research keywords (4)：
呼吸器外科
, 分子標的治療
, ゲノム編集
, オルガノイド
Research theme for competitive and other funds (20)：
- 2024 - 2027 非小細胞肺癌の再発と予後に関わるゲノムの倍加、不均一性の解析
- 2023 - 2026 Elucidation of the pathogenesis and development of personalized medicine for esophageal adenocarcinoma arisen from Barrett's esophagus using patient-derived organoids.
- 2022 - 2025 オルガノイドを用いた肺大細胞神経内分泌癌の分子病態および発癌メカニズムの解明
- 2021 - 2024 BRAF non-V600E変異陽性肺癌に対する新規治療法の開発
- 2020 - 2023 アカデミア創薬による肺扁平上皮癌治療のための新規臨床化合物の開発
- 2019 - 2023 オルガノイド技術を用いた食道癌の幹細胞性を標的とする新規治療法の開発
- 2019 - 2022 Elucidation of mechanism of carcinogenesis and progression in lung squamous cell carcinoma with organoid technology
- 2017 - 2020 Development of strategies to treat malignant mesothelioma by novel PIK3CA inhibitors
- 2016 - 2019 Identification of novel candidate compounds for the treatment of lung squamous cell carcinoma by academic drug discovery
- 2016 - 2018 癌関連遺伝子の発現を多重制御するエピゲノム編集ベクターの開発と応用
- 2014 - 2017 Development of artificial transcription factors for the treatment of lung and esophageal squamous cell carcinoma
- 2013 - 2016 Sox2 is a novel target gene for the treatment of lung squamous cell carcinoma.
- 2012 - 2015 Antitumor effect of a novel HSP90 inhibitor in esophageal cancer cells
- 2011 - 2013 Development of novel molecular targeted therapies for the treatment of KRas mutated non small lung cancer using a HSP90 inhibitor
- 2011 - 2013 Development of novel therapies targeting esophageal cancer using Midkine inhibitors
- 2009 - 2011 Development of novel Myc and K-Ras targeted therapies for the treatment of lung cancer
- 2009 - 2011 Investigation of novel therapeutic alternative to gastrointestinal cancer using a HSP90 inhibitor
- 2008 - 2010 Targeting advanced non small cell lung cancer in vivo by pulmonary surfactant -adenovirus-mediated gene transfer
- 2007 - 2008 第三世代制限増殖ウイルスベクターを用いた瀰漫性胸膜中皮腫に対する新規治療法の開発
- 2006 - 2007 HUMAN NON-SMALL CELLLUNG CANCER TARGETED PROMOTER SYSTEM FOR GENE THERAPY
Show all
Papers (89)：
-
Nobuaki Ochi, Noriko Miyake, Masami Takeyama, Hiromichi Yamane, Takuya Fukazawa, Yasunari Nagasaki, Tatsuyuki Kawahara, Naruhiko Ichiyama, Youko Kosaka, Ayaka Mimura, et al. The combined inhibition of SLC1A3 and glutaminase in osimertinib-resistant EGFR mutant cells. Biochimica et Biophysica Acta (BBA) - General Subjects. 2024. 1868. 10
-
Etsuko Yokota, Miki Iwai, Yuta Ishida, Takuro Yukawa, Masaki Matsubara, Yoshio Naomoto, Hideyo Fujiwara, Yasumasa Monobe, Minoru Haisa, Nagio Takigawa, et al. Transforming tumoroids derived from ALK-positive pulmonary adenocarcinoma to squamous cell carcinoma in vivo. Human Cell. 2024. 37. 1132-1140
-
Etsuko Yokota, Miki Iwai, Takuro Yukawa, Yoshio Naomoto, Minoru Haisa, Yasumasa Monobe, Nagio Takigawa, Takuya Fukazawa, Tomoki Yamatsuji. Patient-derived tumoroid models of pulmonary large-cell neuroendocrine carcinoma: a promising tool for personalized medicine and developing novel therapeutic strategies. Cancer Letters. 2024. 588. 2024
-
Miki Iwai, Etsuko Yokota, Yuta Ishida, Takuro Yukawa, Yoshio Naomoto, Yasumasa Monobe, Minoru Haisa, Nagio Takigawa, Takuya Fukazawa, Tomoki Yamatsuji. Establishment and characterization of novel high mucus-producing lung tumoroids derived from a patient with pulmonary solid adenocarcinoma. Human Cell. 2024
-
Koichi Tomoshige, William D Stuart, Iris M Fink-Baldauf, Masaoki Ito, Tomoshi Tsuchiya, Takeshi Nagayasu, Tomoki Yamatsuji, Morihito Okada, Takuya Fukazawa, Minzhe Guo, et al. FOXA2 Cooperates with Mutant KRAS to Drive Invasive Mucinous Adenocarcinoma of the Lung. Cancer research. 2023. 83. 9. 1443-1458
ｍore...
Patents (2)：
-
扁平上皮癌に対する抗腫瘍剤
-
インスリン産生細胞特異的プロモーターおよびその用途
Books (1)：
-
【ゲノム編集の未来】ゲノム編集と治療 人工転写因子を用いた癌抑制技術開発
2020
Lectures and oral presentations (245)：
-
高い粘液産性能を持つ充実型肺腺癌患者由来オルガノイドの樹立と特性解析
(第83回日本癌学会学術総会 2024)
-
オルガノイドを用いた肺大細胞神経内分泌癌に対するオーロラ A キナーゼ標的療法の開発
(第83回日本癌学会学術総会 2024)
-
Development of preclinical models for lung large cell neuroendocrine carcinoma using organoids.
(The 124th Annual Congress of Japan Surgical Society 2024)
-
肺動静脈奇形の診断で切除した右上肺癌の1症例
(第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会 2022)
-
外科的治療が必要であったアキシチニブ投与後の難治性気胸の一例
(第66回日本呼吸器学会中国・四国地方会 2022)
ｍore...
Education (2)：
- - 1999 Okayama University
- - 1994 Okayama University
Work history (3)：
- 2016 - Kawasaki Medical School
- 2001 - University of California Riverside Department of Biomedical Science
- 1999 - The University of Texas M. D. Anderson Cancer Center
Committee career (2)：
- 2017 - 現在 日本呼吸器外科学会 評議員
- 2016 - 現在 日本呼吸器学会 中国・四国支部 評議員
Awards (2)：
- 2022 - 川崎医科大学 守分記念賞
- 2008 - 岡山医学会 がん研究奨励賞 (山田賞)
Association Membership(s) (9)：
日本細胞学会
, 日本癌治療認定機構
, 日本ゲノム編集学会
, 日本肺癌学会
, 日本呼吸器外科学会
, 日本胸部外科学会
, 日本癌学会
, American Association for Cancer Research
, 日本外科学会
