Hattori Shinichiro

Research field (1)： Virology

Research theme for competitive and other funds (2)：

2020 - 2023 HIVとHBVの逆転写酵素の構造比較・解析を基盤とした新規抗HBV薬開発への応用
2012 - 2012 HIV感染モデルマウスを用いたHIV感染早期におけるNK細胞の動態解明

Papers (69)：

Nobuyo Higashi-Kuwata, Mariko Kato, Shin-Ichiro Hattori, Yuki Takamatsu, Hiroaki Mitsuya. Tecovirimat is active against various MPXV strains, while cidofovir, brincidofovir, trifluridine, and gemcitabine have no detectable MPXV-specific antiviral activity. Virus research. 2025. 360. 199615-199615
Nobuyo Higashi-Kuwata, Haydar Bulut, Hironori Hayashi, Kohei Tsuji, Hiromi Ogata-Aoki, Maki Kiso, Nobutoki Takamune, Naoki Kishimoto, Shin-ichiro Hattori, Takahiro Ishii, et al. An orally available P1’-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier. PNAS Nexus. 2025
Arun K. Ghosh, Daniel Lee, Ashish Sharma, Megan E. Johnson, Ajay K. Ghosh, Yuan-Fang Wang, Johnson Agniswamy, Masayuki Amano, Shin-ichiro Hattori, Irene T. Weber, et al. Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies. Organic & Biomolecular Chemistry. 2024. 22. 36. 7354-7372
Shin-ichiro Hattori, Haydar Bulut, Hironori Hayashi, Naoki Kishimoto, Nobutoki Takamune, Kazuya Hasegawa, Yuri Furusawa, Seiya Yamayoshi, Kazutaka Murayama, Hirokazu Tamamura, et al. Structural and virologic mechanism of the emergence of resistance to M ^pro inhibitors in SARS-CoV-2. Proceedings of the National Academy of Sciences. 2024. 121. 37
Yoshiaki Yasutake, Shin-ichiro Hattori, Hiroki Kumamoto, Noriko Tamura, Kenji Maeda, Hiroaki Mitsuya. Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations. Scientific Reports. 2024. 14. 1

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MISC (36)：

渡部夏千, 長谷川えり, 大槻琴美, 六本木誠, 服部真一朗, 鍬田伸好, 満屋裕明, 紺野奇重. Synthesis of 4’-substituted carbocyclic nucleosides targeting SARS-CoV-2 RNA polymerase. 日本薬学会年会要旨集(Web). 2024. 144th
長谷川えり, 渡部夏千, 大槻琴美, 六本木誠, 服部真一朗, 鍬田伸好, 満屋裕明, 紺野奇重. Synthesis of carbovir derivatives as therapeutic agents for adenovirus infections. 日本薬学会年会要旨集(Web). 2024. 144th
大槻琴美, 高山彩光, 六本木誠, 服部真一朗, 鍬田伸好, 満屋裕明, 紺野奇重. Synthesis of 4’-substituted adenosine derivatives targeting SARS-CoV-2 RNA polymerase. 日本薬学会年会要旨集(Web). 2024. 144th
篠原功紀, 鍬田伸好, 辻耕平, 石井貴大, 小早川拓也, 服部真一朗, 岸本直樹, 高宗暢暁, 三隅将吾, HAYDAR Bulut, et al. Development of small molecule inhibitors with potent antiviral activity targeting SARS-CoV-2 main protease. 日本薬学会年会要旨集(Web). 2024. 144th
篠原功紀, 鍬田伸好, 辻耕平, 石井貴大, 小早川拓也, 服部真一朗, 岸本直樹, 高宗暢暁, 三隅将吾, BULUT Haydar, et al. フッ素化及びチオアミド置換を活用した新規SARS-CoV-2メインプロテアーゼ阻害剤の創製. 日本薬学会関東支部大会講演要旨集(CD-ROM). 2023. 67th

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Lectures and oral presentations (48)：

Synthesis of 4’-fluoro-carbocyclic adenosine targeting SARS-CoV-2 RNA polymerase
(日本薬学会年会要旨集(Web) 2023)
Development of SARS-CoV-2 Main Protease Inhibitors by Fluorine Substitution and Amide Bond Conversion
(日本薬学会年会要旨集(Web) 2023)
Synthesis of 4’-fluoro-carbocyclic uridine derivatives targeting SARS-CoV-2 RNA polymerase
(日本薬学会年会要旨集(Web) 2023)
ニルマトレルビルとその誘導体に耐性を示すSARS-CoV-2変異株の誘導と耐性獲得機序の解明
(日本エイズ学会誌 2023)
Nucleobase-Structure-activity relationship study of carbocyclic nucleosides as anti-SARS-CoV-2 agents
(日本薬学会年会要旨集(Web) 2022)

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