Research theme for competitive and other funds (26)：
2023 - 2026 Elucidation of MYCN/NCYM function in outer radial glial cell
2023 - 2026 Usefulness of ORF dominance as a novel biomarker in cholangiopancreatic cancer
2022 - 2025 Elucidation of the mechanisms underlying drug-resistance and development of predictive biomarker using patient-derived ovarian cancer organoids
2022 - 2025 Elucidation of the mechanisms underlying drug-resistance and development of therapeutic strategy of refractory cervical cancer using patient-derived organoids
2021 - 2024 Elucidation of genetic interactions underlying tumor development and metastasis using murine endometrial organoids
2021 - 2024 Elucidation of the mechanism underlying tumorigenesis and development of therapeutic strategy for uterine carcinosarcoma using murine and patient-derived organoids
2021 - 2024 NCYMによる分裂期制御機構とその神経芽腫発がんへの寄与の解明
2021 - 2024 Organoid-based modeling of gastric carcinogenesis and elucidation of its mechanism
2021 - 2024 Exploration of a novel therapeutic strategy of pancreatic cancers using organoid-based carcinogenesis model
2019 - 2022 An integrated study using patient-derived organoids toward elucidation of biological feature and development of therapeutic strategy of ovarian cancer
2019 - 2022 Research on carcinogenesis and cell differentiation using established human pancreatic acinar cell carcinoma cell line
2017 - 2020 Organoid-based Modeling of Endometrial Carcinogenesis
2017 - 2020 Integrative research on IPMN using organoids obtained from patients' pancreatic juice.
2016 - 2019 New Approach for Organoid Culture in Patients with Pancreatic Tumor
2015 - 2018 Revealing cancer-cell evolution and intra-tumor heterogeneity by single-cell genome and transcriptome analysis
2015 - 2017 Modeling for gastric carcinogenesis using normal gastric organoids
2014 - 2017 Lung carcinogenesis by genetic reconstitution using organoids derived from normal lung in mice
2014 - 2017 Elucidation of molecular mechanisms underlying colon carcinogenesis and discovery of therapeutic targets by using a novel in vitro model
2014 - 2016 Genetic reconstitution of pancreatic ductal carcinogenesis with murine primary cells
2004 - 2007 Systemic Analysis of transcriptional network in cancer
2005 - 2005 SNPアレイを用いたスキルス胃癌細胞株のゲノムコピー数解析
2003 - 2004 胃癌の分子標的に対する系統的モノクローナル抗体作成とその診断・治療への応用
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Papers (66)：
Yoshiaki Maru, Mami Kohno, Kiyomi Suzuka, Akiko Odaka, Mari Masuda, Akinobu Araki, Makiko Itami, Naotake Tanaka, Yoshitaka Hippo. Establishment and characterization of multiple patient-derived organoids from a case of advanced endometrial cancer. Human cell. 2024
Kazuma Nakatani, Hiroyuki Kogashi, Takanori Miyamoto, Taiki Setoguchi, Tetsushi Sakuma, Kazuto Kugou, Yoshinori Hasegawa, Takashi Yamamoto, Yoshitaka Hippo, Yusuke Suenaga. Inhibition of OCT4 binding at the MYCN locus induces neuroblastoma cell death accompanied by downregulation of transcripts with high-open reading frame dominance. Frontiers in oncology. 2024. 14. 1237378-1237378
Yusuke Toyohara, Ayumi Taguchi, Yoshiyuki Ishii, Daisuke Yoshimoto, Miki Yamazaki, Hiroko Matsunaga, Kazuma Nakatani, Daisuke Hoshi, Saki Tsuchimochi, Misako Kusakabe, et al. Identification of target cells of human papillomavirus 18 using squamocolumnar junction organoids. Cancer science. 2023
Jihang Yao, Keizo Takenaga, Nobuko Koshikawa, Yuki Kida, Jason Lin, Takayoshi Watanabe, Yoshiaki Maru, Yoshitaka Hippo, Seigi Yamamoto, Yuyan Zhu, et al. Anticancer effect of a pyrrole-imidazole polyamide-triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells. International journal of cancer. 2023. 152. 5. 962-976
Misako Kusakabe, Ayumi Taguchi, Michihiro Tanikawa, Daisuke Hoshi, Saki Tsuchimochi, Xi Qian, Yusuke Toyohara, Akira Kawata, Ryota Wagatsuma, Kohei Yamaguchi, et al. Application of organoid culture from HPV18-positive small cell carcinoma of the uterine cervix for precision medicine. Cancer medicine. 2023. 12. 7. 8476-8489
