Rchr
J-GLOBAL ID：201801012467275395   Update date: Apr. 13, 2026

Yoshida Tomoki

ヨシダ トモキ | Yoshida Tomoki
Affiliation and department：
Kitasato University School of Pharmacy, Faculty of Pharmacy・Department of Pharmaceutical Life Sciences, Laboratory of Physical Chemistry for Drug Design

About Kitasato University School of Pharmacy, Faculty of Pharmacy・Department of Pharmaceutical Life Sciences, Laboratory of Physical Chemistry for Drug Design


Job title： Assistant Professor
Research field  (4)： Pharmaceuticals - analytical and physicochemistry ,  Pharmaceuticals - analytical and physicochemistry ,  Basic physical chemistry ,  Pharmaceuticals - chemistry and drug development
Research keywords  (14)： computer simulation for drug design ,  水和サイト解析 ,  計算化学 ,  量子化学 ,  分子動力学法 ,  docking simulation ,  シミュレーション ,  量子化学計算 ,  分子間相互作用 ,  分子認識 ,  医薬分子設計 ,  結合自由エネルギー ,  フラグメント分子軌道法 ,  モンテカルロ法
Papers (18)：
  • Toshihiko Sugiki, Tomoki Yoshida, Masaki Tsukamoto, Koichiro Miyanishi, Akinori Kagawa, Natsuko Miura, Tomoto Ura, Jun Fukazawa, Yuko Hatanaka, Tsuyoshi Murata, et al. Investigation of the functional hot-spot residues of an enzyme by real-time monitoring of the enzymatic reaction using NMR and computational approaches. Scientific reports. 2026. 16. 1. 5896-5896
  • Koki Sadamori, Takuya Kubo, Tomoki Yoshida, Megumi Yamamoto, Yui Shibata, Kazuya Fukasawa, Kazuya Tokumura, Tetsuhiro Horie, Takuya Kadota, Ryotaro Yamakawa, et al. CDK8 inhibitor KY-065 rescues skeletal abnormalities in achondroplasia model mice. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2025. 1871. 3. 167626-167626
  • Atsushi Kato, Izumi Nakagome, Uta Kanekiyo, Tian-Tian Lu, Yi-Xian Li, Kosuke Yoshimura, Mana Kishida, Kenta Shinzawa, Tomoki Yoshida, Nobutada Tanaka, et al. 5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease. Journal of medicinal chemistry. 2022. 65. 3. 2329-2341
  • Natsuki Nambu, Huei-Fung Tsai, Yun C Chang, K J Kwon-Chung, Tomoki Yoshida, Nobutada Tanaka, Hiroshi Tomoda, Yutaka Ebizuka, Isao Fujii. Novel angular naphthopyrone formation by Arp1p dehydratase involved in Aspergillus fumigatus melanin biosynthesis. Environmental microbiology reports. 2021
  • Misawa K, Ozawa S, Yoshida T, Nakagome I, Yamaotsu N, Hirono S. Identifying inhibitors of USP7-HDM2 protein-protein interaction (PPI) by the in silico fragment-mapping method. Yakugaku Zasshi. 2019. 139. 5. 827-835
ｍore...
Lectures and oral presentations  (74)：
  • Identification of SARS-CoV-2 main protease inhibitor candidates effective against resistant variants using hydration site analysis
    (The 146th Annual Meeting of the Pharmaceutical Society of Japan 2026)
  • 水和サイト解析を用いたSARS-CoV-2メインプロテアーゼ阻害剤のバーチャルスクリーニング
    (日本薬学会 第145年会 2025)
  • 水和サイト解析を用いた新規バーチャルスクリーニング法の開発:SARS-CoV-2 PLpro阻害剤の探索への応用
    (第51回白金シンポジウム 2025)
  • In silicoアミノ酸マッピング法を使用した自動ペプチド設計プログラムの開発
    (第13回北里化学シンポジウム 2024)
  • ブテノリドダイマーの異性化の発見と反応機構の解析
    (第13回北里化学シンポジウム 2024)
ｍore...
Education (3)：
  • 2003 - 2007 Hiroshima University Graduate School of Science Graduate School of Science Department of Chemistry
  • 2001 - 2003 Hiroshima University Graduate School of Science Graduate School of Science Department of Chemistry
  • 1997 - 2001 Hiroshima University Faculty of Science Department of Chemistry
Professional career (1)：
  • Ph.D. (Hiroshima University)
Work history (7)：
  • 2014/04/01 - Assistant Professor, Kitasato University School of Pharmacy
  • 2012/04/01 - 2014/03/31 Visiting Researcher, Institute for interdisciplinary science (IIS), Graduate School of Science, Hiroshima University
  • 2012/04 - 2014/03 Visiting Researcher, Pacific Northwest National Labolratory
  • 2011/04/01 - 2012/03/31 Specially Appointed Assistant Professor, University Management Planning Office, Hiroshima University
  • 2010/04/01 - 2011/03/31 Specially Appointed Assistant Professor, Competitive Fund Promotion Office Director, Hiroshima University
Show all
Awards (3)：
  • 2016/11 - 日本薬学会構造活性相関部会、日本農薬学会農薬デザイン研究会 SAR Presentation Award Interaction analyses of CDK2 with its inhibitors by FMO calculation and PLS regression
  • 2004/12 - 第1回ナノ・バイオ・インフォ化学シンポジウム学生賞 タンパク質-DNAの特異的認識への計算化学からの取り組み: 側鎖-塩基対間の相互作用自由エネルギーマップ
  • 2002/11 - 日本化学会情報化学部会 第25回情報化学討論会ポスター賞 核酸塩基対-アミノ酸側鎖間の相互作用の加成性
Association Membership(s) (2)：
The Chemical Society of Japan ,  The Pharmaceutical Society of Japan
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