Research field (9):
Nanobioscience
, Nano/micro-systems
, Mechanics and mechatronics
, Robotics and intelligent systems
, Bio-, chemical, and soft-matter physics
, Applied physics - general
, Molecular biology
, Cell biology
, Genomics
Research keywords (13):
Lab on a chip
, Micro TAS
, マイクロ流体デバイス
, 光ピンセット
, ナノ計測
, 1分子イメージング
, オプティカルマッピング
, 1細胞解析
, エピゲノム
, クロマチン
, 高次構造転移
, 細胞医療
, ベシクル
Research theme for competitive and other funds (22):
2023 - 2026 Establishment of Ultrasound Control Technique of Microbubble-Encapsulated Vesicles and Its Medical Applications
2020 - 2023 細胞質移植マイクロ流体デバイス開発による高収率・細胞機能改変手法の創製
2020 - 2023 Reconstitution of Physiologically Relevant 3D Blood-Brain Barrier Model for the Elucidation of its Selective Transport Mechanism
2017 - 2020 Development of a microdevice for single cell/chromatin analysis to elucidate epigenomic dynamics
2014 - 2016 マイクロ流体デバイスを用いたゲノムサイズクロマチンの高次構造変化実時間観察
2013 - 2016 Development of a method for the epigenetic analysis of single cells under a micro fluidic device
2013 - 2015 Toward Developing a Microdevice for Elucidating the Mechanism of Blood-Nerve Interactions
2011 - 2015 Modification of cellular function based on cell fusion in microdevices
2011 - 2013 マイクロ流体デバイスを用いたクロマチンファイバーの個別操作・動態解明
2011 - 2012 Development of optically-driven tool for nano-bio processing and its applications in molecular dissection of genomic DNA
2010 - 2012 Development of a micro-device for manipulation and analysis of single genomic DNA molecules toward single cell analysis
2009 - 2010 ゲノムサイズクロマチンファイバーの単離と物性計測・高次構造解析
2008 - 2010 ゲノムDNA単分子解析と細胞サイズコアセルベート内での生化学反応制御・計測
2006 - 2007 ゲノムDNA単分子解析と細胞サイズベシクル中での生化学実験
2005 - 2007 Studies of elementary techniques for developing on-chip devices for single genomic DNA manipulation and analysis
2002 - 2005 Nonlinear Dynamics of Mesoscopic Systems under Laser Irradiation
2002 - 2003 Controlling Phase separation and Higher Order Structure of Chromosomal DNA Molecules
2000 - 2002 Kinetics and Dynamics of Pressure-induced Phase Transition in Amphiphilic Systems
1998 - 2000 Formation of Nano-Ordered Structure through Folding Transition of Single Polymer Chain
1998 - 2000 Thermodynamics and Kinetics on the Folding Transition of Single Molecular Chain
1998 - 1999 Phase Transitions in the Higher Order Structure of Giant DNA Single Molecular Chain
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Papers (52):
Kiyonori Noda, Hidehiro Oana. Toward single-cell epigenome analysis: A microfluidic device for isolating, stretching, and imaging individual chromosomes. Sensors and Actuators B: Chemical. 2023. 394. 134462-134462
Kennedy Omondi Okeyo, Ryuta Hiyaji, Hidehiro Oana. A single-cell surgery microfluidic device for transplanting tumor cytoplasm into dendritic cells without nuclei mixing. Biotechnology journal. 2023. 18. 1. e2200135
Yue Ma, Yuko Yoshikawa, Hidehiro Oana, Kenichi Yoshikawa. Marked Difference in the Conformational Transition of DNA Caused by Propanol Isomer. Polymers. 2020. 12. 7. 1607-1607
小穴 英廣, 野田 清敬. エピゲノム動態解明を目指した1細胞クロマチン解析・物性計測マイクロ流体デバイスの開発-Development of microfluidic devices for analysis of chromatins from single cells and measurement of their physical properties for elucidating epigenome dynamics. 細胞. 2022. 54. 11. 653-656
Kiyonori Noda, Hidehiro Oana. MOORING BOTH ENDS OF INTACT CHROMATIN FIBERS TO MICROSTRUCTURES IN A MICROFLUIDIC DEVICE FOR ACQUISITION OF EPIGENETIC INFORMATION BASED ON FLUORESCENCE MICROSCOPY. MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2021. 517-518
Kennedy O. Okeyo, Osamu Kurosawa, Hidehiro Oana, Masao Washizu. Modulating the cell adhesion microenvironment to mechanically drive trophectoderm-like organoid formation from human iPS cells. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. 2019. 290-291
A Microfluidic Device for Direct Observation-based Single Cell Epigenetic Analysis
(2022)
Development of a Microfluidic Device for Direct Observation-based Epigenetic Analysis of Individual Chromosomes
(Asian Conference on Analytical Sciences 2021 (ASIANALYSIS XV). 2021)
Isolation, Discrimination and Transportation of Individual Specific Chromosomes From Single Mammalian Cells in a Microfluidic Channel
(Lab-on-a-Chip & Microfluidics World Congress 2019 2019)
Development of single-cell epigenome analysis technology and cell function modification technology using microfluidic devices
(2019)
Developing a microfluidic device for direct observation-based single cell/chromosome epigenetic analyses
(Mini-symposium of Single Cell Sequencing, Biosensing and Biomicrofluidics 2018)