Sakamoto Takeharu

Affiliation and department：
Job title： Distinguished Professor appointed by the University President

Research field (1)： Tumor biology

Research theme for competitive and other funds (10)：

2024 - 2027 Elucidating mechanism of high-grade malignancy of lung adenocarcinoma focusing on carbohydrate antigen MECA-79
2022 - 2025 大腸がんにおけるオンコメタボライト・L-2HGの分子基盤の解明
2019 - 2023 Exploring novel mechanisms of chemotherapy-induced metastasis
2019 - 2021 Crosstalk between clonal hematopoiesis and solid tumors
2016 - 2019 Analysis of MT1-MMP-dependent molecular pathways in the diversity and transformation of hepatocellular carcinoma

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Papers (52)：

Yue Guo, Yutaka Kasai, Yuto Tanaka, Yuki Ohashi-Kumagai, Takeharu Sakamoto, Takeshi Ito, Yoshinori Murakami. IGSF3 is a homophilic cell adhesion molecule that drives lung metastasis of melanoma by promoting adhesion to vascular endothelium. Cancer science. 2024
Masahiro Hashimoto, Yasuhiro Kojima, Takeharu Sakamoto, Yuki Ozato, Yusuke Nakano, Tadashi Abe, Kiyotaka Hosoda, Hideyuki Saito, Satoshi Higuchi, Yuichi Hisamatsu, et al. Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis. EBioMedicine. 2024. 105102-105102
Noritaka Tanaka, Hikari Okada, Kiyoshi Yamaguchi, Masahide Seki, Daisuke Matsubara, Noriko Gotoh, Yutaka Suzuki, Yoichi Furukawa, Taro Yamashita, Jun-Ichiro Inoue, et al. Mint3-depletion-induced energy stress sensitizes triple-negative breast cancer to chemotherapy via HSF1 inactivation. Cell death & disease. 2023. 14. 12. 815-815
Nobuo Terada, Yurika Saitoh, Masaki Saito, Tomoki Yamada, Akio Kamijo, Takahiro Yoshizawa, Takeharu Sakamoto. Recent Progress on Genetically Modified Animal Models for Membrane Skeletal Proteins: The 4.1 and MPP Families. Genes. 2023. 14. 10. 1942-1942
Noritaka Tanaka, Takeharu Sakamoto. MT1-MMP as a Key Regulator of Metastasis. Cells. 2023. 12. 17

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MISC (12)：

田中伯享, 坂本毅治. 【がん遺伝子の発見は現代医療を進歩させたか】がん遺伝子研究の新しい展開 RAS遺伝子を中心としたがん治療戦略の確立. 生体の科学. 2023. 74. 4. 289-294
坂本毅治. 【がん微小環境に1細胞レベルで挑む技術革新で見えてきた腫瘍内の細胞と免疫応答の多様性、がん悪性化・治療抵抗性の鍵】(第3章)がん微小環境を標的とした治療薬と耐性 MMPを標的としたがん微小環境改変治療法の可能性. 実験医学. 2021. 39. 12. 1962-1967
坂本毅治. 【がんの進展における血管新生と免疫】炎症による転移の制御. 細胞. 2021. 53. 2. 80-83
坂本毅治. 【がん研究10か年戦略の成果と課題-基礎から実用化までをつなぐ研究開発】応用研究〜非臨床研究創薬/評価系がん細胞・がん間質細胞特異的な酸素センシング機構を標的としたがん微小環境標的薬剤の開発. 医学のあゆみ. 2019. 271. 9. 878-882
熊谷友紀, 伊東剛, 永田政義, 川合剛人, 坂本毅治, 松原大祐, 大場基, 村上善則. 肺腺がん細胞の実験的転移系を用いた転移関連分子の同定と機能解析(Screening of metastasis-related genes by microarray analysis of lung cancer cells using experimental lung metastasis). 日本癌学会総会記事. 2018. 77回. 1602-1602

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