Nakanishi Katsuhiro

Affiliation and department：

Research field (1)： Pharmaceuticals - health and biochemistry

Research keywords (5)：粘膜免疫 , 血管 , 免疫学 , 抗体 , 植物遺伝子工学

Research theme for competitive and other funds (3)：

2022 - 2025 腸内細菌由来の代謝物による腸血管のバリア機能の制御機構の解明
2019 - 2022 Production of secretory IgA immunoadhesin against mutiple mucosal pathogens using plant expression systems
2016 - 2019 広範な食中毒に適応可能な分泌型IgAイムノアドヘシンの作製と植物での生産

Papers (9)：

Katsuhiro Nakanishi, Taichi Takase, Yuya Ohira, Ryota Ida, Noriko Mogi, Yuki Kikuchi, Minami Matsuda, Kohta Kurohane, Yoshihiro Akimoto, Junri Hayakawa, et al. Prevention of Shiga toxin 1-caused colon injury by plant-derived recombinant IgA. Scientific Reports. 2022. 12. 1
Katsuhiro Nakanishi, Noriko Mogi, Yuki Kikuchi, Minami Matsuda, Takeshi Matsuoka, Kotome Shiina, Shota Morikane, Kohta Kurohane, Yasuo Niwa, Hirokazu Kobayashi, et al. Plant-derived secretory component gives protease-resistance to Shiga toxin 1-specific dimeric IgA. Plant Molecular Biology. 2021. 106. 3. 297-308
Nakanishi K, Matsuda M, Ida R, Hosokawa N, Kurohane K, Niwa Y, Kobayashi H, Imai Y. Lettuce-derived secretory IgA specifically neutralizes the Shiga toxin 1 activity. Planta. 2019. 250. 4. 1255-1264
Katsuhiro Nakanishi, Shota Morikane, Nao Hosokawa, Yuka Kajihara, Kohta Kurohane, Yasuo Niwa, Hirokazu Kobayashi, Yasuyuki Imai. Plant-derived secretory component forms secretory IgA with shiga toxin 1-specific dimeric IgA produced by mouse cells and whole plants. Plant Cell Rep. 2018
Katsuhiro Nakanishi, Shota Morikane, Shiori Ichikawa, Kohta Kurohane, Yasuo Niwa, Yoshihiro Akimoto, Sachie Matsubara, Hayato Kawakami, Hirokazu Kobayashi, Yasuyuki Imai. Protection of Human Colon Cells from Shiga Toxin by Plant-based Recombinant Secretory IgA. SCIENTIFIC REPORTS. 2017. 7. 45843

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MISC (19)：

茂木典子, 中西勝宏, 黒羽子孝太, 菊地祐希, 松田弥奈美, 森兼捷太, 丹羽康夫, 小林裕和, 今井康之. Digestive enzyme resistance of secretory IgA is created by plant-derived secretory component in vitro. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
高瀬太一, 大平裕也, 中西勝宏, 黒羽子孝太, 今井康之. Effect of oral administration of leukotriene C4 on sensitivity to Shiga toxin 1 in mice. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
井田涼太, 松田弥奈美, 中西勝宏, 黒羽子孝太, 丹羽康夫, 小林裕和, 今井康之. レタスで作製した志賀毒素特異的IgA植物抗体の抗原結合性と毒素中和活性の評価. 日本薬学会年会要旨集(CD-ROM). 2019. 139th
中西勝宏, 黒羽子孝太, 今井康之. 1型線毛を標的としたIgA型イムノアドヘシンによる細菌の宿主細胞への接着阻害効果の解析. 日本薬学会年会要旨集(CD-ROM). 2019. 139th
大平裕也, 梶原優佳, 森兼捷太, 中西勝宏, 黒羽子孝太, 丹羽康夫, 小林裕和, 今井康之. 植物で作製した分泌片への小胞体保留シグナル配列の付加:植物型糖鎖の削減. 日本薬学会年会要旨集(CD-ROM). 2019. 139th

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Education (3)：

2011 - 2014 University of Shizuoka Graduate School of Pharmaceutical Sciences
2009 - 2011 University of Shizuoka Graduate School of Pharmaceutical Sciences
2005 - 2009 University of Shizuoka School of Pharmaceutical Sciences Division of Medicinal Science

Professional career (1)：

Work history (3)：

Association Membership(s) (3)：

JAPANESE SOCIETY FOR PLANT CELL AND MOLECULAR BIOLOGY , THE JAPANESE SOCIETY FOR IMMUNOLOGY , THE PHARMACEUTICAL SOCIETY OF JAPAN

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