Rchr
J-GLOBAL ID：201801012937372112
Update date: Aug. 20, 2024
Wakabayashi Tomoko
ワカバヤシ トモコ | Wakabayashi Tomoko
Affiliation and department：
Other affiliations (1)：
Research field (2)：
Neuroscience - general
, Neuropathology
Research theme for competitive and other funds (11)：
- 2024 - 2027 ドコサヘキサエン酸によるパーキンソン病の発症・進展予防効果の検討
- 2023 - 2025 認知症の病態を末梢から制御する老化・生活習慣関連因子の探索
- 2020 - 2023 神経変性疾患におけるストレス依存的な凝集タンパク質の生成・放出機構
- 2020 - 2023 軸索発達促進因子25型コラーゲンの分子基盤と先天性脳神経支配異常症の病態機序
- 2017 - 2020 Elucidation of the molecular mechanisms of Abeta economy in the brain of Alzheimer's disease
- 2017 - 2020 Molecular bases of collagen XXV functions in neurological diseases and healthy aging.
- 2014 - 2017 The elucidation of functions of CLAC-P/collagen XXV in neuromuscular development and synapse formation
- 2010 - 2015 Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapies
- 2012 - 2014 Physiological functions of CLAC-P/Col XXV in axon elongation and synapse formation
- 2009 - 2010 Analysis of the gamma-secretase interactome and regulation mechanisms of the enzymatic activity.
- 2003 - 2004 アルツハイマー老人斑構成因子CLAC-P/XXV型コラーゲンの生理機能の解析
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Papers (23)：
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Itaru Nishida, Kaoru Yamada, Asami Sakamoto, Tomoko Wakabayashi, Takeshi Iwatsubo. Chronic Neuronal Hyperexcitation Exacerbates Tau Propagation in a Mouse Model of Tauopathy. International Journal of Molecular Sciences. 2024. 25. 16. 9004-9004
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Toshiharu Sano, Toshitaka Ochiai, Takeru Nagayama, Ayaka Nakamura, Naoto Kubota, Takashi Kadowaki, Tomoko Wakabayashi, Takeshi Iwatsubo. Genetic Reduction of Insulin Signaling Mitigates Amyloid-β Deposition by Promoting Expression of Extracellular Matrix Proteins in the Brain. The Journal of neuroscience. 2023. 43. 43. 7226-7241
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Yuya Kishino, Koji Matsukawa, Taisei Matsumoto, Ryota Miyazaki, Tomoko Wakabayashi, Takashi Nonaka, Fuyuki Kametani, Masato Hasegawa, Tadafumi Hashimoto, Takeshi Iwatsubo. Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration. Journal of Biological Chemistry. 2022. 298. 8. 102191-102191
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Toshitaka Ochiai, Toshiharu Sano, Takeru Nagayama, Naoto Kubota, Takashi Kadowaki, Tomoko Wakabayashi, Takeshi Iwatsubo. Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease. Neurobiology of Disease. 2021. 105510-105510
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T. Ochiai, T. Nagayama, K. Matsui, K. Amano, T. Sano, T. Wakabayashi, T. Iwatsubo. Tauroursodeoxycholic Acid Attenuates Diet-Induced and Age-Related Peripheral Endoplasmic Reticulum Stress and Cerebral Amyloid Pathology in a Mouse Model of Alzheimer’s Disease. The Journal of Prevention of Alzheimer's Disease. 2021. 1-12
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MISC (43)：
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若林朋子. Relationship of obesity, diabetes, and impaired insulin signaling to the development of Alzheimer’s disease pathology. Dementia Japan. 2023. 37. 2
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岸野祐也, 岸野祐也, 岸野祐也, 松川浩二, 松本大成, 宮崎良太, 宮崎良太, 若林朋子, 若林朋子, 野中隆, et al. casein kinase 1δ/εがFUSの神経毒性に与える影響に関する検討. Dementia Japan. 2022. 36. 4
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長山建, 佐野俊春, 佐野俊春, 落合敏平, 落合敏平, 若林朋子, 若林朋子, 岩坪威. 脳インスリンシグナルによるアルツハイマー病態制御機構の解明. Dementia Japan. 2022. 36. 4
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若林朋子. Insulin signaling and the pathology of Alzheimer’s disease. Neuropathology (Web). 2022. 42. Supplement
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落合敏平, 落合敏平, 長山建, 松井健太郎, 天野康一, 佐野俊春, 若林朋子, 若林朋子, 岩坪威. TUDCAによる末梢の小胞体ストレスの軽減が脳のアミロイド病態を改善する. Dementia Japan. 2021. 35. 4
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Education (2)：
- 1999 - 2004 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Technology
- 1995 - 1999 The University of Tokyo Faculty of Pharmaceutical Sciences Department of Pharmacy
Committee career (1)：
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