Kawai Kentaro

カワイケンタロウ | Kawai Kentaro

Affiliation and department：
Job title： Professor

Research field (2)： Computational science , Pharmaceuticals - chemistry and drug development

Research keywords (4)： Organic Chemistry , Computer Chemistry , Cheminformatics , Medicinal Chemistry

Research theme for competitive and other funds (4)：

2023 - 2026 アンテドラッグとして作用する、安全で新規な薬物動態学的増強因子の創出
2022 - 2025 多剤耐性菌のMATE型多剤排出ポンプを選択的に阻害するリード化合物の創出
2019 - 2023 Development of small molecule fluorescent compounds and elaboration of fluorescent probe for periodontal bacteria
2020 - 2021 男性不妊薬を指向した精子の受精能獲得を惹起する薬剤の創生

Papers (57)：

Kazuyuki Sato, Kazuki Nakano, Takahiro Ueda, Yukine Kitamura, Yuna Tanaka, Yukiko Karuo, Atsushi Tarui, Kentaro Kawai, Masaaki Omote. Construction of new quaternary carbon center of fluorinated isoxazolines at C5 position via C-F bond cleavage. Journal of Fluorine Chemistry. 2024. 279
Kentaro Kawai, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Makoto Kataoka, Masaaki Omote. Development of Drug Discovery Platforms Using Artificial Intelligence and Cheminformatics. Chemical and Pharmaceutical Bulletin. 2024. 72. 9. 794-799
Kentaro Kawai. Advancements and Challenges of Artificial Intelligence in Drug Discovery and Synthetic Organic Chemistry. Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2024. 82. 8. 780-790
Atsushi Tarui, Hiroshi Shimomura, Yohei Yasuno, Yukiko Karuo, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote. Decarboxylative Aldol Reaction of α,α-Difluoro-β-keto Esters: Easy Access to Difluoroenolate. ACS Omega. 2024. 9. 24. 26275-26284
Kataoka, M., Takenaka, S., Fujii, S., Masada, T., Minami, K., Takagi, T., Omote, M., Kawai, K., Yamashita, S. In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition. Drug Metabolism and Pharmacokinetics. 2024. 56

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MISC (4)：

Yusuke Endo, Kentaro Kawai, Takeshi Asano, Seiji Amano, Keisuke Sawada, Keiji Ogura, Noriko Ueo, Nobuaki Takahashi, Yo Sonoda, Mika Nagai, et al. Discovery of thienopyrimidinones as a new series of potent phosphodiesterase 7 inhibitors. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2015. 249
Kawai Kentaro. An approach to in-silico drug design utilizing chemoinformatics. Proceedings of the Symposium on Chemoinformatics. 2015. 2015. 8-9
Kentaro Kawai, Naoya Nagata. Comprehensive analysis of zinc binding groups using the protein data bank. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2011. 241
M Shimano, N Kamei, T Tanaka, K Kawai, K Miyawaki, A Okuyama, Y Murakami, Y Arakawa, M Haino, T Harada. Reverse hydroxamate-based selective TACE inhibitors. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2004. 228. U958-U958

Books (2)：

Education (2)：

1999 - 2001 Hokkaido University Graduate School of Science Division of Chemistry
1995 - 1999 Hokkaido University School of Science Chemistry

Work history (3)：

2024/04 - 現在 Setsunan University Faculty of Pharmaceutical Sciences Professor
2018/04 - 2024/03 Setsunan University Department of Pharmaceutical Sciences Associate Professor
2001/04 - 2018/03 Kaken Pharmaceutical

Committee career (7)：

2024/04 - 現在 Pharmaceutical Society of Japan Division of SAR
2023/02 - 現在 The Pharmaceutical Society of Japan Board member
2019/04 - 現在 The Pharmaceutical Society of Japan Division of Structure-Activity Studies (DSAS)
2018/04 - 現在文部科学省科学技術・学術政策研究所専門調査員
2020/04 - 2023/03 The Pharmaceutical Society of Japan Chem. Pharm. Bull., Editor

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Association Membership(s) (3)：

American Chemical Society , CHEM-BIO INFORMATICS SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN

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