Ochi Hiroki

オチヒロキ | Ochi Hiroki

Affiliation and department：
Job title： Researcher

Research field (1)： Physiology

Research keywords (5)：感覚神経 , 臓器連関 , 骨格筋 , 軟骨代謝 , 骨代謝

Research theme for competitive and other funds (14)：

2022 - 2025 神経・血管の視点から解き明かす筋骨格系の恒常性維持機構と筋骨格系疾患の新たな病態
2021 - 2024 感覚神経-骨組織連関に着目した廃用性骨萎縮の病態解明
2021 - 2023 グリア細胞シングルセル解析に基づくリハビリテーション効果促進薬開発の分子基盤構築
2019 - 2022 Development of optical bone clearing technique and elucidation of pathophysiology of bone metabolic disorders focusing on neural-vascular network
2018 - 2021 感覚神経-骨細胞ネットワークから解き明かす骨のメカニカルストレス応答機構

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Papers (60)：

Makoto Arai, Hiroki Ochi, Satoko Sunamura, Nobuaki Ito, Masaomi Nangaku, Shu Takeda, Shingo Sato. A Novel Long Noncoding RNA in Osteocytes Regulates Bone Formation through the Wnt/β-Catenin Signaling Pathway. International journal of molecular sciences. 2023. 24. 17
Tomoyuki Tanaka, Yuri Miyakoshi, Yutaka Kobayashi, Sun Xiaolong, Yu Daiyang, Hiroki Ochi, Shingo Sato, Tsuyoshi Kato, Toshitaka Yoshii, Atsushi Okawa, et al. Regulation of Osteoblast to Osteocyte Differentiation by Cyclin-Dependent Kinase-1. Advanced biology. 2023. e2300136
Shuhei Murase, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Ayumu Konno, Hirokazu Hirai, Taku Saito, Sakae Tanaka, Keisuke Shinohara, et al. Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans. Nature biomedical engineering. 2023
Alkebaier Aobulikasimu, Tao Liu, Jinying Piao, Shingo Sato, Hiroki Ochi, Atsushi Okawa, Kunikazu Tsuji, Yoshinori Asou. SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption. Scientific reports. 2023. 13. 1. 7991-7991
Kurando Utagawa, Takaei Shin, Hironori Yamada, Hiroki Ochi, Satoko Sunamura, Aiko Unno, Chihiro Akazawa, Masatsugu Ema, Shu Takeda, Atsushi Okawa, et al. Three-dimensional visualization of neural networks inside bone by Osteo-DISCO protocol and alteration of bone remodeling by surgical nerve ablation. Scientific reports. 2023. 13. 1. 4674-4674

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MISC (92)：

橋本恭子, 越智広樹, 砂村聡子, 小坂展慶, 大川淳, 落谷孝広, 二口充, 竹田秀, 佐藤信吾. がん細胞由来分泌型マイクロRNAによる骨転移微小環境制御機構の解明. 日本骨代謝学会学術集会プログラム抄録集. 2018. 36回. 145-145
室井謙宏, 越智広樹, 神野信夫, 鈴木周二, 余戸拓也, 原田恭治, 原康. 骨形成不全症が疑われた犬の1例. 日本獣医麻酔外科学雑誌. 2018. 49. Suppl.1. 289-289
Guangwen Jin, Jinying Piao, Zulipiya Aibibula, Alkebaier Aobulikasimu, Daisuke Koga, Hiroki Ochi, Kunikazu Tsuji, Toshio Miyata, Atsushi Okawa, Yoshinori Asou. PAI-1 inhibitor treatment attenuate bone loss through stimulating bone formation in a mouse model of postmenopausal osteoporosis. JOURNAL OF BONE AND MINERAL RESEARCH. 2017. 32. S385-S386
Kyoko Hashimoto, Satoko Sunamura, Hiroki Ochi, Toru Fukuda, Atsushi Okawa, Mitsuru Futakuchi, Shu Takeda, Shingo Sato. Cancer cell-derived microRNA induces osteoblastic phenotype in bone metastasis microenvironment. JOURNAL OF BONE AND MINERAL RESEARCH. 2017. 32. S64-S65
Hiroki Ochi, Paul Baldock, Shu Takeda. Central Neuronal Control of Bone Remodeling. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 9th Edition. 2017

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Books (2)：

Lectures and oral presentations (26)：

骨形成不全症が疑われた犬の1例
(日本獣医麻酔外科学会 2018)
Cancer-secreted Hsa-miR-940 Induces Osteoblastic Phenotype in the Bone Metastatic Microenvironment
(Orthopaedic Research Society Annual Meeting 2018 2018)
がん細胞由来分泌型マイクロRNAによる骨転移微小環境制御機構
(第1回日本サルコーマ治療研究学会(JSTAR)学術集会 2018)
がん細胞由来分泌型マイクロRNAが造骨型骨転移を惹起する
(第3回日本骨免疫学会ウインターセミナー 2018)
Cancer-secreted hsa-miR-940 induces osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A
(ERATO/AMED-CREST/PRESTO Joint International Symposium 2017)

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Work history (1)：

2014/04 - 2019/03 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Systemic Organ Regulation Physiology and Cell Biology Assistant Professor

Awards (1)：

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