Rchr
J-GLOBAL ID：201801013254844074   Update date: Apr. 08, 2024

Fujihara Yoshitaka

フジハラ ヨシタカ | Fujihara Yoshitaka
Affiliation and department：
National Cerebral and Cardiovascular Center, Research Institute Department of Advanced Medical Technologies

About National Cerebral and Cardiovascular Center, Research Institute Department of Advanced Medical Technologies


Job title： Director
Other affiliations (2)：
Research field  (3)： Developmental biology ,  Laboratory animal science ,  Animals: biochemistry, physiology, behavioral science
Research theme for competitive and other funds  (14)：
  • 2024 - 2029 遺伝子組換え動物を用いた進化生殖遺伝子群の包括的解明
  • 2021 - 2024 Elucidating the universality and specificity of reproductive mechanisms between species using genetically modified animals
  • 2021 - 2024 Novel roles of seminolipid in the mouse testis
  • 2020 - 2024 Elucidating the molecular mechanisms of fertilization common to vertebrate animal models
  • 2021 - 2023 Development of new diagnostic markers and reversible fertility inhibitors for mammalian spermatozoa
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Papers (109)：
  • Yoshitaka Fujihara, Haruhiko Miyata, Ferheen Abbasi, Tamara Larasati, Kaori Nozawa, Zhifeng Yu, Masahito Ikawa, Martin M Matzuk. Tex46 knockout male mice are sterile secondary to sperm head malformations and failure to penetrate through the zona pellucida. PNAS Nexus. 2024
  • Akane Morohoshi, Haruhiko Miyata, Keizo Tokuhiro, Rie Iida-Norita, Taichi Noda, Yoshitaka Fujihara, Masahito Ikawa. Testis-enriched ferlin, FER1L5, is required for Ca 2+ -activated acrosome reaction and male fertility. Science Advances. 2023. 9. 4
  • Nobuyuki Sakurai, Yoshitaka Fujihara, Kiyonori Kobayashi, Masahito Ikawa. CRISPR/Cas9-mediated disruption of lipocalins, Ly6g5b, and Ly6g5c causes male subfertility in mice. Andrology. 2022
  • Yoshitaka Fujihara, Kiyonori Kobayashi, Ferheen Abbasi, Tsutomu Endo, Zhifeng Yu, Masahito Ikawa, Martin M. Matzuk. PDCL2 is essential for sperm acrosome formation and male fertility in mice. Andrology. 2022
  • Qiuji Ye, Belabed H, Wang Y, Yu Z, Palaniappan M, Li JY, Kalovidouris SA, MacKenzie KR, Mingxing Teng, Young DW, et al. Advancing ASMS with LC-MS/MS for the discovery of novel PDCL2 ligands from DNA-encoded chemical library selections. Andrology. 2022
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MISC (14)：
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Books (1)：
  • ゲノム編集成功の秘訣Q&A : 論文だけではわからない : TALEN、CRISPR/Cas9の極意
    羊土社 2015 ISBN:9784758101936
Education (3)：
  • - 2010 Osaka University Graduate School of Medicine PhD/Medicine
  • - 2006 Osaka University Graduate School of Medicine MSc/Medical Science
  • - 2004 Kobe University Faculty of Agriculture BSc/Agriculture
Professional career (1)：
  • PhD. (Osaka University)
Work history (16)：
  • 2024/02 - 現在 National Cerebral and Cardiovascular Center Open Innovation Center Concurrent Director
  • 2023/04 - 現在 The University of Tokyo The Institute of Medical Science Adjunct Researcher
  • 2023/04 - 現在 Osaka University Research Institute for Microbial Diseases Guest Professor
  • 2022/12 - 現在 National Cerebral and Cardiovascular Center Medical Genome Center Concurrent Director
  • 2022/11 - 現在 Baylor College of Medicine Department of Pathology & Immunology Adjunct Professor
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Awards (13)：
  • 2022/11 - Sugiyama Memorial Foundation 4th SMF Paper Award First Prize
  • 2018/07 - Society for the Study of Reproduction Best International Abstract Award
  • 2017/05 - Japanese Association for Laboratory Animal Science Young Investigator Award
  • 2015/06 - Japanese Society of Developmental Biologists DGD Wiley Blackwell Prize 2015
  • 2014/01 - 大阪大学微生物病研究所 研究業績発表会 優秀学術賞
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Association Membership(s) (6)：
Society for Reproduction and Development ,  Japan Society of Andrology ,  Society for the Study of Reproduction ,  The Molecular Biology Society of Japan ,  Japanese Association for Laboratory Animal Science ,  Kansai Laboratory Animal Research Association
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