- 2022 - 2025 HBp17/FGFBPノックアウトによる扁平上皮細胞の分化誘導メカニズムの解明
- 2021 - 2024 E-カドヘリンプロセシングを介した口腔癌細胞増殖機構の解明と治療応用への基盤研究
- 2019 - 2022 HBp17/FGFBPを制御するエクソソーム由来miRNAによる口腔癌治療の開発
- 2019 - 2022 細胞接着分子を標的とした選択的オートファジー誘導による口腔癌転移阻止療法の開発
- 2018 - 2021 Establishment study of liquid biopsy by isolation of circulating oral cancer cells in blood and analysis of their cell characteristics
- 2017 - 2020 Development of gene therapy for oral cancer using Sendai virus vector with alpha2-antiplasmin gene
- 2016 - 2019 Developmental study of oral cancer treatment using vitamin D derivative (ED-71) which is used for an osteoporosis treatment
- 2015 - 2018 Functional Cytokine network in the Oral Cancer Stem Cell Niche and its applicastion for diagnosis and treatment
- 2014 - 2017 Development of gene therapy for oral cancer with direct injection of Naked DNA of alpha2-antiplasmin gene
- 2013 - 2016 Development of molecular target diagnosis and therapy targeted HBp17/FGFBP protein
- 2012 - 2015 Elucidation of cytokine network in oral squamous cell carcinoma stem cell niche, and its application to diagnosis/treatment
- 2012 - 2015 Study on the prevention therapy for the invasion and metastasis of oral cancer by the suppression of E-cadherin processing
- 2012 - 2015 Development research of new therapies targeting VEGF receptor that was expressed in oral cancer cells, and its signaling
- 2011 - 2013 Purification, structure characterization of bioactive substances from marine organisms and application them to the novel targeting oral cancer drugs
- 2011 - 2013 Study of the delivery system of nucleic acid medicines targeting cell adhesion molecules controlling the metastasis of oral cancer
- 2009 - 2011 Isolation of molecules synthesized by stromal cells, which regulate tumor invasion and metastasis : application in diagnosis and therapy
- 2009 - 2011 Identification of Cancer Stem Cell and its niche system in Oral Cancer
- 2008 - 2009 E-カドヘリンプロセス分子のNaked DNAを用いた口腔癌の遺伝子治療法の開発
- 2007 - 2008 口腔癌における癌幹細胞の分離・同定と同細胞を標的とした新しい診断・治療法の開発
- 2005 - 2006 Search of Molecular Targets for Oral Cancer by Proteome Analysis and Its Application for Order-Made Therapy
- 2005 - 2006 Experimental study on the inhibition of invasion and metastasis of oral cancer by the suppression of processing of E-cadherin
- 2005 - 2006 Development of molecular target therapy to VEGF and VEGFR against oral cancer with RNAi methods
- 2003 - 2004 Search for Molecular Targets by Proteome Analysis and Its Use to Taylored-Made Therapy against Oral Cancer
- 2002 - 2003 Gene therapy targeting cell adhesion molecule that regulate metastasis of oral cancer
- 2002 - 2003 Suppression of angiogenesis in oral cancer by cyclooxygenase inhibitors
- 2002 - 2002 FGF,FGF結合蛋白およびFGF受容体を標的とした扁平上皮癌の分子標的治療
- 2001 - 2001 FGF、FGF結合蛋白およびFGF受容体を標的とした扁平上皮癌の分子標的治療
- 2000 - 2001 Participation of Stromal component in Cancer Progression
- 2000 - 2001 Apoptosis induces of a multi-drug resistant oral cancer cells by Tax01, Alkaroid derived ICHI
- 1999 - 2000 Gene Diagnosis/Therapy of Oral Cancer Targetted for Autocrine Growth Factor and Angiogenic Factor Genes
- 1999 - 2000 Gene Diagnosis and Therapy of Salivary Gland Tumors Targetted for FGFR genes
- 1999 - 2000 セリンプロテアーゼ阻害剤を用いた口腔癌転移に対する薬物療法
- 1999 - 1999 FGF結合蛋白(FGFBP/HBp17)を標的とした扁平上皮癌の分子標的治療
- 1994 - 1994 ヒト線維芽細胞由来がん細胞遊走促進因子の同定とそれに対する抗体作製
- 1993 - 1993 ヒト線維芽細胞からの癌浸潤促進因子の分離
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