Research theme for competitive and other funds (6)：
2020 - 2023 The study of the mood system by single cellular analysis of bipolar model animal
2017 - 2022 Role of paraventricular thalamic nucleus in bipolar disorder
2020 - 2022 Single Cellular Pathophysiology of Bipolar Model
2018 - 2021 Significance of MAOB in paraventricular nucleus-specific mitochondrial defects that relevant to a cause of mood disorders
平面内細胞極性及び神経突起形成に関与する遺伝子のマウスにおける役割の解析
Study on the gene participating planar cell polarity and neurite formation in mouce
Show all
Papers (22)：
Tadafumi Kato, Mie Kubota-Sakashita, Yasuyuki Shima, Masaki Nishioka. The emerging role of the paraventricular thalamic nucleus in bipolar disorder: Lessons from mitochondrial dysfunction. Psychiatry and Clinical Neurosciences. 2026
Haruko Nakagawa, Yasuyuki Shima, Yohei Sasagawa, Itoshi Nikaido. MitoDelta: identifying mitochondrial DNA deletions at cell-type resolution from single-cell RNA sequencing data. BMC Genomics. 2025. 26. 1
Yasuyuki Shima, Shota Sasagawa, Nakao Ota, Rieko Oyama, Minoru Tanaka, Mie Kubota-Sakashita, Hirochika Kawakami, Mika Kobayashi, Naoko Takubo, Atsuko Nakanishi Ozeki, et al. Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms. Science Translational Medicine. 2023. 15. 700
David Levitan, Chenghao Liu, Tracy Yang, Yasuyuki Shima, Jian-You Lin, Joseph Wachutka, Yasmin Marrero, Ramin Ali Marandi Ghoddousi, Eduardo da Veiga Beltrame, Troy A Richter, et al. Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory. eLife. 2020. 9
