Kobayashi Takashi

2019 - 2022 Molecular analysis of the drug resistance mediated by exosomes in biliary tract cancer

2018 - 2021 The new classification of colorectal cancer focusing on differences of molecular mechanisms in TGF-b signal pathway

2018 - 2021 The role of lipid mediators for lymphvascular invasion in hepatocellular carcinoma and its clinical significance

2017 - 2020 Creation of next-generation cell therapy for diabetes with focus on nesidioblastic change

2017 - 2020 Elucidation of clinical significance and chemotherapy resistance mechanism of NAD(P)H:quinone oxidoreductase 1 (NQO1) expression for colorectal liver metastasis

2017 - 2020 Elucidation and clinical significance of tumor microenvironmental mechanism of pancreatic cancer through tumor-associated macrophages

2017 - 2020 Establishment of a new methodology to distinguish between benign and malignant lesions in bile duct biopsy specimens based on an early repair mechanism for DNA double-strand breaks

2016 - 2019 The mechanism of exosome-mediated drug resistance in hepatoma cells

2016 - 2019 Elucidation of molecular mechanism through autophagy in carcinogenesis of hepatocellular carcinoma

2016 - 2019 Elucidation of the signal expression mechanism in the mTOR cell and development of the rapamycin treatment in the hepatoblastoma

2016 - 2019 Elucidation of a novel cell signaling mechanism by lipid mediators and bile acids in biliary diseases

2015 - 2018 Elucidation of molecular mechanism of lipid mediator involved in metastatic ability of biliary tract cancer / pancreatic cancer and clinical application

2015 - 2018 Serum carnitine kinetics by administration of fat emulsion at the perioperative period and effect of intravenous administration of L-carnitine

2015 - 2018 Clinical Significance and elucidation of molecular regulation mechanism of lipid mediators in invasion and metastatic ability of gastric cancer

2015 - 2018 The role of MED12 expression in molecular mechanism of drug resistance of colorectal cancer

2015 - 2018 The molecular mechanism of a lipid mediator involved in metabolic dynamics of breast cancer

2014 - 2017 Elucidation of the mechanism of drug resistance in colorectal cancer by p62-Keap 1-Nrf2 pathway

2014 - 2017 Biological evaluation and significance of tumor budding using fluorescence immunohistochemistry in pT1b colorectal cancer

2014 - 2017 Prediction of Chemotherapy Response to Pancreatic Cancer Using Photodynamic diagnosis

2014 - 2017 Assessment of proliferation and apoptotic rate of tumor budding cells in pancreatic ductal adenocarcinoma.

2013 - 2016 Pancreatectomy and islet autotransplantation for chronic pancreatitis

2013 - 2016 慢性膵炎に対する自家膵島移植を併用した膵切除に関する研究

2009 - 2009 慢性膵炎に対する自家膵島移植を併用した膵切除に関する研究