Rchr
J-GLOBAL ID：201801014023765062   Update date: Jul. 17, 2024

Mineaki Seki

セキ ミネアキ | Mineaki Seki
Affiliation and department：
Niigata University of Pharmacy and Applied Life Sciences

About Niigata University of Pharmacy and Applied Life Sciences


Job title： Professor
Research field  (4)： Virology ,  Pharmaceuticals - health and biochemistry ,  Environmental effects of radiation ,  Molecular biology
Research keywords  (6)： ゲノム安定性 ,  DNA修復 ,  ウイルス学 ,  small RNA ,  マクロファージ ,  自然免疫
Research theme for competitive and other funds  (7)：
  • 2019 - ヒト特異的肥満関連分子の発現・機能解析系とRNA創薬スクリーニング系の構築
  • 2014 - 2016 DNA修復における鉄の役割と遺伝病への関与:新規複合体CIAXの機能関与
  • 2013 - 2014 DNA修復の新展開:鉄代謝異常と環境応答、ゲノム安定性
  • 2010 - 2012 Novel functions of DNA repair factors: The roles of new XPD complex in the DNA damage responses
  • 2009 - 2009 染色体分配におけるゲノム安定性
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Papers (28)：
  • Mineaki Seki, Akihiko Komuro, Masayuki Takahashi, Masayuki Nashimoto. Transcription from the proximal promoter of ELAC1, a gene for tRNA repair, is upregulated by interferons. Biochemical and Biophysical Research Communications. 2021. 585. 162-168
  • Masayuki Takahashi, Mineaki Seki, Masayuki Nashimoto, Tomohiro Kabuta. Perturbing the Normal Level of SIDT1 Suppresses the Naked ASO Effect. Journal of Nucleic Acids. 2021. 2021(Article ID 2458470. https://doi.org/10.1155/2021/2458470
  • Masayuki Takahashi, Mineaki Seki, Masayuki Nashimoto. A naked antisense oligonucleotide with phosphorothioate linkages is taken up intracellularly more efficiently but functions less effectively. Biochemical and Biophysical Research Communications. 2021. 573. 140-144
  • Tadasuke Nozaki, Masayuki Takahashi, Tatsuya Ishikawa, Arisa Haino, Mineaki Seki, Hidetomo Kikuchi, Bo Yuan, Masayuki Nashimoto. The heptamer sgRNA targeting the human OCT4 mRNA can upregulate the OCT4 expression. Biochemistry and Biophysics Reports. 2021. 26. 100918-100918
  • Kato Y, Takahashi M, Seki M, Nashimoto M, Shimizu-Ibuka A. RNA-hydrolyzing activity of metallo-β-lactamase IMP-1. PLOS ONE. 2020. 15. 10
ｍore...
MISC (2)：
  • The discovery of DNA polymerase theta (POLQ) and its essential roles in alternative end-joining pathway. 2017. 51. 2. 35-47
  • M Seki, PJ Gearhart, RD Wood. DNA polymerases and somatic hypermutation of immunoglobulin genes. EMBO REPORTS. 2005. 6. 12. 1143-1148
Lectures and oral presentations  (7)：
  • 骨髄腫微小環境sgRNA薬による新たな多発性骨髄腫治療法の開発
    (第22回バイオ治療法研究会学術集会 2018)
  • MMS19 functions is a cytosolic Fe-S assembly factor required for t genomic integrity.
    (8th 3R Symposium 2012)
  • DNA Polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct.
    (Environmental Mutagen Society Meeting 2007)
  • Mechanisms of translesion DNA Synthesis by human POLQ
    (10th Annual DNA Replication and Repair Symposium 2006)
  • POLQ dependent AP site bypass reaction and DNA dependent ATPase activity: Implication from biochemical studies
    (5th 3R Symposium 2005)
ｍore...
Works (2)：
  • Enzyme Patches Genetic Holes
    2004 -
  • A look at duct tape
    2004 -
Education (3)：
  • 1994 - 1998 The University of Tokyo Graduate School, Division of Agricultural Science
  • 1992 - 1994 The University of Tokyo Graduate School, Division of Agricultural Science
  • 1988 - 1992 The University of Tokyo Faculty of Agriculture
Professional career (1)：
  • 博士(農学) (東京大学大学院)
Work history (12)：
  • 2014/04 - 2015/01 Assistant Professor
  • 2013/04 - 2014/03 名古屋大学 医学部
  • 2013/04 - 2014/03 Nagoya University School of Medicine
  • 2009/04 - 2014/03 Assistant Professor
  • 2008/06 - 2009/03 Researcher
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Association Membership(s) (4)：
日本分子生物学会 ,  日本環境変異原学会 ,  日本放射線影響学会 ,  日本生化学会
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